back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and Clcn3

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_776299.1	Gene:	Clcn3 / 12725	MGIID:	103555	Length:	866	Species:	Mus musculus

Alignment Length:	869	Identity:	242/869 - (27%)
Similarity:	389/869 - (44%)	Gaps:	191/869 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 TSALARRATLSGNNHLLD----DSQPLLMGNNSVPPDIPI-NGSAGSPNRNINSS--------EP 98
            |||.:....|.|...::|    :...||.|:.:......: ||.      :||||        ||
Mouse    20 TSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGG------SINSSTHLLDLLDEP 78

  Fly    99 IFHLRSRTAAASTPNYESLDY--EVCENTLFQDEQRKRLTER-----FSLRKDII----RWIIFI 152
            |      ....:..::.::|:  |.|::.    |:.:|:..:     :.:.|.:.    .|::..
Mouse    79 I------PGVGTYDDFHTIDWVREKCKDR----ERHRRINSKKKESAWEMTKSLYDAWSGWLVVT 133

  Fly   153 QIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLS----------------DASDRDL--- 198
            ..|:.:..:|..|||..:.::         .:||.:.||                ...:||.
Mouse   134 LTGLASGALAGLIDIAADWMT---------DLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQ 189

  Fly   199 ---------------------LIPYLYWLL-FSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNG 241
                                 .|.|::|.| |:.:.|    ::|....|...|||||::|:.|:|
Mouse   190 WKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAV----SLVKVFAPYACGSGIPEIKTILSG 250

  Fly   242 VKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFR 306
            ..|...:...||.:|.|.::.:|..||:.|||||::|.....      |...::|    ..|...
Mouse   251 FIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCC------GNIFSYL----FPKYST 305

  Fly   307 DDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAY 371
            ::.:||:.:....|||||.||||||||:||||||.:.::....:||:..|::::.|.|
Mouse   306 NEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVL------- 363

  Fly   372 HGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWK 434
            ..:|.|  :...||.: ::.||  :..|||..|::|||.|||.||.:...|....:.||   ..|
Mouse   364 RSINPFGNSRLVLFYV-EYHTP--WYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRK---STK 422

  Fly   435 IGK--VLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCE-DNEYNA 485
            .||  |||.::||.:...:|.           |:.....||.||.:..       .|: .|:.||
Mouse   423 FGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSS-------LCDYRNDMNA 480

  Fly   486 VAALWFQTPEATVRSLFHDPPG---SHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAA 547
                     ...|..:...|.|   ...|..|.|..:...:::..|||:.|..|:|||:..:||.
Mouse   481 ---------SKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAI 536

  Fly   548 WGRLLAM----LTYY-----VFPQ-----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETT 598
            .||::.:    |.||     :|.:     |:.:.||.||::||||.||||.|||:||.||:.|.|
Mouse   537 AGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601

  Fly   599 GVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKA---REILSKP 659
            | ...:..||:.|::::|||||.| .||||:..|::|..|.|..:....:..|.|   |...|.|
Mouse   602 G-GLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDP 665

  Fly   660 VICIKIRD--SANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENK 722
            .:.:..:|  :.:.|..|:.:..:|||||:..     :...|:.|..||..|.:.:..:   ..|
Mouse   666 PLAVLTQDNMTVDDIENMINETSYNGFPVIMS-----KESQRLVGFALRRDLTIAIESA---RKK 722

  Fly   723 RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRAL 787
            :..:..:|...|....|..|: :|.|.|  |:...:|:      ||..|..|..:..:..|||.|
Mouse   723 QEGIVGSSRVCFAQHTPSLPA-ESPRPL--KLRSILDM------SPFTVTDHTPMEIVVDIFRKL 778

  Fly   788 GLRHLLVINHENRIAGIITRRDFI 811
            |||..|| .|...:.||||:::.:
Mouse   779 GLRQCLV-THNGIVLGIITKKNIL 801

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.