DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and clcn6

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_002937575.2	Gene:	clcn6 / 100496474	XenbaseID:	XB-GENE-990272	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	824	Identity:	288/824 - (34%)
Similarity:	434/824 - (52%)	Gaps:	136/824 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.:..:. |..:.:..:.:.|.:.:|||:...||:.|.|:...:|..::..|..||
Frog    41 DYESLDYDRCISDPYL-EVLESINYKRAWRYEAVRWIMVFAIGVCTGLVGLFVDFFVQLFSRFKY 104

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .::|..|...|..||...:...|.|.:...|:|:.||||||::|.|||||
Frog   105 RVVQGSVEE------CTERGCLALSLLELLGFNLTFTFIATLFVLIQPVAAGSGIPEIKCYLNGV 163

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.:||::||..||:||:..|.|||..||||||||:||||.||:.|.:|.:|.|....|..||.
Frog   164 KVPGVVRLRTLVCKALGVLFGVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISFQKIRFDFPYFRS 228

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.
Frog   229 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 293

  Fly   371 YHGLNDFTFTGLFNLGKFDTP------LKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|..|      ..:...:|..|:|:|||||||||.:|.||.::.|:|.:
Frog   294 FSSWGSFQLPGLLNFGEFKCPDADKKCHLWTVVDLAFFIIMGVTGGLLGATFNCLNKRLAKYRMK 358

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPL---------------GNDPTNNPVQ- 475
            .:   | |:.:|.|:::::::...:..:....:.:||.|               .::..|:.::
Frog   359 NVHPKP-KLVRVFESLLISLVTTVIVFVASMVLGECRELSPSNWSNTSLTVQVSSSEEVNSSIKT 422

  Fly   476 LFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIP 540
            .||.:|.||.:|.|:|...|:.:..|||. .|:...:||:.|..:|::|||.|:|::|..|:|:|
Frog   423 FFCPNNTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTLSFFCCMYFLLSCWTYGISVPSGLFVP 486

  Fly   541 TALVGAAWGRLLAML--TYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETS 603
            :.|.|||:|||:|.|  :|..|   ..::.|.:|||||||.||||:||||||:|||:|:|. |.|
Frog   487 SLLCGAAYGRLVANLLKSYLGF---SHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EIS 547

  Fly   604 FFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDS 668
            :..|::|.|:.|||.||:||:||||..:::..||:|.||...:...|:|.:|:...:..:.....
Frog   548 YGLPIMITLMVAKWTGDFFNKGIYDIHVELRGVPLLEWETEEEMDKLRASDIMEPNLTYVYPHTR 612

  Fly   669 ANYIYEMLKKCDHNGFPVVDDVCGD------------------------------RRSEG----- 698
            ...:..:|:...|:.||||.:..|:                              :||:.
Frog   613 IQSLVSILRTTAHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKASILTRAGEQRKRSQSMKSYP 677

  Fly   699 -----RVC----------------------------------------------------GIILR 706
                 .:|                                                    |:|||
Frog   678 SSELRNMCDEHIATEEPVEKEDMLQQMLERRYTPYPNLYPDQSPSEEWTMEERFRPLTFHGLILR 742

  Fly   707 SQLIVILLKSL-YVENKRFW-LPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPI 769
            |||:.:|::.: |.||:... .|..|.....:.|||:|.|..|..........||::.:||..|.
Frog   743 SQLVTLLVRGVCYAENQSSANQPRLSHAEMCEDYPRYPDIHDVNLTLLNPRMIVDVTPYMNVCPF 807

  Fly   770 RVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFIYK 813
            .|:|:..|.::|.:||.:|||||.|:|....|.|||||.:..::
Frog   808 NVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTHE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	53/230 (23%)
		ClC_6_like	115..639	CDD:239657	228/552 (41%)
		Voltage_CLC	213..620	CDD:279048	191/435 (44%)
		CBS	653..811	CDD:223591	54/251 (22%)
clcn6	XP_002937575.2	ClC_6_like	43..583	CDD:239657	228/552 (41%)
		CBS_pair_voltage-gated_CLC_euk_bac	595..851	CDD:341367	55/255 (22%)
		CBS repeat	601..801	CDD:341367	31/199 (16%)
		CBS repeat	807..850	CDD:341367	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1363
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		oto102889
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1393
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980