Protein Alignment ClC-b and CLCNKB

DIOPT Version :9

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_000076.2
• Gene: CLCNKB / 1188
• HGNCID: 2027
• Length: 687
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 172/721 - (23%)
• Similarity: 309/721 - (42%)
• Gaps: 148/721 - (20%)

  Fly   139 FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYL 203
            |.|.:|   |...:.:|::.||::|.:|:.:|.: :|.:.:||..:.::          .|:.||
Human    44 FRLGED---WYFLMTLGVLMALVSCAMDLAVESV-VRAHQWLYREIGDS----------HLLRYL 94

  Fly   204 YWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG- 267
            .|.::.:..|:|.:.....|.|.:.|||||:||:.|.||.:...:.||....|.:|:..::..|
Human    95 SWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGS 159

  Fly   268 -LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331
             |..||.||.:|...::||.:.:.::||..:.       .:..::.:.::...|.||:..|.||.
Human   160 TLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPF 217

  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFD 395
            .|:|||:|..:|.::....||...|:....|...: |:.::...: |.|.|:... :.|.|  ||
Human   218 SGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRL-LAVFNSEQE-TITSLYKTSFRVDVP--FD 278

  Fly   396 YFELPIFMILGVTGGLLGAAW-------------NSLNTKINKFRKRFIPWKIGKVLEAVVVAMM 447
            ..|:..|:.||...|:||:|:             |..::|:....|     .:...|..:|:|.:
Human   279 LPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSK-----PVYSALATLVLASI 338

  Fly   448 ------GVTLAC-------LMIYFINDCRPLGNDPTNN-----PVQLFCEDNEYNAVAALWFQ-- 492
                  |..||.       |...|.|....|   .|.|     |.:|   |.::     ||::
Human   339 TYPPSAGRFLASRLSMKQHLDSLFDNHSWAL---MTQNSSPPWPEEL---DPQH-----LWWEWY 392

  Fly   493 TPEATVRSLFHDPPGSHKILTLALFTVV-YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLT 556
            .|..|:..            |||.|.|: :::|..|| .:.:..|.|:|..:.|||.|||.....
Human   393 HPRFTIFG------------TLAFFLVMKFWMLILAT-TIPMPAGYFMPIFVYGAAIGRLFGETL 444

  Fly   557 YYVFPQ-------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALIS 614
            .::||:       ...:.||.|||.|||| ..|.:..|||.:::..|.|| :.....|:::|:::
Human   445 SFIFPEGIVAGGITNPIMPGGYALAGAAA-FSGAVTHTISTALLAFEVTG-QIVHALPVLMAVLA 507

  Fly   615 AKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKG-------LKAREILSKPVICIKIRDSANYI 672
            |..:........||..:.|..:|.     ||:..|       ::....::..:..:........:
Human   508 ANAIAQSCQPSFYDGTVIVKKLPY-----LPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEV 567

  Fly   673 YEMLKKCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRD 736
            .:::...|...:|:|:.      :|.:: .||:.|:||:    ::|..|... |.|... |..:|
Human   568 VKVVTSTDVAKYPLVES------TESQILVGIVRRAQLV----QALKAEPPS-WAPGHQ-QCLQD 620

  Fly   737 -LYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENR 800
             |....|:                     .|..::::|..|:.....:|..|.| |.|.:....|
Human   621 ILAAGCPT---------------------EPVTLKLSPETSLHEAHNLFELLNL-HSLFVTSRGR 663

  Fly   801 IAGIIT 806
            ..|.::
Human   664 AVGCVS 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	27/135 (20%)
		ClC_6_like	115..639	CDD:239657	142/543 (26%)
		Voltage_CLC	213..620	CDD:279048	121/450 (27%)
		CBS	653..811	CDD:223591	27/156 (17%)
CLCNKB	NP_000076.2	ClC_1_like	49..534	CDD:239655	141/545 (26%)
		Voltage_CLC	106..513	CDD:279048	120/448 (27%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	27/149 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810