DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and CLCN6

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	NP_001277.2	Gene:	CLCN6 / 1185	HGNCID:	2024	Length:	869	Species:	Homo sapiens

Alignment Length:	822	Identity:	288/822 - (35%)
Similarity:	437/822 - (53%)	Gaps:	133/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.|..:. |..:.:..:...|.:.::|::...||:.|.|:...:|..:...:..|:
Human    47 DYESLDYDRCINDPYL-EVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKF 110

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .|.:..|...|..||...:...|.|:::..|||:.||||||:||.|||||
Human   111 GVVQTSVEE------CSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGV 169

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.|||::||..|.:||:.||.|||...|||||||:|:||.||:.|.:|.:..|....|..||.
Human   170 KVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRS 234

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.
Human   235 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 299

  Fly   371 YHGLNDFTFTGLFNLGKF---DTPLK---FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|   |:..|   :...:|..|:::||.||||||.:|.||.::.|:|.|
Human   300 FGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMR 364

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCR------PLGND--------PTNNPVQ-L 476
            .:   | |:.:|||:::|:::...:..:....:.:||      .:|||        ..|:.:: .
Human   365 NVHPKP-KLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTF 428

  Fly   477 FCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPT 541
            ||.::.||.:|.|:|...|:.:..|||. .|:...:|||||.|:|::|:|.|:|::|..|:|:|:
Human   429 FCPNDTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPS 492

  Fly   542 ALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFF 605
            .|.|||:|||:| :|..|:  ....::.|.:|||||||.||||:||||||:|||:|:|. |.::.
Human   493 LLCGAAFGRLVANVLKSYI--GLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EITYG 554

  Fly   606 FPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSAN 670
            .|:::.|:.|||.||:||:||||..:.:..||:|.||...:...|:|.:|:...:..:.......
Human   555 LPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQ 619

  Fly   671 YIYEMLKKCDHNGFPVVDDVCGD------------------------------RRSEG------- 698
            .:..:|:...|:.||||.:..|:                              :||:.
Human   620 SLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSS 684

  Fly   699 ---RVC----------------------------------------------------GIILRSQ 708
               .:|                                                    |:|||||
Human   685 ELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQ 749

  Fly   709 LIVILLKSL-YVENK-RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRV 771
            |:.:|::.: |.|:: ....|..|.....:.|||:|.|..:..........||::.:|||||..|
Human   750 LVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTV 814

  Fly   772 NPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFIYK 813
            :|:..|.::|.:||.:|||||.|:|....|.|||||.:..|:
Human   815 SPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYE 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	53/230 (23%)
		ClC_6_like	115..639	CDD:239657	227/550 (41%)
		Voltage_CLC	213..620	CDD:279048	193/433 (45%)
		CBS	653..811	CDD:223591	54/251 (22%)
CLCN6	NP_001277.2	ClC_6_like	49..588	CDD:239657	227/550 (41%)
		Selectivity filter part_1. /evidence=ECO:0000250	156..160		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	198..202		2/3 (67%)
		Selectivity filter part_3. /evidence=ECO:0000250	487..491		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	600..856	CDD:341367	55/255 (22%)
		CBS repeat	606..806	CDD:341367	29/199 (15%)
		CBS repeat	812..855	CDD:341367	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730