DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and Clcn6

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001099949.1	Gene:	Clcn6 / 295586	RGDID:	1305379	Length:	870	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	289/819 - (35%)
Similarity:	434/819 - (52%)	Gaps:	134/819 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.|..:. |..:.:..:...|.:.::|::...||:.|.|:...:|..:...:..|:
  Rat    47 DYESLDYDRCINDPYL-EVLETMDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKF 110

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .|.:..|...|..||...:...|.|:::..|||:.||||||::|.|||||
  Rat   111 GVVQTSVEE------CSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGV 169

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.|||::||..|..||:.||.|||..||||||||:||||.||:.|.:|.:..|....|..||.
  Rat   170 KVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRS 234

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.
  Rat   235 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 299

  Fly   371 YHGLNDFTFTGLFNLGKF---DTPLK---FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|   |:..|   :...:|..|:::||.||||||.:|.||.::.|:|.|
  Rat   300 FGSWGAFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMR 364

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPL------GN---------DPTNNPVQ- 475
            .:   | |:.:|||:::|:::...:..:....:.:||.:      ||         :..|:.::
  Rat   365 NVHPKP-KLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKT 428

  Fly   476 LFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIP 540
            .||.::.||.:|.|:|.:.|:.:..|||. .|:...:|||||..:|::::|.|||.:|..|:|:|
  Rat   429 FFCPNDTYNDMATLFFNSQESAILQLFHQ-DGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVP 492

  Fly   541 TALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604
            :.|.|||:|||:| :|..|:  ....|:.|.:|||||||.||||:||||||:|||:|:|. |.::
  Rat   493 SLLCGAAFGRLVANVLKSYI--GLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EITY 554

  Fly   605 FFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSA 669
            ..|:::.|:.|||.||:||:||||..|.:..||:|.||...:...|:|.:|:...:..:......
  Rat   555 GLPIMVTLMVAKWTGDFFNKGIYDIHIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRI 619

  Fly   670 NYIYEMLKKCDHNGFPVVDD----------------------------VCGDRRSEGR------- 699
            ..:..:|:...|:.||||.:                            ..|::|..|:
  Rat   620 QSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPS 684

  Fly   700 -----VC----------------------------------------------------GIILRS 707
                 ||                                                    |::|||
  Rat   685 SELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRS 749

  Fly   708 QLIVILLKSL-YVENK-RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIR 770
            ||:.:|::.: |.|:: ....|..|.....:.|||||.|..:..........||::.:|||||..
  Rat   750 QLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFT 814

  Fly   771 VNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            |:|:..|.::|.:||.:|||||.|:|....|.|||||.:
  Rat   815 VSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHN 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	54/230 (23%)
		ClC_6_like	115..639	CDD:239657	228/551 (41%)
		Voltage_CLC	213..620	CDD:279048	193/434 (44%)
		CBS	653..811	CDD:223591	55/251 (22%)
Clcn6	NP_001099949.1	ClC_6_like	49..589	CDD:239657	228/551 (41%)
		Voltage_CLC	140..571	CDD:279048	194/435 (45%)
		CBS	609..656	CDD:214522	6/46 (13%)
		CBS_pair_EriC_assoc_euk_bac	<801..854	CDD:239964	26/53 (49%)
		CBS	804..>854	CDD:223591	24/50 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730