Protein Alignment ClC-b and CLCN5

DIOPT Version :9

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_016884746.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 242/848 - (28%)
• Similarity: 382/848 - (45%)
• Gaps: 198/848 - (23%)

  Fly    74 NSVPP-----------DIPINGSA-GSPNRNIN-SSEPIFHLRSRTAAASTPNYESLDYEVCENT 125
            :.|||           |...||.. ||.||.:: ..|||      ....:..::.::|: |.|.:
Human    44 DDVPPLDREVGGIIIEDKSYNGGGIGSSNRIMDFLEEPI------PGVGTYDDFNTIDW-VREKS 101

  Fly   126 LFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRK----- 176
            ..:|..|: :|.:         .|:......|::.:.||:::..:|..|||....::..|
Human   102 RDRDRHRE-ITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICT 165

  Fly   177 ----------------YTF-------LYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAA 218
                            .||       .:||..:.:..:|......::.|..::|::::......:
Human   166 GGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVS 230

  Fly   219 MVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH----A 279
            :|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|    .
Human   231 LVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCC 295

  Fly   280 GAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAAGVSAAFGAPIGGMLFSLEEAAS 343
            |.::.               ..|..:|.:..||..|| ...|||||.||||||||:||||||.:.
Human   296 GNILC---------------HCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSY 345

  Fly   344 FWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILG 406
            ::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :..|||..|::||
Human   346 YFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--WHLFELVPFILLG 400

  Fly   407 VTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLAC-----------LMIYF 458
            :.|||.||.:  :.|.|...|||... ::||  |:|.:||..:...||.           |:...
Human   401 IFGGLWGALF--IRTNIAWCRKRKTT-QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISEL 462

  Fly   459 INDCRPLGNDPTNNPVQLFCE-DNEYN---------------AVAALWFQTPEATVRSLFHDPPG 507
            .|||..|.:..       .|: :|.:|               ..:|:|
Human   463 FNDCGLLDSSK-------LCDYENRFNTSKGGELPDRPAGVGVYSAMW----------------- 503

  Fly   508 SHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VFPQ- 562
                 .|||..::..|::..|||:.:..|:|||:..|||..||||.:    |.||     ||..
Human   504 -----QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSW 563

  Fly   563 ----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF- 622
                |:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|..
Human   564 CSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSKWVADALG 627

  Fly   623 NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKCDH 681
            .|||||..|::|..|.|..:....:|.| |.:::    :.|::.:..:||...  :..::.:..:
Human   628 REGIYDAHIRLNGYPFLEAKEEFAHKTL-AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTY 691

  Fly   682 NGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN---KRFWLPETSIQTFRDLYPRFPS 743
            :|||||..     |...|:.|.:||..||:      .:||   |:..:..|||..|.:..|..|.
Human   692 SGFPVVVS-----RESQRLVGFVLRRDLII------SIENARKKQDGVVSTSIIYFTEHSPPLPP 745

  Fly   744 IKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRR 808
            ....         |:.|...::.||..|.....:..:..|||.||||..|| .|..|:.||||::
Human   746 YTPP---------TLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV-THNGRLLGIITKK 800

  Fly   809 DFI 811
            |.:
Human   801 DVL 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	42/139 (30%)
		ClC_6_like	115..639	CDD:239657	180/611 (29%)
		Voltage_CLC	213..620	CDD:279048	149/456 (33%)
		CBS	653..811	CDD:223591	45/166 (27%)
CLCN5	XP_016884746.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810