Protein Alignment ClC-b and CLCN7

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001278.1
• Gene: CLCN7 / 1186
• HGNCID: 2025
• Length: 805
• Species: Homo sapiens
• Alignment Length: 798
• Identity: 379/798 - (47%)
• Similarity: 512/798 - (64%)
• Gaps: 66/798 - (8%)

  Fly    27 AGPTSKAVQDFGLHQREEPSTSALARRATLSG---NNHLLD-DSQPLLMGNNSVPPDIPINGSAG 87
            |||.:         .|:.| .|||.|...:|.   ::.||| |..|    .:..|.:||.|
Human    40 AGPGA---------ARQSP-RSALFRVGHMSSVELDDELLDPDMDP----PHPFPKEIPHN---- 86

  Fly    88 SPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFI 152
                     |.:..|:          ||||||:..||.||.:|:| |:........:|.||:|..
Human    87 ---------EKLLSLK----------YESLDYDNSENQLFLEEER-RINHTAFRTVEIKRWVICA 131

  Fly   153 QIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDR-----DLLIPYLYWLLFSIVP 212
            .|||:|.|:||.|||::|.|:..|    |..:|.|:      |:     .|....|.|...:...
Human   132 LIGILTGLVACFIDIVVENLAGLK----YRVIKGNI------DKFTEKGGLSFSLLLWATLNAAF 186

  Fly   213 VAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMI 277
            |..|:.:|.:|||:.|||||||:|.:|||||||.:||:|||.:|..|||.|||||||.|||||||
Human   187 VLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMI 251

  Fly   278 HAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAA 342
            |:|:|:|||||||:||:..:||:||:.||.|.||||||..|.|||||||||||:||:||||||.|
Human   252 HSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGA 316

  Fly   343 SFWNQNLIWRTLVASIISVFTLNIVLSAYHG-LNDFTFTGLFNLGKFDT-PLKFDYFELPIFMIL 405
            |||||.|.||...||:||.||||.|||.||| :.|.:..||.|.|:||: .:.:...|:|:|:.:
Human   317 SFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAM 381

  Fly   406 GVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPLGNDPT 470
            ||.||:|||.:|:||..:..||.|:|.....:|:|||:||.:..|:|.::||...||:||.....
Human   382 GVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSM 446

  Fly   471 NNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSL 535
            :.|:||||.|.|||::||.:|.|||.:|.|||||||||:..|||.|||:||:.|:|.|:||.||.
Human   447 SYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSA 511

  Fly   536 GVFIPTALVGAAWGRLLAMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGV 600
            |||||:.|:|||||||..:...|:...|.:..||||||:||||.|||::|||:||:||:||.|.
Human   512 GVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATS- 575

  Fly   601 ETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKI 665
            ..::.||:::.|::||.|||.|.||:||..||:..||.|.||.......|.|||::|.||.|::.
Human   576 NVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRR 640

  Fly   666 RDSANYIYEMLK--KCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPE 728
            |:....|.::|.  ..:|||||||:.  .|.....|:.|:||||||||:|...::||.....|.:
Human   641 REKVGVIVDVLSDTASNHNGFPVVEH--ADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQ 703

  Fly   729 --TSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRH 791
              ..::.|||.|||||.|:|:....::...|:|||.||||||..|....|:||:|::||||||||
Human   704 RRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRH 768

  Fly   792 LLVINHENRIAGIITRRD 809
            |:|:::.|::.|::||:|
Human   769 LVVVDNRNQVVGLVTRKD 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	281/530 (53%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	72/162 (44%)
		CBS repeat	657..763	CDD:341367	43/109 (39%)
		CBS repeat	769..812	CDD:341367	20/41 (49%)
CLCN7	NP_001278.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		4/17 (24%)
		ClC_6_like	95..620	CDD:239657	284/536 (53%)
		Selectivity filter part_1. /evidence=ECO:0000250	203..207		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	245..249		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	512..516		3/3 (100%)
		CBS_pair_voltage-gated_CLC_euk_bac	626..790	CDD:341367	72/163 (44%)
		CBS repeat	632..740	CDD:341367	43/109 (39%)
		CBS repeat	746..789	CDD:341367	20/41 (49%)