Protein Alignment ClC-b and SPOM_SPBC19C7.11

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_596167.2
• Gene: SPOM_SPBC19C7.11 / 2540750
• PomBaseID: SPBC19C7.11
• Length: 766
• Species: Schizosaccharomyces pombe
• Alignment Length: 705
• Identity: 195/705 - (27%)
• Similarity: 322/705 - (45%)
• Gaps: 102/705 - (14%)

  Fly   148 WIIFIQIGIITALIACTIDIIIEELS-IRK-YT---FLYNS-----VKENVPLSDASDR----DL 198
            |.|...||......|..:||:...|| ||: |.   :.||.     ..|.:..|..:.:    ..
pombe    79 WFILSIIGTTVGFAAYMLDIVTSWLSDIRRGYCTSHWYYNEKFCCWYSETMGSSCTAWKPWTYKF 143

  Fly   199 LIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITS 263
            .:.||.:..|:::.|...|.||..:.|:.|||||.::|..::|......:..:.:.||.:|:..:
pombe   144 SLNYLIYTAFALLFVLCAAIMVRDVAPLAAGSGISEIKCIISGFLRDSFLSFRVMLVKCVGLPLA 208

  Fly   264 VVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEK-RDFVLGGGAAGVSAAF 327
            :..||:.|||||.:|....:...||           :|||..|:...: ||..:...|:||:.||
pombe   209 IASGLSVGKEGPSVHLATTIGHNIS-----------KIFKYAREGSIRYRDICVASAASGVAVAF 262

  Fly   328 GAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPL 392
            |:||||:||.:||.:..::..:|       :.|.|.....:...|.||.|. ||...|.:.....
pombe   263 GSPIGGVLFGIEEMSGGYDPKMI-------VYSFFCCLSAVGVLHMLNPFR-TGQVVLFEVRYSG 319

  Fly   393 KFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIP-WKIGKVLEAVVVAMMGVTLACLMI 456
            .:.:|||..|..||:.|||.|.....|...|.|.||:::. |   .||:|..     ||:...::
pombe   320 SWHFFELLFFCFLGIFGGLYGEFVMRLFFLIQKLRKKYLSRW---GVLDAAF-----VTVITSLV 376

  Fly   457 YFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVY 521
            .|:|....|  |.|.....||.|....::...:....|....::..        :|.:|.|....
pombe   377 SFLNPWLRL--DMTLGMELLFQECKSSSSPELINLCDPSLRTKNTI--------LLLIATFARTI 431

  Fly   522 YVLSCATFGLNVSLGVFIPTALVGAAWG---RLLAMLTYYVFPQA----------EFLHPGKYAL 573
            :|  ..::|..|..|:|:|:..|||::|   .|:|.:.|..||.:          ..:.||.|||
pombe   432 FV--TFSYGAKVPAGIFVPSMAVGASFGYMIGLIAEMIYQRFPNSVLFLACHGSESCITPGTYAL 494

  Fly   574 IGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNE-GIYDTQIQVNHVP 637
            :||||:|.|::.:|:::.||:.|.||. .:|..|.::.:..|..:|:...: ||.|..|::|.:|
pombe   495 LGAAASLSGIMHLTVTIVVIMFELTGA-LNFILPTVLVVALANSIGNMLGKTGIADRSIEINGLP 558

  Fly   638 MLTWEPLPQYK-----GLKAREILSKPVICI-KIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRS 696
            :|  ||.....     .:...|:::..:|.| .|..:...:..|::..|.:|:|||    .|.||
pombe   559 LL--EPEKSINSSNTINIPITEVMASNLITIPSIGFTWRKLLGMMEGYDFSGYPVV----LDSRS 617

  Fly   697 EGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSV-----RKLDEKINY 756
             ..:.|.:.:|.     |||.:...|.    |.|. || |....|..:.||     .|..|  :.
pombe   618 -NYLIGYLKKSS-----LKSSFEAAKL----EPSF-TF-DQQLCFGKVDSVGDSKSSKFGE--SD 668

  Fly   757 TVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .:|||.:|:.:||.|....|:..:..:|..|. ..::.|..:..:.|:|:::|.:
pombe   669 RIDLSAYMDVNPISVLHTQSIANVAVLFEVLS-PSVIFIEKDGNLVGLISKKDLL 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	149/520 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	43/166 (26%)
		CBS repeat	657..763	CDD:341367	31/111 (28%)
		CBS repeat	769..812	CDD:341367	9/43 (21%)
SPOM_SPBC19C7.11	NP_596167.2	ClC_3_like	86..560	CDD:239656	146/513 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	575..724	CDD:341367	43/167 (26%)
		CBS repeat	581..675	CDD:341367	31/111 (28%)
		CBS repeat	681..723	CDD:341367	9/43 (21%)