DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and CLCNKA

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_004061.3	Gene:	CLCNKA / 1187	HGNCID:	2026	Length:	687	Species:	Homo sapiens

Alignment Length:	622	Identity:	151/622 - (24%)
Similarity:	273/622 - (43%)	Gaps:	109/622 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYL 203
            |.|.:|   |...:.:|::.||::..::..| ...:|.:.:||..:.::          .|:.||
Human    44 FRLGED---WYFLMTLGVLMALVSYAMNFAI-GCVVRAHQWLYREIGDS----------HLLRYL 94

  Fly   204 YWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG- 267
            .|.::.:..|:|.:.....|.|.:.|||||::|:.|.||.:...:.||....|.:|:..::..|
Human    95 SWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGS 159

  Fly   268 -LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331
             |..||.||.:|...::||.:.:.::||..:.       .:..::.:.::...|.||:..|.||.
Human   160 TLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPF 217

  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFD 395
            .|:|||:|..:|.::....||...|:....|...: |:.::...: |.|.|:... :.|.|  ||
Human   218 SGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRL-LAVFNSEQE-TITSLYKTSFRVDVP--FD 278

  Fly   396 YFELPIFMILGVTGGLLGAAWNSLN------TKINKFRKRFIPWK--IGKVLEAVVVAM------ 446
            ..|:..|:.||...|:|..|:....      .|.|::..:.:...  :...|..:::|.
Human   279 LPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPG 343

  Fly   447 MGVTLAC-------LMIYFINDCRPLGNDPTNN-----PVQLFCEDNEYNAVAALWFQ--TPEAT 497
            :|..||.       |...|.|....|   .|.|     |.:|   |.::     ||::  .|..|
Human   344 VGHFLASRLSMKQHLDSLFDNHSWAL---MTQNSSPPWPEEL---DPQH-----LWWEWYHPRFT 397

  Fly   498 VRSLFHDPPGSHKILTLALFTVV-YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFP 561
            :..            |||.|.|: :::|..|| .:.:..|.|:|..::|||.||||.......||
Human   398 IFG------------TLAFFLVMKFWMLILAT-TIPMPAGYFMPIFILGAAIGRLLGEALAVAFP 449

  Fly   562 Q-------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVG 619
            :       ...:.||.|||.|||| ..|.:..|||.:::..|.|| :.....|:::|:::|..:.
Human   450 EGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTG-QIVHALPVLMAVLAANAIA 512

  Fly   620 DYFNEGIYDTQIQVNHVPMLTWEPLPQYKG-------LKAREILSKPVICIKIRDSANYIYEMLK 677
            .......||..|.|..:|.     ||:..|       ::....::..:..:........:.:::.
Human   513 QSCQPSFYDGTIIVKKLPY-----LPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVT 572

  Fly   678 KCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVIL 713
            ..|...:|:|:.      :|.:: .||:.|:||:..|
Human   573 STDVTEYPLVES------TESQILVGIVQRAQLVQAL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	10/41 (24%)
		ClC_6_like	115..639	CDD:239657	138/538 (26%)
		Voltage_CLC	213..620	CDD:279048	118/445 (27%)
		CBS	653..811	CDD:223591	10/62 (16%)
CLCNKA	NP_004061.3	ClC_1_like	49..534	CDD:239655	137/540 (25%)
		Voltage_CLC	106..513	CDD:279048	117/443 (26%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	10/55 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810