DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcn7

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001071005.1	Gene:	clcn7 / 553351	ZFINID:	ZDB-GENE-061103-196	Length:	795	Species:	Danio rerio

Alignment Length:	806	Identity:	364/806 - (45%)
Similarity:	517/806 - (64%)	Gaps:	51/806 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLLDDSQPLLMGNNSV 76
            |:...|..|::...|....::.:...|:..        :.|.:|:.....:..:...:    .|.
Zfish    14 GDDRGERTPLLNGAEDSKLNRQLSGGGIFH--------IGRLSTVDLEEEITPEEDII----RSR 66

  Fly    77 PPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSL 141
            |.:||.|             |.:..|:          ||||||:..||.||.:|:| |:::....
Zfish    67 PKEIPHN-------------EKLLSLK----------YESLDYDNSENQLFLEEER-RMSQMGFR 107

  Fly   142 RKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWL 206
            ..:|.||:|...||::|.||||.|||.:|.|:..||..:..::::...|...|     :..:.|.
Zfish   108 CLEITRWVICGLIGLLTGLIACLIDIAVENLAGLKYFAVKQNIEKFTELGGLS-----LSLILWA 167

  Fly   207 LFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGG 271
            :.:...|..||.:|.:.|||.|||||||:|.||||||:||:||:|||.||..|||.||.||||.|
Zfish   168 VLNSAFVMVGAIIVAFFEPIAAGSGIPQIKCYLNGVKVPRVVRLKTLVVKVFGVICSVAGGLAVG 232

  Fly   272 KEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLF 336
            |||||||:|||||||:|||:||:..|||::|:.||.|.||||||..|.|||||||||||:||:||
Zfish   233 KEGPMIHSGAVVAAGVSQGRSTSLKKDFKMFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLF 297

  Fly   337 SLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGL-NDFTFTGLFNLGKFDT-PLKFDYFEL 399
            ||||.||||||.|.||...||::|.||||..||.||.. .:.:..||.|.|:||: .::::.:|:
Zfish   298 SLEEGASFWNQLLTWRIFFASMVSSFTLNFFLSIYHQKPGELSSPGLINFGRFDSDSVQYNLYEI 362

  Fly   400 PIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVAMMGVTLACLMIYFINDCRP 464
            |:|:|:|..||:|||.:|.||..:..||.|:|.....:|:||::||.:..|::..||||..:|:|
Zfish   363 PLFIIMGALGGMLGALFNLLNYWLTIFRIRYIHRPCLQVMEAMLVAAVTATVSFAMIYFSTECQP 427

  Fly   465 LGNDPTNN-PVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCAT 528
            ||.|.|.. |:||||.|.||||:|..:|.|||.:||||||:|||::..:||.:||:.|::|:..|
Zfish   428 LGPDHTEEYPLQLFCADGEYNAMATAFFNTPERSVRSLFHNPPGTYNPMTLGVFTLAYFLLAVWT 492

  Fly   529 FGLNVSLGVFIPTALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSV 592
            :||.||.|||||:.|:|||||||.. :|::....::.:..|||||||||||.|||::|||:||:|
Zfish   493 YGLTVSAGVFIPSLLIGAAWGRLFGILLSFITTSKSIWADPGKYALIGAAAQLGGIVRMTLSLTV 557

  Fly   593 ILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILS 657
            ||:|.|| ..::.||:::.|::||.|||||.||:||..|::..||.|.||..|....|.|||::|
Zfish   558 ILVEATG-NVTYGFPIMLVLMTAKIVGDYFVEGLYDIHIKLQSVPFLHWEAPPTSHWLTAREVMS 621

  Fly   658 KPVICIKIRDSANYIYEMLK--KCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVE 720
            ..|.|....:....|.::|.  ..:|||||||..|. :.....::||::|||||||:|...::||
Zfish   622 SQVTCFNRIEKVGTIVDVLSNTSTNHNGFPVVTHVT-EIDEPSKLCGLVLRSQLIVLLKHKVFVE 685

  Fly   721 N--KRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQI 783
            .  .||...:..::.|||.|||||.|:|:....::....:||:.||||:|..|....|:||:|::
Zfish   686 RAFSRFSQRKLQLKDFRDAYPRFPPIQSIHVSQDERECMMDLTEFMNPTPYTVPQETSLPRVFKL 750

  Fly   784 FRALGLRHLLVINHENRIAGIITRRD 809
            |||||||||:|:::|||:.|::||:|
Zfish   751 FRALGLRHLVVVDNENRVVGLVTRKD 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	62/140 (44%)
		ClC_6_like	115..639	CDD:239657	275/527 (52%)
		Voltage_CLC	213..620	CDD:279048	231/410 (56%)
		CBS	653..811	CDD:223591	68/161 (42%)
clcn7	NP_001071005.1	ClC_6_like	82..604	CDD:239657	275/528 (52%)
		Voltage_CLC	172..584	CDD:279048	231/412 (56%)
		CBS_pair_EriC_assoc_euk_bac	625..780	CDD:239964	64/153 (42%)
		CBS	729..>780	CDD:223591	27/48 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586321
Domainoid	1	1.000	459	1.000	Domainoid score	I468
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56546
Inparanoid	1	1.050	666	1.000	Inparanoid score	I727
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		oto41205
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	1	1.100	-	-	LDO	PTHR11689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3132
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800