DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-b and Clcn6

DIOPT Version :9

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_036059.1 Gene:Clcn6 / 26372 MGIID:1347049 Length:870 Species:Mus musculus


Alignment Length:819 Identity:289/819 - (35%)
Similarity:434/819 - (52%) Gaps:134/819 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.|..:. |..:.:..:...|.:.::|::...||:.|.|:...:|..:...:..|:
Mouse    47 DYESLDYDRCINDPYL-EVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKF 110

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .|.:..|...|..||...:...|.|:::..|||:.||||||::|.|||||
Mouse   111 GVVQTSVEE------CSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGV 169

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.|||::||..|..||:.||.|||..||||||||:||||.||:.|.:|.:..|....|..||.
Mouse   170 KVPGIVRLRTLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRS 234

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.  
Mouse   235 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 299

  Fly   371 YHGLNDFTFTGLFNLGKF---DTPLK---FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|   |:..|   :...:|..|:::||.||||||.:|.||.::.|:|.|
Mouse   300 FGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMR 364

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPL------GN---------DPTNNPVQ- 475
            .:   | |:.:|||:::|:::...:..:....:.:||.:      ||         :..|:.:: 
Mouse   365 NVHPKP-KLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKA 428

  Fly   476 LFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIP 540
            .||.::.||.:|.|:|.:.|:.:..|||. .|:...:|||||.::|::|:|.|||.:|..|:|:|
Mouse   429 FFCPNDTYNDMATLFFNSQESAILQLFHQ-DGTFSPVTLALFFILYFLLACWTFGTSVPSGLFVP 492

  Fly   541 TALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604
            :.|.|||:|||:| :|..|:  ....|:.|.:|||||||.||||:||||||:|||:|:|. |.::
Mouse   493 SLLCGAAFGRLVANVLKSYI--GLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EITY 554

  Fly   605 FFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSA 669
            ..|:::.|:.|||.||.||:||||..|.:..||:|.||...:...|:|.:|:...:..:......
Mouse   555 GLPIMVTLMVAKWTGDLFNKGIYDVHIGLRGVPLLEWETDVEMDKLRASDIMEPNLTYVYPHTRI 619

  Fly   670 NYIYEMLKKCDHNGFPVVDD----------------------------VCGDRRSEGR------- 699
            ..:..:|:...|:.||||.:                            ..|::|..|:       
Mouse   620 QSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPS 684

  Fly   700 -----VC----------------------------------------------------GIILRS 707
                 ||                                                    |::|||
Mouse   685 SELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRS 749

  Fly   708 QLIVILLKSL-YVENK-RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIR 770
            ||:.:|::.: |.|:: ....|..|.....:.|||:|.|..:..........||::.:|||||..
Mouse   750 QLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFT 814

  Fly   771 VNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            |:|:..|.::|.:||.:|||||.|:|....|.|||||.:
Mouse   815 VSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHN 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 CBS_pair_EriC_assoc_euk_bac 674..811 CDD:239964 53/230 (23%)
ClC_6_like 115..639 CDD:239657 229/551 (42%)
Voltage_CLC 213..620 CDD:279048 194/434 (45%)
CBS 653..811 CDD:223591 54/251 (22%)
Clcn6NP_036059.1 ClC_6_like 49..589 CDD:239657 229/551 (42%)
Voltage_CLC 140..571 CDD:279048 195/435 (45%)
Selectivity filter part_1. /evidence=ECO:0000250 156..160 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 198..202 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 488..492 2/3 (67%)
CBS 609..656 CDD:214522 6/46 (13%)
CBS_pair_EriC_assoc_euk_bac <801..854 CDD:239964 26/53 (49%)
CBS 804..>854 CDD:223591 24/50 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53783
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000220
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101210
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1393
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

Return to query results.
Submit another query.