DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and Clcn7

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_036060.1	Gene:	Clcn7 / 26373	MGIID:	1347048	Length:	803	Species:	Mus musculus

Alignment Length:	823	Identity:	387/823 - (47%)
Similarity:	528/823 - (64%)	Gaps:	69/823 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDRKA--LITLDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLLD 64
            ||.:.  |:...|:.. |:.|::  ..|||        |..|    |.|||.|...:  ||..||
Mouse    16 DDEEGAPLLRRTGQPD-EETPLL--NGAGP--------GARQ----SHSALFRIGQM--NNVELD 63

  Fly    65 DS--QPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLF 127
            |.  .|.:...::.|.:||.|             |.:..|:          ||||||:..||.||
Mouse    64 DELLDPEVDPPHTFPKEIPHN-------------EKLLSLK----------YESLDYDNSENQLF 105

  Fly   128 QDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSD 192
            .:|:| |:........:|.||:|...|||:|.|:||.|||::|.|:..|    |..:|:|:
Mouse   106 LEEER-RINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLK----YRVIKDNI---- 161

  Fly   193 ASDR-----DLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKT 252
              |:     .|....|.|...:...|..|:.:|.:|||:.|||||||:|.:|||||||.:||:||
Mouse   162 --DKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKT 224

  Fly   253 LAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLG 317
            |.:|..|||.|||||||.||||||||:|:|:|||||||:||:..:||:||:.||.|.||||||..
Mouse   225 LVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSA 289

  Fly   318 GGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHG-LNDFTFTG 381
            |.|||||||||||:||:||||||.||||||.|.||...||:||.||||.|||.||| :.|.:..|
Mouse   290 GAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPG 354

  Fly   382 LFNLGKFDT-PLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVA 445
            |.|.|:||: .:.:...|:|:|:.:||.||:|||.:|:||..:..||.|:|.....:|:||::||
Mouse   355 LINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVA 419

  Fly   446 MMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHK 510
            .:..|:|.::||...||:||.....:.|:||||.|.|||::||.:|.|||.:|.|||||||||:.
Mouse   420 AVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYN 484

  Fly   511 ILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLHPGKYALIG 575
            .:||.|||:||:.|:|.|:||.||.|||||:.|:|||||||..:...|:...|.:..||||||:|
Mouse   485 PMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMG 549

  Fly   576 AAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLT 640
            |||.|||::|||:||:||:||.|. ..::.||:::.|::||.|||.|.||:||..||:..||.|.
Mouse   550 AAAQLGGIVRMTLSLTVIMMEATS-NVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH 613

  Fly   641 WEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLK--KCDHNGFPVVDDVCGDRRSEGRVCGI 703
            ||.......|.|||::|.||.|::.|:....|.::|.  ..:|||||||:|| ||.: ..|:.|:
Mouse   614 WEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDV-GDTQ-PARLQGL 676

  Fly   704 ILRSQLIVILLKSLYVENKRFWLPE--TSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNP 766
            ||||||||:|...::||.....|.:  ..::.|||.|||||.|:|:....::...|:|||.||||
Mouse   677 ILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNP 741

  Fly   767 SPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            ||..|....|:||:|::|||||||||:|:::.|::.|::||:|
Mouse   742 SPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKD 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	66/140 (47%)
		ClC_6_like	115..639	CDD:239657	279/530 (53%)
		Voltage_CLC	213..620	CDD:279048	232/408 (57%)
		CBS	653..811	CDD:223591	74/161 (46%)
Clcn7	NP_036060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		10/40 (25%)
		ClC_6_like	93..618	CDD:239657	282/536 (53%)
		Selectivity filter part_1. /evidence=ECO:0000250	201..205		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	243..247		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	510..514		3/3 (100%)
		CBS_pair_voltage-gated_CLC_euk_bac	624..788	CDD:341367	75/163 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841851
Domainoid	1	1.000	466	1.000	Domainoid score	I466
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56546
Inparanoid	1	1.050	680	1.000	Inparanoid score	I714
Isobase	1	0.950	-	0	Normalized mean entropy	S2295
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		oto92593
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	1	1.100	-	-	LDO	PTHR11689
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3132
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750