Protein Alignment ClC-b and ClC-c

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_061502675.1
• Gene: ClC-c / 1276446
• VectorBaseID: AGAMI1_008441
• Length: 927
• Species: Anopheles gambiae
• Alignment Length: 778
• Identity: 216/778 - (27%)
• Similarity: 371/778 - (47%)
• Gaps: 147/778 - (18%)

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRK------DIIR--------WIIFIQIGIITALIAC 163
            ::.::|::       :|..|.|:..|:.::|      |:::        |:..:.:|:.|..:|.
Mosquito   201 DFHTIDWQ-------RDIARDRMRHRYIVKKRQDSFWDLLKGAHDAWSGWVCVLLVGLFTGCVAG 258

  Fly   164 TIDIIIEELSIRKY-----TFLYNSVK----ENVPLSDA--------------SDRD----LLIP 201
            .|||....::..|:     .|..|..:    .|....|:              |.|:    .:|.
Mosquito   259 VIDIGASWMTDLKFGICPQAFWLNREQCCWSSNETSFDSGNCSQWYAWSEIFTSSREGFGAYVIS 323

  Fly   202 YLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVG 266
            |.::::::::.....|::|....|...|||||::|:.|:|..|...:...||.:|::|::.||..
Mosquito   324 YFFYIMWAMLFALLAASLVRMFAPYACGSGIPEIKTILSGFIIRSYLGKWTLIIKSVGIMLSVSA 388

  Fly   267 GLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF-RDDHEKRDFVLGGGAAGVSAAFGAP 330
            ||:.||||||:|..:.:      |...::|     |..: |::.:||:.:....|||||.|||||
Mosquito   389 GLSLGKEGPMVHIASCI------GNILSYL-----FPKYGRNEAKKREILSAAAAAGVSVAFGAP 442

  Fly   331 IGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLK 393
            |||:||||||.:.::....:||:...::|:.|.|       ..:|.|  ..:.||.: :::.|
Mosquito   443 IGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFIL-------RSINPFGNEHSVLFYV-EYNKP-- 497

  Fly   394 FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLA---- 452
            :.:|||..|:.||:.||::...:...|....:|||..   |:|:  |.|.::|..:...:|
Mosquito   498 WIFFELVPFIGLGIIGGIIATLFIKANLWWCRFRKYS---KLGQYPVTEVLIVTFITAVIAYPNP 559

  Fly   453 ------CLMIYFI-NDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHK 510
                  ..:||.: :.|.....||..:..:.|.:.|....:||.               .||.:|
Mosquito   560 YTRMNTSELIYLLFSQCGISNQDPLCDYNRNFTDVNSAIEIAAA---------------GPGVYK 609

  Fly   511 ---ILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAML---TYYVFPQA------ 563
               :|.|||  .:..:::..|||:.|..|:|||:..:||..||::.:.   ..|.:|:.
Mosquito   610 AVWLLILAL--AMKLIMTIFTFGMKVPCGLFIPSLALGAITGRIVGIAMEQLAYNYPKIWIFSGE 672

  Fly   564 -----EFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF- 622
                 :.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||||..
Mosquito   673 CSTGDDCITPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTG-GVRYIVPLMAAAMASKWVGDALG 736

  Fly   623 NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSK--PVICIKIRDS--ANYIYEMLKKCDHNG 683
            .:||||..|.:|..|.|..:...|:..|.|..:..|  ..:.:..:||  .:.|..:||:.:|||
Mosquito   737 RQGIYDAHIALNGYPFLDSKDEFQHTTLAADVMQPKRNETLAVITQDSMTVDDIETLLKETEHNG 801

  Fly   684 FPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSVR 748
            :|||..     :....:.|.:||..|      :|.:.|.|..:...:.|:.    ..|.|.:.|:
Mosquito   802 YPVVVS-----KENQYLVGFVLRRDL------NLALANARRIIDGITGQSL----VIFTSAQPVQ 851

  Fly   749 KLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .|...   .:.|...::.:||.|.....:..:..:||.||||..|| .|..|:.|:||::|.:
Mosquito   852 NLGPS---PLKLKKILDMAPITVTDQTPMETVVDMFRKLGLRQTLV-THNGRLLGVITKKDVL 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	170/598 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	43/164 (26%)
		CBS repeat	657..763	CDD:341367	25/109 (23%)
		CBS repeat	769..812	CDD:341367	16/43 (37%)
ClC-c	XP_061502675.1	None