Protein Alignment ClC-b and clh-4

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001024886.1
• Gene: clh-4 / 180687
• WormBaseID: WBGene00000531
• Length: 1085
• Species: Caenorhabditis elegans
• Alignment Length: 757
• Identity: 195/757 - (25%)
• Similarity: 318/757 - (42%)
• Gaps: 150/757 - (19%)

  Fly     7 LITLDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLLDDSQPLLM 71
            |:..|.||   ||..|:....              |:..|.|||.|  |.|.|:......:.:::
 Worm    30 LVADDDES---DDNCIVSPRF--------------RKSSSRSALVR--TTSFNHKQYRSIKEMII 75

  Fly    72 GNNSVPPDIPINGSAGSPNRNINSSEPI-FHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRL 135
            .....|..   ||..|..|.:.:|...: |.|.:   ....|.:..      ..:|:...:..|:
 Worm    76 DLKQEPGK---NGLHGLENGSNHSDRKVTFTLEN---DLEFPKFRK------NRSLWLRMEMNRI 128

  Fly   136 TER-FSLRKDIIRWIIFIQIGIITALIACTIDIII---EELSIRKYTFLYNSVKENVPLSDASDR 196
            ..: .||...:..|:....:|:..|.|:..:|:::   :|:. ||...:||..        .||:
 Worm   129 KHKLISLSYLLSDWMFLALLGVAVAFISILVDMMVFSFQEIQ-RKTVSIYNIY--------GSDQ 184

  Fly   197 DLLI---PYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAI 258
            ..|:   ..|.|..:.|..||..|..|.|:.|...|||||::|:.:.||.:...:.:|||..|..
 Worm   185 SYLLWGCGLLGWCGYMIGLVAASACFVHYVAPQAIGSGIPEMKTIIRGVILVDYLTLKTLVSKIF 249

  Fly   259 GVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGV 323
            ||..::..|:..||.||.:|..:|||       :...|...:...|:|::..:.:.:....|.||
 Worm   250 GVAMALGSGVPIGKMGPFVHIASVVA-------NQMCLLAAKFDSAYREESRRMECLAAACAVGV 307

  Fly   324 SAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKF 388
            :..|.:|:||:|||:|....:::....||...|:.....|:.: |.||....:.|.:..     :
 Worm   308 ACTFSSPVGGVLFSIEVTTMYFSVRSYWRGFFAACCGATTIRL-LRAYVVETEVTVSAF-----Y 366

  Fly   389 DTPLKFDYF---ELPIFMILGVTGGLLGAAWNSL---------NTKINK--FRKRFIPWKIGKVL 439
            .|..:.|.|   |||:|.:||:..|:|||.:.||         |.:..|  |::.:|.:.|  |:
 Worm   367 QTSFRPDAFSVDELPLFALLGLLCGILGAGYISLYRCVVLFLRNNQYAKMVFQRHWIVYPI--VI 429

  Fly   440 EAV--VVA-------------MMGVTLA-----CLMIYFINDCRPLGNDPTNNPVQLFCEDNEYN 484
            ..:  ||:             ..|..|.     |..|...:|             .|.|....|:
 Worm   430 SCIFSVVSYPHGLGMFSTGRIKFGTNLRDFFANCSFIVTSSD-------------DLVCGAEIYS 481

  Fly   485 AVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWG 549
            .    |...              .:.:|.|.||.:|:::.|..:|.|.|..|||:|..::|||.|
 Worm   482 H----WLNR--------------GNILLLLFLFVLVHFIFSIISFTLPVPSGVFLPVFVLGAAIG 528

  Fly   550 RLLAMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALIS 614
            |....:..........:|||.||::||||....|.. |:|:||::.|.|| :..|..|::|:::.
 Worm   529 RFYGEIIGLALEDIHIIHPGIYAIVGAAAFSASVTH-TVSVSVMIFEITG-QLHFILPVMISVML 591

  Fly   615 AKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGL----KAREILSKPVICI-KIRDSANYIYE 674
            :..|..|.....:||.|::.|:|.|  ..:|....|    .|..|:..||..| ||.     .|.
 Worm   592 SNAVCAYLQPSFFDTIIKIKHLPFL--PDIPPSNNLVHTTYAEHIMVTPVKFITKIT-----TYN 649

  Fly   675 MLKKCDHNG---FPVVDDVCGDRRSEGRVCGIILRSQLIVIL 713
            .:::....|   |||||.     ::...:.|.:.|..|.|:|
 Worm   650 EIREAVQTGLRLFPVVDS-----KNSQMLIGTVSRRYLTVLL 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	148/564 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	19/66 (29%)
		CBS repeat	657..763	CDD:341367	17/61 (28%)
		CBS repeat	769..812	CDD:341367
clh-4	NP_001024886.1	ClC_1_like	141..618	CDD:239655	145/535 (27%)
		CBS_pair_SF	631..>686	CDD:449531	18/64 (28%)
		CBS repeat	636..685	CDD:341358	15/58 (26%)
		CBS_pair_SF	<885..945	CDD:449531
		CBS repeat	902..944	CDD:341358