DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and Clcn1

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_037279.1	Gene:	Clcn1 / 25688	RGDID:	2360	Length:	994	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	183/780 - (23%)
Similarity:	324/780 - (41%)	Gaps:	194/780 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QKEAGPTSKA--VQDFGLHQREEPSTSALARRATLSGNNHLLDDSQPLLMGNNSVPPDIPINGSA 86
            :|:.||...|  .|.:| |.:|:.|..|..|
  Rat    47 RKDLGPRHNAHPTQIYG-HHKEQYSYQAQDR---------------------------------- 76

  Fly    87 GSPNRNINSSEPIFHLRSRTAAASTPNYESLD---YEVCENTLFQDEQ--RKRLTERFSLRKDII 146
            |.|.:..:||                ..:|||   |..|::.:.:..:  |::|.|
  Rat    77 GIPKKTDSSS----------------TVDSLDEDHYSKCQDCVHRLGRVLRRKLGE--------- 116

  Fly   147 RWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIV 211
            .||..:.:|::.||::..:|.:..: |::.|.:.|..::.::||.          ||.|:.|.::
  Rat   117 DWIFLVLLGLLMALVSWCMDYVSAK-SLQAYKWTYAQMQPSLPLQ----------YLAWVTFPLI 170

  Fly   212 PVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPM 276
            .:.|.|.....|.|...|||||::|:.|.||.:...:.:|....|.:.:...:..|:..|||||.
  Rat   171 LILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPF 235

  Fly   277 IHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            :|..::.||.:|:     |:..|.  ..:...:...|.:..|.|.||...||.|:||:|||:|..
  Rat   236 VHIASICAAVLSK-----FMSMFS--GVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVT 293

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFDYFELPIFMIL 405
            ::::.....||...|:..|.|...::  |....:..|.|.||... :.|.|  ||..|||.|.::
  Rat   294 STYFAVRNYWRGFFAATFSAFVFRVL--AVWNKDAVTITALFRTNFRMDFP--FDLKELPAFAVI 354

  Fly   406 GVTGGLLGAAWNSLNTKI------NKFRKRFI--------------------PWKIGKVL----- 439
            |:..|.|||.:..|:.::      :|...:|:                    |..:|:.:
  Rat   355 GICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELM 419

  Fly   440 --EAVVVAMMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLF 502
              ||:.......|    .:..|.|.:.||.                   :|:|.. |:..|
  Rat   420 PREAISTLFDNNT----WVKHIGDPKSLGQ-------------------SAVWIH-PQVNV---- 456

  Fly   503 HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQA---- 563
                    ::.:.||.|:.:.:|.....:.:..|.|:|..::|||:|||:..:...:||:.
  Rat   457 --------VIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFD 513

  Fly   564 EFLH---PGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEG 625
            :.::   ||.||:||||| |.|.:..|:|.:||..|.|| :.:...|:::|:|.|..|.......
  Rat   514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTG-QIAHILPMMVAVILANMVAQSLQPS 576

  Fly   626 IYDTQIQVN---HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVV 687
            :||:.|||.   ::|.|.|..|.::. :...:|:.:.|..:....:...:..:|:.......|:|
  Rat   577 LYDSIIQVKKLPYLPDLGWNQLSKFT-IFVEDIMVRDVKFVSASCTYGELRNLLQTTTVKTLPLV 640

  Fly   688 DDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSVRKLDE 752
            |.     :....:.|.:.||:|..:|.:.|..|.:        ::..:|:         .|||.|
  Rat   641 DS-----KDSMILLGSVERSELQSLLQRHLCAERR--------LKAAQDM---------ARKLSE 683

Fly 753 752
Rat 684 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	16/79 (20%)
		ClC_6_like	115..639	CDD:239657	147/572 (26%)
		Voltage_CLC	213..620	CDD:279048	118/447 (26%)
		CBS	653..811	CDD:223591	18/100 (18%)
Clcn1	NP_037279.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..61		4/13 (31%)
		ClC_1_like	117..592	CDD:239655	138/534 (26%)
		Voltage_CLC	170..571	CDD:279048	118/449 (26%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair	610..>665	CDD:301603	10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..769
		CBS_pair_EriC_assoc_euk_bac	<827..875	CDD:239964
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..923
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810