DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-b and Clcn5

DIOPT Version :9

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:XP_038955439.1 Gene:Clcn5 / 25749 RGDID:2362 Length:816 Species:Rattus norvegicus


Alignment Length:849 Identity:242/849 - (28%)
Similarity:384/849 - (45%) Gaps:194/849 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 DDSQPL---LMGNNSVPPDIPINGSAGSPNRNIN-SSEPIFHLRSRTAAASTPNYESLDYEVCEN 124
            ||..||   :.||.|..     .|..||.||.:: ..|||      ....:..::.::|: |.|.
  Rat    44 DDVPPLDREIEGNKSYN-----GGGIGSSNRIMDFLEEPI------PGVGTYDDFNTIDW-VREK 96

  Fly   125 TLFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRK---- 176
            :..:|..|: :|.:         .|:......|::.:.||:::..:|..|||....::..|    
  Rat    97 SRDRDRHRE-ITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGIC 160

  Fly   177 -----------------YTF-------LYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGA 217
                             .||       .:||..:.:..:|......::.|..::|::::......
  Rat   161 TGGFWFNHEHCCWNSEHVTFEDRDKCPEWNSWSQLIISTDQGAFAYIVNYFMYVLWALLFAFLAV 225

  Fly   218 AMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH---- 278
            ::|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|    
  Rat   226 SLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACC 290

  Fly   279 AGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAAGVSAAFGAPIGGMLFSLEEAA 342
            .|.::.               ..|..:|.:..||..|| ...|||||.||||||||:||||||.:
  Rat   291 CGNILC---------------HCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVS 340

  Fly   343 SFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMIL 405
            .::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :..|||..|::|
  Rat   341 YYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--WHLFELVPFIVL 395

  Fly   406 GVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLAC-----------LMIY 457
            |:.|||.||.:  :.|.|...|||... ::||  |:|.::|..:...||.           |:..
  Rat   396 GIFGGLWGALF--IRTNIAWCRKRKTT-QLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELISE 457

  Fly   458 FINDCRPLGNDPTNNPVQLFCE-DNEYN---------------AVAALWFQTPEATVRSLFHDPP 506
            ..|||..|.:..       .|: :|.:|               ..:|:|                
  Rat   458 LFNDCGLLDSSK-------LCDYENHFNTSKGGELPDRPAGVGVYSAMW---------------- 499

  Fly   507 GSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VFPQ 562
                  .|||..::..|::..|||:.:..|:|||:..|||..||||.:    |.||     :|..
  Rat   500 ------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNS 558

  Fly   563 -----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF 622
                 |:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|..
  Rat   559 WCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSKWVADAL 622

  Fly   623 -NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKCD 680
             .|||||..|::|..|.|..:....:|.| |.:::    :.|::.:..:||...  :..::.:..
  Rat   623 GREGIYDAHIRLNGYPFLEAKEEFAHKTL-AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETT 686

  Fly   681 HNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN---KRFWLPETSIQTFRDLYPRFP 742
            ::|||||..     |...|:.|.:||..||:      .:||   |:..:..|||..|.:..|..|
  Rat   687 YSGFPVVVS-----RESQRLVGFVLRRDLII------SIENARKKQDGVVSTSIIYFTEHSPPMP 740

  Fly   743 SIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITR 807
            .....         |:.|...::.||..|.....:..:..|||.||||..|| .|..|:.||||:
  Rat   741 PYTPP---------TLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV-THNGRLLGIITK 795

  Fly   808 RDFI 811
            :|.:
  Rat   796 KDVL 799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 CBS_pair_EriC_assoc_euk_bac 674..811 CDD:239964 42/139 (30%)
ClC_6_like 115..639 CDD:239657 178/611 (29%)
Voltage_CLC 213..620 CDD:279048 147/456 (32%)
CBS 653..811 CDD:223591 45/166 (27%)
Clcn5XP_038955439.1 ClC_3_like 142..640 CDD:239656 168/555 (30%)
CBS_pair_voltage-gated_CLC_euk_bac 651..801 CDD:341367 47/171 (27%)
CBS repeat 657..752 CDD:341367 26/114 (23%)
CBS repeat 758..800 CDD:341367 17/43 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000220
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

Return to query results.
Submit another query.