DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ClC-b and Clcn5

DIOPT Version :9

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:XP_011245744.1 Gene:Clcn5 / 12728 MGIID:99486 Length:851 Species:Mus musculus


Alignment Length:915 Identity:253/915 - (27%)
Similarity:403/915 - (44%) Gaps:220/915 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLL----------- 63
            |.|.|.....|.:|        .|:.:.|.||      .:.:...:.|.:..|:           
Mouse    27 LPGSSEWNPGPYML--------GAMDNRGFHQ------GSFSSFQSSSSDEDLMDIPGTAMDFSM 77

  Fly    64 -DDSQPL---LMGNNSVPPDIPINGSAGSPNRNIN-SSEPIFHLRSRTAAASTPNYESLDYEVCE 123
             ||..||   :.||.|..     .|..||.||.:: ..|||      ....:..::.::|: |.|
Mouse    78 RDDVPPLDREIEGNKSYN-----GGGIGSSNRVMDFLEEPI------PGVGTYDDFNTIDW-VRE 130

  Fly   124 NTLFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRK--- 176
            .:..:|..|: :|.:         .|:......|::.:.||:::..:|..|||....::..|   
Mouse   131 KSRDRDRHRE-ITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGI 194

  Fly   177 ------------------YTF-------LYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFG 216
                              .||       .:||..:.:..:|......::.|..::|::::.....
Mouse   195 CTGGFWFNHEHCCWNSEHVTFEHRDKCPEWNSWAQLIINTDQGAFAYIVNYFMYVLWALLFAFLA 259

  Fly   217 AAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH--- 278
            .::|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|   
Mouse   260 VSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVAC 324

  Fly   279 -AGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAAGVSAAFGAPIGGMLFSLEEA 341
             .|.::.               ..|..:|.:..||..|| ...|||||.||||||||:||||||.
Mouse   325 CCGNILC---------------HCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEV 374

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMI 404
            :.::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :..|||..|::
Mouse   375 SYYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--WHLFELVPFIV 429

  Fly   405 LGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLAC-----------LMI 456
            ||:.|||.||.:  :.|.|...|||... ::||  |:|.::|..:...||.           |:.
Mouse   430 LGIFGGLWGALF--IRTNIAWCRKRKTT-QLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELIS 491

  Fly   457 YFINDCRPLGNDPTNNPVQLFCE-DNEYNA---------------VAALWFQTPEATVRSLFHDP 505
            ...|||..|.:..       .|: :|.:|.               .:|:|               
Mouse   492 ELFNDCGLLDSSK-------LCDYENHFNTSKGGELPDRPAGVGIYSAMW--------------- 534

  Fly   506 PGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VFP 561
                   .|||..::..|::..|||:.:..|:|||:..|||..||||.:    |.||     :|.
Mouse   535 -------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFN 592

  Fly   562 Q-----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDY 621
            .     |:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|.
Mouse   593 SWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSKWVADA 656

  Fly   622 F-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKC 679
            . .|||||..|::|..|.|..:....:|.| |.:::    :.|::.:..:||...  :..::.:.
Mouse   657 LGREGIYDAHIRLNGYPFLEAKEEFAHKTL-AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET 720

  Fly   680 DHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN---KRFWLPETSIQTFRDLYPRF 741
            .::|||||..     |...|:.|.:||..||:      .:||   |:..:..|||..|.:..|..
Mouse   721 TYSGFPVVVS-----RESQRLVGFVLRRDLII------SIENARKKQDGVVSTSIIYFTEHSPPM 774

  Fly   742 PSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIIT 806
            |.....         |:.|...::.||..|.....:..:..|||.||||..|| .|..|:.||||
Mouse   775 PPYTPP---------TLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV-THNGRLLGIIT 829

  Fly   807 RRDFI 811
            ::|.:
Mouse   830 KKDVL 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 CBS_pair_EriC_assoc_euk_bac 674..811 CDD:239964 42/139 (30%)
ClC_6_like 115..639 CDD:239657 178/611 (29%)
Voltage_CLC 213..620 CDD:279048 147/456 (32%)
CBS 653..811 CDD:223591 45/166 (27%)
Clcn5XP_011245744.1 ClC_3_like 177..675 CDD:239656 168/555 (30%)
CBS_pair_voltage-gated_CLC_euk_bac 686..836 CDD:341367 47/171 (27%)
CBS repeat 692..787 CDD:341367 26/114 (23%)
CBS repeat 793..835 CDD:341367 17/43 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000220
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.