DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcn3

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_001923503.1	Gene:	clcn3 / 559340	ZFINID:	ZDB-GENE-030131-1699	Length:	874	Species:	Danio rerio

Alignment Length:	881	Identity:	246/881 - (27%)
Similarity:	391/881 - (44%)	Gaps:	209/881 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSALARRATLSGNNHLLD----DSQPLLMGNNSVPPDIPI-NGSAGSPNRNINS------SEPIF 100
            |||.:....|.|...::|    :...||.|:.|...:..: ||..|....:.::      .|||
Zfish    20 TSASSDEELLDGAGVIMDFHTTEDDNLLDGDASPGSNYAMSNGGGGGGGASSSTHLLDLLEEPI- 83

  Fly   101 HLRSRTAAASTPNYESLDY--EVCENTLFQDEQR------KRLTERFSLRKDII----RWIIFIQ 153
                 ....:..::.::|:  |.|     :|.:|      |:....:...|.:.    .|::...
Zfish    84 -----PGVGTYDDFHTIDWVREKC-----KDRERHRKINSKKKESAWEFTKSLYDAWSGWLVVTL 138

  Fly   154 IGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLS----------------DASDRDLLIPY 202
            .|:.:..:|..|||..:.:         |.:||.|.||                ..::||....:
Zfish   139 TGLASGALAGGIDIAADWM---------NDLKEGVCLSAMWFNHEQCCWGSNKTTFAERDKCPQW 194

  Fly   203 LYW------------------LLFSIVPVAF---GAAMVTYIEPITAGSGIPQVKSYLNGVKIPR 246
            ..|                  .:|:...::|   ..::|....|...|||||::|:.|:|..|..
Zfish   195 KTWAELILGQEQGPGSYIMNYFMFTFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRG 259

  Fly   247 IVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEK 311
            .:...||.:|.|.::.:|..||:.|||||::|.....      |...::|    ..|..:::.:|
Zfish   260 YLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCC------GNIFSYL----FPKYSKNEAKK 314

  Fly   312 RDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLND 376
            |:.:....|||||.||||||||:||||||.:.::....:||:..|::::.|.|       ..:|.
Zfish   315 REVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVL-------RSINP 372

  Fly   377 F--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRK--RFIPWKIGK 437
            |  :...||.: ::.||  :..|||..|::|||.|||.||.:...|....:.||  ||     ||
Zfish   373 FGNSRLVLFYV-EYHTP--WYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTRF-----GK 429

  Fly   438 --VLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAAL 489
              |||.:.||.:...:|.           |:.....||.||.:.      || |:
Zfish   430 YPVLEVITVAAITAIVAFPNPYTRQNTSELIKELFTDCGPLESS------QL-CQ---------- 477

  Fly   490 WFQTPEATVRSLFH----DP----------PGSHKIL-TLALFTVVYYVLSCATFGLNVSLGVFI 539
                    .|||.:    ||          ||.:..: .|:|..|...:::..||||.|..|:||
Zfish   478 --------YRSLMNGSQADPTGPDTASAATPGVYSAMWQLSLALVFKIIMTIFTFGLKVPSGLFI 534

  Fly   540 PTALVGAAWGRLLAM----LTYY-----VFPQ-----AEFLHPGKYALIGAAANLGGVLRMTISL 590
            |:..:||..||::.:    |.||     ||.:     |:.:.||.||::||||.||||.|||:||
Zfish   535 PSMAIGAIAGRIVGIAVEQLAYYHHDWFVFREWCEVGADCITPGLYAMVGAAACLGGVTRMTVSL 599

  Fly   591 SVILMETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKARE 654
            .||:.|.|| ...:..||:.|::::|||||.| .||||:..|::|..|.|..:....:..| |||
Zfish   600 VVIVFELTG-GLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-ARE 662

  Fly   655 IL----SKPVICIKIRDSANY--IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVIL 713
            ::    |.|.:.:..:|....  :..::.:..:|||||:..     :...|:.|..||..:
Zfish   663 VMRPRRSDPPLAVLTQDDMTLAELQGIISETSYNGFPVIVS-----KESQRLVGFALRRDI---- 718

  Fly   714 LKSLYVEN---KRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHD 775
              ::.:||   |:..:...|...|....|..|: .|.|.|  |:...:|:      ||..|..|.
Zfish   719 --TIAIENARRKQEGIVLNSRVYFTQHAPTLPA-DSPRPL--KLRSILDM------SPFTVTDHT 772

  Fly   776 SVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .:..:..|||.||||..|| .|...:.||||:::.:
Zfish   773 PMEIVVDIFRKLGLRQCLV-THNGIVLGIITKKNIL 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	39/139 (28%)
		ClC_6_like	115..639	CDD:239657	183/619 (30%)
		Voltage_CLC	213..620	CDD:279048	150/455 (33%)
		CBS	653..811	CDD:223591	44/166 (27%)
clcn3	XP_001923503.1	ClC_3_like	140..648	CDD:239656	175/567 (31%)
clcn3	XP_001923503.1	CBS_pair_EriC_assoc_euk_bac	671..809	CDD:239964	41/158 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910