DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clh-5

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_495940.1	Gene:	clh-5 / 174449	WormBaseID:	WBGene00000532	Length:	797	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	225/881 - (25%)
Similarity:	377/881 - (42%)	Gaps:	219/881 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RRATLSGNNHLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRT-----AAAST 111
            |.:||...     |...|.....|....:.:....||.:.:.|....|..:|.:|     ...:.
Worm     6 RSSTLGST-----DDVELEPSGTSATIHLDMTAGGGSSSSDFNPFGAIDDVRFKTDDDLPDVMAP 65

  Fly   112 P------NYESLDYEVCENTLFQDEQRKRLTERFSLRKDI--------------IRWIIFIQIGI 156
            |      ::.::|::       :|..|.||..:...:|.:              ..||..:.:|:
Worm    66 PFFSKYGDFHTIDWQ-------RDLARDRLRHKMISKKKVDFPLGLLQSGWDAGAGWICVLFVGL 123

  Fly   157 ITALIACTIDIIIEELSIRKY--------------------TF-----------------LYNSV 184
            .....|..|||....:|..|.                    ||                 .|||
Worm   124 AAGATAGIIDIGARWMSDLKTGVCADRFWLDHEHCCWSSNDTFYKDDDCKAWTKWPWMLNYYNS- 187

  Fly   185 KENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIE---PITAGSGIPQVKSYLNGVKIPR 246
                       ...|..:|.|:.:....||.....|.:::   |...|||||::|..|:|..|..
Worm   188 -----------SSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPYACGSGIPEIKCILSGFVIRG 241

  Fly   247 IVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF-RDDHE 310
            .:...|..:|::|:|.|...||:.||||||:|....:      |...::|     |..: .::.:
Worm   242 YLGKWTFIIKSVGLILSSASGLSLGKEGPMVHLACCI------GNIFSYL-----FPKYGLNEAK 295

  Fly   311 KRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLN 375
            ||:.:....|||||.||||||||:|||||||:.::....:||:...::::...|..|       |
Worm   296 KREILSASAAAGVSVAFGAPIGGVLFSLEEASYYFPLKTMWRSFFCALVAGIILRFV-------N 353

  Fly   376 DF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKV 438
            .|  ..|.||::   |..:|:.:.||..|.|||:.||::|:.:...|.:.::|||.      .|:
Worm   354 PFGSNQTSLFHV---DYMMKWTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRKN------SKM 409

  Fly   439 LEA-VVVAMMGVTLACLMIYFINDCRPLGNDPTNNPV-QLF--CEDNEYNAVAALWFQTPEATVR 499
            |.. .:..:|.:||....|.:.|   |.......:.: |||  |||           |..|.::.
Worm   410 LGGNPIYEVMLITLVTAAISYFN---PFTRKSAQSMIQQLFDRCED-----------QIDEDSLC 460

  Fly   500 SLFHDPPGSHKILTLA----LFTVVY-YVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYV 559
            .       .:|.|::|    |:.::: :|::..|||:.|..|:|:|:..:||..||:|.:....:
Worm   461 D-------QNKALSIAFGQLLWALIFKFVITIFTFGIKVPCGLFVPSIGMGAIAGRILGITVDQI 518

  Fly   560 F--PQA--------------EFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPL 608
            |  .||              :.:.||.||::||||.||||.|||:||.||:.|.|| ...|..|.
Worm   519 FRAVQATPGHSDYFTCQIGKDCVMPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTG-SLEFIVPT 582

  Fly   609 IIALISAKWVGDYFNE-GIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANY- 671
            ::|.:.:||:||..:: |||:..|::|..|.|  :...:|........:.:|.|..::.|..:.
Worm   583 MVATMFSKWIGDGISKMGIYEAHIELNGYPFL--DSKGEYPYSTVASQVMRPSIHRQVADEMSMS 645

  Fly   672 ---------------------IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLK 715
                                 :..:|::.|.||||||..     ::...:.|.|.|..:::
Worm   646 DLRELKNELSVITESGMTLGDLESLLRQTDFNGFPVVVS-----QNSMHLVGFITRRDILL---- 701

  Fly   716 SLYVENK-RFWLPETSIQTFR----DLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHD 775
            :|:...| :.::...||..|.    |..|..|:...:||:             ::.:|:.|....
Worm   702 ALHTARKTQPYVVTNSIAYFSDGVPDAMPGGPAPLRLRKI-------------LDMAPMTVTDQT 753

  Fly   776 SVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .:..:..:||.|||||:||..: .::.||||::|.:
Worm   754 PMETVIDMFRKLGLRHVLVTKN-GKVLGIITKKDIL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	37/141 (26%)
		ClC_6_like	115..639	CDD:239657	170/606 (28%)
		Voltage_CLC	213..620	CDD:279048	139/437 (32%)
		CBS	653..811	CDD:223591	40/184 (22%)
clh-5	NP_495940.1	ClC_3_like	122..614	CDD:239656	162/552 (29%)
		Voltage_CLC	206..594	CDD:279048	138/436 (32%)
		CBS	650..788	CDD:223591	37/160 (23%)
		CBS_pair_EriC_assoc_euk_bac	653..790	CDD:239964	37/159 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810