DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcnk

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_021325439.1	Gene:	clcnk / 393353	ZFINID:	ZDB-GENE-040426-1379	Length:	724	Species:	Danio rerio

Alignment Length:	695	Identity:	170/695 - (24%)
Similarity:	295/695 - (42%)	Gaps:	113/695 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 IRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSI 210
            :.|..:..:||||||::..:|:.:.:| :..:.:||..:|.:          .|:.:|.|.|:..
Zfish    69 MEWYCYALLGIITALMSFFMDMTVAKL-LNAHQWLYGCLKGH----------HLLQFLCWTLYPA 122

  Fly   211 VPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG--LAGGKE 273
            ...|...:....:.|.:||||:|:.::.|.||.:|..:.:..|..|..|:|.::..|  :..||.
Zfish   123 CLCALSTSFAHSVCPYSAGSGVPEARAILLGVDMPDYLSLSNLFAKMFGLICTLAAGSTVFLGKV 187

  Fly   274 GPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHE---KRDFVLGGGAAGVSAAFGAPIGGML 335
            ||.:|...:|.|.::           |:..:.|...:   |.:.::...|.||::.|||||.|:|
Zfish   188 GPFVHLSIMVGAFMN-----------RLHVSCRGGKQRAAKGEMLVVASAVGVASCFGAPISGVL 241

  Fly   336 FSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELP 400
            ||:|...:.::.:.......|:.....|..: ||...|..| |...||.. .|.|.|.|..||:.
Zfish   242 FSIEVMGTHYSVSDYCPCFFAAACGAITFRL-LSVCIGDQD-TIQALFKT-SFSTDLPFQPFEII 303

  Fly   401 IFMILGVTGGLLGA------AWNSLNTKINKFRKRFIPWKIGKVLEAVVVAMMGVTLACLMIY-- 457
            ||.:||:...:|..      .|.....|.||....|:..:  |.|.:.:||.:   |||...|
Zfish   304 IFALLGLFCSILSCIYLLCHRWALRFVKTNKPISTFLATE--KSLYSAIVAFL---LACFTFYHS 363

  Fly   458 ---FINDCRPLGNDPTNNPVQLFCEDNE--YNA---VAALWFQTPEATVRSLFHDPPGSHKILTL 514
               ||      .::.|...:.....|..  ||.   ::||  ..|:.|....: :|||.....||
Zfish   364 AGHFI------ASELTMRQLLTSMLDGTSWYNISQNISAL--PEPQNTFWQAW-NPPGKSYFQTL 419

  Fly   515 ALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQA-----EFLHPGKYALI 574
            ..|.:....|......|.:..|.|:|..:.|||.||.:...::|:....     ..::||.|||.
Zfish   420 TFFIITKVGLLVVACTLPLPAGYFMPVFVYGAAVGRFIGEGSFYLLSGGISSGKSLINPGGYALA 484

  Fly   575 GAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVG-----DYFNEGIYDTQIQVN 634
            |||| ..|.:..|:|.:::.:|.|| :.|:..|.::|.:.:..|.     ..|.:||...: ::.
Zfish   485 GAAA-FSGAVTHTLSPALLAVEMTG-QCSYAVPALVATLVSNAVARAKHRPSFYDGISLIK-RLP 546

  Fly   635 HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGR 699
            |:|.|. ...|:...::.::.:......::..:....:..:||:...:..|||:.     |....
Zfish   547 HLPSLI-RACPKLADVQIKQFVIPAGAVLERSEKLISVQHILKESTDSELPVVES-----RDFSV 605

  Fly   700 VCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFM 764
            :.|.|.||||...||:.   .|:                      .|.::|:|        ...:
Zfish   606 LLGTINRSQLRECLLEH---RNE----------------------DSCKQLEE--------VCCV 637

  Fly   765 NPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            .|..:.:.|..:|.:...|....|.:.|. |....|:.|:||.::
Zfish   638 QPVRLHLTPDSTVKQAHCIMSITGEQRLF-ITESGRLCGVITWKE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	29/136 (21%)
		ClC_6_like	115..639	CDD:239657	139/523 (27%)
		Voltage_CLC	213..620	CDD:279048	118/437 (27%)
		CBS	653..811	CDD:223591	29/157 (18%)
clcnk	XP_021325439.1	ClC_1_like	70..550	CDD:239655	138/521 (26%)
clcnk	XP_021325439.1	CBS_pair	582..685	CDD:326561	29/139 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810