DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcn5b

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_685762.2	Gene:	clcn5b / 557584	ZFINID:	ZDB-GENE-110407-11	Length:	811	Species:	Danio rerio

Alignment Length:	860	Identity:	243/860 - (28%)
Similarity:	387/860 - (45%)	Gaps:	185/860 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SGNNHLLDDSQPLLMGNNSVPPDIPINGSAG--SPNRNINSSEPIFHLRSRTAAASTPNYESLDY 119
            |.::.|:|.|...:..|..||| :..:.|.|  ..:...|||..:..|...:...:..::.::|:
Zfish    15 SSDDELVDISDVTVDYNEDVPP-LDRDYSTGHCKADWRPNSSPKLMDLLDVSGIGTYEDFNTIDW 78

  Fly   120 EVCENTLFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIR 175
             |.|.:..:|..|: :|.:         ||:......|::.:.||:::..:|..|||....::..
Zfish    79 -VREKSRDRDRHRE-ITNKSKHSTLALLFSISDAFSGWLLMLLIGLMSGALAGGIDIAAHWMTDL 141

  Fly   176 K----------------YTFLYNSVKEN-------------VPLSDASDRDLLIPYLY------- 204
            |                :|:...:.||.             |.:|:::     :.|.|
Zfish   142 KEGVCQDGFWFNHEDCCWTYNGTTFKERDKCPQWKSWAELMVGVSEST-----VWYAYMASYFMY 201

  Fly   205 --W-LLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVG 266
              | |.||.:.|    .:|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..
Zfish   202 VCWALFFSFLAV----ILVRAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKTITLVLAVSS 262

  Fly   267 GLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331
            ||:.|||||::|.....|..:..     |...:|     |::.::|:.:....|.|||.||||||
Zfish   263 GLSLGKEGPLVHVACCCANILCH-----FFTKYR-----RNEAKRREVLSAASAVGVSVAFGAPI 317

  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKF 394
            ||:||||||.:.::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :
Zfish   318 GGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--W 372

  Fly   395 DYFELPIFMILGVTGGLLGA-------AWNSL--NTKINKFRKRFIPWKIGKVLEAVVVAMMGVT 450
            .:.||..|::||:.|||.||       ||..|  ||....:          .|||.::|.::...
Zfish   373 HFLELIPFILLGIFGGLWGAFFIRANIAWCRLRKNTSFGHY----------PVLEVIIVTLVTAF 427

  Fly   451 LA-----------CLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHD 504
            ||           .|:....|||..|.:....|          |.:|......:..||:.:...|
Zfish   428 LAFPNEFTRMSSSTLISELFNDCSLLDSSKLCN----------YTSVGGGRGGSVNATIANALAD 482

  Fly   505 PPGSHKILT----LALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY--- 558
            .|....:.|    |||..:...|::.||||:.|..|:|||:..|||..||||.:    |..|
Zfish   483 RPAGPGLYTAMWQLALALLFKMVMTVATFGMKVPSGLFIPSMAVGAIAGRLLGVFMEQLAVYHHD 547

  Fly   559 --VF-----PQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAK 616
              :|     |..:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|
Zfish   548 WAIFRGWCSPGTDCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSK 611

  Fly   617 WVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRD--SANYIYE 674
            ||.|.| .|.||:..|::|..|.|..:...::|.| |.:::    |.|.:.:..:.  |...:..
Zfish   612 WVADAFGRESIYEAHIRLNGYPFLEAKEEFRHKTL-ATDVMRPRRSDPPLSVLTQSGMSVEEVER 675

  Fly   675 MLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKR---FWLPETSIQTFRD 736
            ::....::|||||..:     :..|:.|.:||..||:.|      ||.|   ..:...|...|.:
Zfish   676 LIADTTYSGFPVVLSL-----TSQRLVGFVLRRDLIISL------ENARRHQEGVVSVSAVLFTE 729

  Fly   737 LYPRF-----PSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVIN 796
            ..|..     |::|              |...::.||..|..|..:..:..|||.||||..|| .
Zfish   730 CDPPASPNAPPAVK--------------LRSILDLSPFTVTVHTPMEIVVDIFRKLGLRQCLV-T 779

  Fly   797 HENRIAGIITRRDFI 811
            ...|:.||||::|.:
Zfish   780 QNGRLLGIITKKDIL 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	40/144 (28%)
		ClC_6_like	115..639	CDD:239657	182/612 (30%)
		Voltage_CLC	213..620	CDD:279048	147/446 (33%)
		CBS	653..811	CDD:223591	43/171 (25%)
clcn5b	XP_685762.2	ClC_3_like	121..635	CDD:239656	172/563 (31%)
		Voltage_CLC	207..615	CDD:279048	149/452 (33%)
		CBS_pair_EriC_assoc_euk_bac	658..796	CDD:239964	42/163 (26%)
		CBS	668..794	CDD:223591	41/151 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910