Protein Alignment ClC-b and Clcn5

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_011245744.1
• Gene: Clcn5 / 12728
• MGIID: 99486
• Length: 851
• Species: Mus musculus
• Alignment Length: 915
• Identity: 253/915 - (27%)
• Similarity: 403/915 - (44%)
• Gaps: 220/915 - (24%)

  Fly    10 LDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLL----------- 63
            |.|.|.....|.:|        .|:.:.|.||      .:.:...:.|.:..|:
Mouse    27 LPGSSEWNPGPYML--------GAMDNRGFHQ------GSFSSFQSSSSDEDLMDIPGTAMDFSM 77

  Fly    64 -DDSQPL---LMGNNSVPPDIPINGSAGSPNRNIN-SSEPIFHLRSRTAAASTPNYESLDYEVCE 123
             ||..||   :.||.|..     .|..||.||.:: ..|||      ....:..::.::|: |.|
Mouse    78 RDDVPPLDREIEGNKSYN-----GGGIGSSNRVMDFLEEPI------PGVGTYDDFNTIDW-VRE 130

  Fly   124 NTLFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRK--- 176
            .:..:|..|: :|.:         .|:......|::.:.||:::..:|..|||....::..|
Mouse   131 KSRDRDRHRE-ITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGI 194

  Fly   177 ------------------YTF-------LYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFG 216
                              .||       .:||..:.:..:|......::.|..::|::::.....
Mouse   195 CTGGFWFNHEHCCWNSEHVTFEHRDKCPEWNSWAQLIINTDQGAFAYIVNYFMYVLWALLFAFLA 259

  Fly   217 AAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH--- 278
            .::|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|
Mouse   260 VSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVAC 324

  Fly   279 -AGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAAGVSAAFGAPIGGMLFSLEEA 341
             .|.::.               ..|..:|.:..||..|| ...|||||.||||||||:||||||.
Mouse   325 CCGNILC---------------HCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEV 374

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMI 404
            :.::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :..|||..|::
Mouse   375 SYYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--WHLFELVPFIV 429

  Fly   405 LGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLAC-----------LMI 456
            ||:.|||.||.:  :.|.|...|||... ::||  |:|.::|..:...||.           |:.
Mouse   430 LGIFGGLWGALF--IRTNIAWCRKRKTT-QLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELIS 491

  Fly   457 YFINDCRPLGNDPTNNPVQLFCE-DNEYNA---------------VAALWFQTPEATVRSLFHDP 505
            ...|||..|.:..       .|: :|.:|.               .:|:|
Mouse   492 ELFNDCGLLDSSK-------LCDYENHFNTSKGGELPDRPAGVGIYSAMW--------------- 534

  Fly   506 PGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VFP 561
                   .|||..::..|::..|||:.:..|:|||:..|||..||||.:    |.||     :|.
Mouse   535 -------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFN 592

  Fly   562 Q-----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDY 621
            .     |:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|.
Mouse   593 SWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSKWVADA 656

  Fly   622 F-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKC 679
            . .|||||..|::|..|.|..:....:|.| |.:::    :.|::.:..:||...  :..::.:.
Mouse   657 LGREGIYDAHIRLNGYPFLEAKEEFAHKTL-AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET 720

  Fly   680 DHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN---KRFWLPETSIQTFRDLYPRF 741
            .::|||||..     |...|:.|.:||..||:      .:||   |:..:..|||..|.:..|..
Mouse   721 TYSGFPVVVS-----RESQRLVGFVLRRDLII------SIENARKKQDGVVSTSIIYFTEHSPPM 774

  Fly   742 PSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIIT 806
            |.....         |:.|...::.||..|.....:..:..|||.||||..|| .|..|:.||||
Mouse   775 PPYTPP---------TLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV-THNGRLLGIIT 829

  Fly   807 RRDFI 811
            ::|.:
Mouse   830 KKDVL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	178/611 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	46/169 (27%)
		CBS repeat	657..763	CDD:341367	26/110 (24%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
Clcn5	XP_011245744.1	ClC_3_like	177..675	CDD:239656	168/555 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	686..836	CDD:341367	47/171 (27%)
		CBS repeat	692..787	CDD:341367	26/114 (23%)
		CBS repeat	793..835	CDD:341367	17/43 (40%)