DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-b and Clcn2

DIOPT Version :10

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_058833.1 Gene:Clcn2 / 29232 RGDID:2361 Length:907 Species:Rattus norvegicus


Alignment Length:932 Identity:219/932 - (23%)
Similarity:366/932 - (39%) Gaps:261/932 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 SALARRATLSGNN---HLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAA 109
            :|.|..||::|..   ..|...|.|:.|..:  .::.......:....:...||   .:...:|.
  Rat     3 AATAAAATVAGEGMEPRALQYEQTLMYGRYT--QELGAFAKEEAARIRLGGPEP---WKGSPSAR 62

  Fly   110 STPNYESLDY--------EVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTID 166
            :||  |.|:|        .:|....     .|.|..|  :.:|   ||..:.:|::.||::..:|
  Rat    63 ATP--ELLEYGQSRCARCRICSVRC-----HKFLVSR--VGED---WIFLVLLGLLMALVSWAMD 115

  Fly   167 IIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSG 231
            ..| .:.::...::...:..|:          |:.||.|:.:.:|.:.|.|.....:.|...|||
  Rat   116 YAI-AVCLQAQQWMSRGLNTNI----------LLQYLAWVTYPVVLITFSAGFTQILAPQAVGSG 169

  Fly   232 IPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFL 296
            ||::|:.|.||.:...:.:||...|.||:..::..|:..|||||.:|..::.||.:|:     ||
  Rat   170 IPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSK-----FL 229

  Fly   297 KDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISV 361
            ..|.  ..:.::....:.:....|.||...|.|||||:|||:|..::|:.....||...|:..|.
  Rat   230 SLFG--GIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSA 292

  Fly   362 FTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKI--- 423
            |...::  |....::.|.|.||.. :|.....||..|||.|.::|:..|..||.:..||.||   
  Rat   293 FIFRVL--AVWNRDEETITALFKT-RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQV 354

  Fly   424 ---NKFRKRFIPWKIGKVLEAVVVAMMGVTLAC------LMIYFINDCRPLGNDPTNNPVQLF-- 477
               .|...||:..|  ::|...:|.::..||..      .|...::....|        |.||  
  Rat   355 MRKQKTINRFLMKK--RLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETL--------VTLFDN 409

  Fly   478 --------CEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVS 534
                    .||....:.:..|             .||.::..|||.:|.::.:.:|.....:.|.
  Rat   410 RTWVRQGLVEDLGAPSTSQAW-------------SPPRANVFLTLVIFILMKFWMSALATTIPVP 461

  Fly   535 LGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLH---------PGKYALIGAAANLGGVLRMTISL 590
            .|.|:|..::|||:|||:.......||..  :|         ||.||::|||| |.|.:..|:|.
  Rat   462 CGAFMPVFVIGAAFGRLVGESMAAWFPDG--IHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVST 523

  Fly   591 SVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVN---HVPMLTWEPLPQYKGLKA 652
            :||:.|.|| :.:...|::||:|.|..|.......:||:.|::.   ::|.|.|....||: ::.
  Rat   524 AVIVFELTG-QIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYR-VRV 586

  Fly   653 REILSKPV----ICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGR------------VC 701
            .:|:.:.|    :....||        |:...|             |::||            :.
  Rat   587 EDIMVRDVPHVALSCTFRD--------LRLALH-------------RTKGRMLALVESPESMILL 630

  Fly   702 GIILRSQLIVILLKSLYVENKRFWL-------------------PETSI---------------- 731
            |.|.|||::.:|...|....:|..:                   .||||                
  Rat   631 GSIERSQVVALLGAQLSPARRRQHMQKLRKAQMSPPSDQESPPSSETSIRFQVNTEDSGFPGAHG 695

  Fly   732 QTFRDLYP---RFPS-----------------------------------------------IKS 746
            ||.:.|.|   |.||                                               :|.
  Rat   696 QTHKPLKPALKRGPSNATSLQEGTTGNMESAGIALRSLFCGSPPLESTTSELEKSESCDKRKLKR 760

  Fly   747 VR------------------------KLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRAL 787
            ||                        :|||.:|::   ...::|:|.::....|:.:...||..|
  Rat   761 VRISLASDSDLEGKMSPEEILEWEEQQLDEPVNFS---DCKIDPAPFQLVERTSLHKTHTIFSLL 822

  Fly   788 GLRHLLVINHENRIAGIITRRD 809
            |:.|..|.: ..|:.||:|.::
  Rat   823 GVDHAYVTS-IGRLIGIVTLKE 843

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 ClC_6_like 115..639 CDD:239657 153/565 (27%)
CBS_pair_voltage-gated_CLC_euk_bac 652..813 CDD:341367 48/283 (17%)
CBS repeat 657..763 CDD:341367 34/230 (15%)
CBS repeat 769..812 CDD:341367 11/41 (27%)
Clcn2NP_058833.1 Essential for channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 22..40 3/19 (16%)
Modulates channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 42..55 2/15 (13%)
ClC_1_like 96..573 CDD:239655 145/527 (28%)
Selectivity filter part_1. /evidence=ECO:0000250 167..171 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 209..213 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 463..467 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 585..847 CDD:341367 48/284 (17%)
CBS repeat 591..798 CDD:341367 34/230 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..720 12/69 (17%)
CBS repeat 804..846 CDD:341367 11/41 (27%)