DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-b and CLCNKA

DIOPT Version :10

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_004061.3 Gene:CLCNKA / 1187 HGNCID:2026 Length:687 Species:Homo sapiens


Alignment Length:622 Identity:151/622 - (24%)
Similarity:273/622 - (43%) Gaps:109/622 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYL 203
            |.|.:|   |...:.:|::.||::..::..| ...:|.:.:||..:.::          .|:.||
Human    44 FRLGED---WYFLMTLGVLMALVSYAMNFAI-GCVVRAHQWLYREIGDS----------HLLRYL 94

  Fly   204 YWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG- 267
            .|.::.:..|:|.:.....|.|.:.|||||::|:.|.||.:...:.||....|.:|:..::..| 
Human    95 SWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGS 159

  Fly   268 -LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331
             |..||.||.:|...::||.:.:.::||..:.       .:..::.:.::...|.||:..|.||.
Human   160 TLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPF 217

  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFD 395
            .|:|||:|..:|.::....||...|:....|...: |:.::...: |.|.|:... :.|.|  ||
Human   218 SGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRL-LAVFNSEQE-TITSLYKTSFRVDVP--FD 278

  Fly   396 YFELPIFMILGVTGGLLGAAWNSLN------TKINKFRKRFIPWK--IGKVLEAVVVAM------ 446
            ..|:..|:.||...|:|..|:....      .|.|::..:.:...  :...|..:::|.      
Human   279 LPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPG 343

  Fly   447 MGVTLAC-------LMIYFINDCRPLGNDPTNN-----PVQLFCEDNEYNAVAALWFQ--TPEAT 497
            :|..||.       |...|.|....|   .|.|     |.:|   |.::     ||::  .|..|
Human   344 VGHFLASRLSMKQHLDSLFDNHSWAL---MTQNSSPPWPEEL---DPQH-----LWWEWYHPRFT 397

  Fly   498 VRSLFHDPPGSHKILTLALFTVV-YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFP 561
            :..            |||.|.|: :::|..|| .:.:..|.|:|..::|||.||||.......||
Human   398 IFG------------TLAFFLVMKFWMLILAT-TIPMPAGYFMPIFILGAAIGRLLGEALAVAFP 449

  Fly   562 Q-------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVG 619
            :       ...:.||.|||.|||| ..|.:..|||.:::..|.|| :.....|:::|:::|..:.
Human   450 EGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTG-QIVHALPVLMAVLAANAIA 512

  Fly   620 DYFNEGIYDTQIQVNHVPMLTWEPLPQYKG-------LKAREILSKPVICIKIRDSANYIYEMLK 677
            .......||..|.|..:|.     ||:..|       ::....::..:..:........:.:::.
Human   513 QSCQPSFYDGTIIVKKLPY-----LPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVT 572

  Fly   678 KCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVIL 713
            ..|...:|:|:.      :|.:: .||:.|:||:..|
Human   573 STDVTEYPLVES------TESQILVGIVQRAQLVQAL 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 ClC_6_like 115..639 CDD:239657 138/538 (26%)
CBS_pair_voltage-gated_CLC_euk_bac 652..813 CDD:341367 10/63 (16%)
CBS repeat 657..763 CDD:341367 10/58 (17%)
CBS repeat 769..812 CDD:341367
CLCNKANP_004061.3 ClC_1_like 49..534 CDD:239655 137/540 (25%)
CBS_pair_voltage-gated_CLC_euk_bac 546..676 CDD:341367 10/64 (16%)
CBS repeat 552..627 CDD:341367 10/58 (17%)
CBS repeat 633..675 CDD:341367
Blue background indicates that the domain is not in the aligned region.

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