Protein Alignment ClC-b and ClC-c

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Alignment Length: 936
• Identity: 255/936 - (27%)
• Similarity: 415/936 - (44%)
• Gaps: 207/936 - (22%)

  Fly    13 ESSAEDDPII------LQKEAGPTSKAVQDFGLHQ--REEP--STSALARRATLSGNNHLLDDSQ 67
            |::||.:..|      ::|..|.|:.|..|..|..  |:.|  ..:.|....|.:|.    ||..
  Fly    11 EAAAEGNSYITAYQTVMKKSNGHTNGAGGDGDLDGTFRDHPLAQHTKLTTSLTAAGT----DDED 71

  Fly    68 PLLMGNNSVPPDIPINGSAGSPNRNI-------NSSEPIF----------HLRSRTAAASTPN-- 113
            .:.:...|.|.|:...|..|..:...       :.:|..|          |...||.....|.
  Fly    72 MIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHS 136

  Fly   114 ------------YESLD----------YEVCENTLFQ-DEQRKRLTERFSLRK------DIIR-- 147
                        |.|.|          ||......:| |..|.|:..|:.::|      |:|:
  Fly   137 AFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGS 201

  Fly   148 ------WIIFIQIGIITALIACTIDIIIEELSIRKY-----TFLYN------SVKENV------- 188
                  |:..:.:||....:|..:||....:|..|:     .|.:|      ..|::|
  Fly   202 IDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCS 266

  Fly   189 -----PLSDASDRD----LLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKI 244
                 |.....||:    .::.|::::|::::..:..|::|....|...|||||::|:.|:|..|
  Fly   267 TWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFII 331

  Fly   245 PRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF-RDD 308
            ...:...||.:|::|::.||..||..||||||:|..:.:....|           .:|..: |::
  Fly   332 RGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFS-----------HVFPKYGRNE 385

  Fly   309 HEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHG 373
            .:||:.:....|||||.||||||||:||||||.:.::....:||:...::|:.|.|. .|:.:..
  Fly   386 AKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLR-SLTPFGN 449

  Fly   374 LNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK- 437
            .:...|     ..:::.|  :.:|||..|:.||:.||::|..:...|....::||..   |:|:
  Fly   450 EHSVLF-----FVEYNKP--WIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS---KLGQY 504

  Fly   438 -VLEAVVVAMMGVTLAC------------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAAL 489
             |:|.:.|.:: ..:.|            |:...::.|.|  .|.| ||:   |:....|..:..
  Fly   505 PVMEVLFVTLV-TAIICYPNPFTRMNMNELIFLLVSKCSP--GDVT-NPL---CDYKRMNITSGN 562

  Fly   490 WFQTPEATVRSLFHDP-PGSHKILTLALFT-VVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL 552
            .|  .|.|      :| ||.:..:.|.:.| ::...|:..|||:.|..|:|||:.|:||..||::
  Fly   563 SF--IEVT------EPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619

  Fly   553 AM---LTYYVFPQAEF----------LHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604
            .:   ...|.:|...|          :.||.||::||||.||||.|||:||.||:.|.|| ...:
  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTG-GVRY 683

  Fly   605 FFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDS 668
            ..||:.|.:::|||||.. .:||||..|.:|..|.|      ..|...|...|:..|:..|..::
  Fly   684 IVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFL------DSKEEFAHTTLAADVMQPKRNET 742

  Fly   669 ANYIYE----------MLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN-K 722
            .|.|.:          :||:.:|||:|||..     |....:.|.:||..|      :|.:.| |
  Fly   743 LNVITQDSMTVDDVENLLKETEHNGYPVVVS-----RENQYLVGFVLRRDL------NLAIGNAK 796

  Fly   723 RF--WLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFR 785
            |.  .:..:||..|....|    |:::.....|:...:|:      :||.|.....:..:..:||
  Fly   797 RLIEGISSSSIVLFTSSQP----IQNLGPQPLKLKKILDM------APITVTDQTPMETVVDMFR 851

  Fly   786 ALGLRHLLVINHENRIAGIITRRDFI 811
            .||||..|| .|..|:.|:||::|.:
  Fly   852 KLGLRQTLV-THNGRLLGVITKKDVL 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	177/606 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	47/173 (27%)
		CBS repeat	657..763	CDD:341367	28/118 (24%)
		CBS repeat	769..812	CDD:341367	16/43 (37%)
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	164/541 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	46/169 (27%)
		CBS repeat	736..829	CDD:341367	26/107 (24%)
		CBS repeat	835..877	CDD:341367	16/43 (37%)