Protein Alignment ClC-b and clcn2

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_002935192.2
• Gene: clcn2 / 100488889
• XenbaseID: XB-GENE-494657
• Length: 882
• Species: Xenopus tropicalis
• Alignment Length: 795
• Identity: 191/795 - (24%)
• Similarity: 329/795 - (41%)
• Gaps: 192/795 - (24%)

  Fly   148 WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVP 212
            ||..|.:|::.||::..:|..| .:.::.:.::|..:..||          .:.||.|:.:.:|.
 Frog    85 WIFLILLGLLMALVSWAMDFTI-AICLQAHKWMYGGLDNNV----------FLQYLAWVTYPVVL 138

  Fly   213 VAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMI 277
            :.|.|.....:.|...|||||::|:.|.||.:...:.:||...|.||:..::..||..|||||.:
 Frog   139 ITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGLPLGKEGPFV 203

  Fly   278 HAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKR-DFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            |..::.||.:|        |...:|....::..:. :.:....|.||...|.|||||:|||:|..
 Frog   204 HVASMCAALLS--------KLMSLFGGIYENESRNIEMLAAACAVGVGCCFAAPIGGVLFSIEVT 260

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFDYFELPIFMIL 405
            ::|:.....||...|:..|.|...::  |....::.|.|.||... :.|.|  ||..|||.|.::
 Frog   261 STFFAVRNYWRGFFAATFSAFIFRVL--AVWIKDEETITALFKTSFRLDFP--FDLQELPAFAVI 321

  Fly   406 GVTGGLLGAAWNSLNTKINKFRK------RFIPWKIGKVLEAVVVAMMGVTLA------------ 452
            |:..|..||.:..||.||.:|.:      ||:..|  ::|...:|.::..||.
 Frog   322 GIASGFGGALFVYLNRKIVEFMRKQKTINRFLMKK--RLLFPALVTLLVATLTFPPGFGQFMAGQ 384

  Fly   453 -----CLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKIL 512
                 .|:..|         |......|...||..|..::::| :.|:|.|            .:
 Frog   385 LTQKETLVTLF---------DNYTWAQQGISEDFAYRGISSVW-KHPKANV------------FV 427

  Fly   513 TLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLH---------P 568
            ||.:|.::.:.:|.....:.|..|.|:|..::|||:|||:.......||..  :|         |
 Frog   428 TLVVFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDG--IHTDGSTYRIVP 490

  Fly   569 GKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQV 633
            |.||::|||| |.|.:..|:|.:||:.|.|| :.|...|::||:|.|..|.......:||:.|::
 Frog   491 GGYAVVGAAA-LSGAVTHTVSTAVIVFELTG-QISHILPVMIAVILANAVAQSLQPSLYDSIIRI 553

  Fly   634 N---HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRR 695
            .   ::|.|.|....:| .::..:|:.:.:..:.:......:.|:|..|......:|:      .
 Frog   554 KKLPYLPELGWGHQEKY-NVRVEDIMLRNIPFVTLNSKYRDLQELLTNCHLKCLALVE------T 611

  Fly   696 SEGRV-CGIILRSQLIVIL---------LKSL---------YVENK-RFWL-------------- 726
            :|..: .|.|.||||:.:|         |:.|         ..||. ||.:
 Frog   612 AESMILLGSIDRSQLLSLLRFQLSSKRRLQQLRERESSGKKQTENSVRFQITTEESTFSPPQGET 676

  Fly   727 ----------------------PETSIQTFRDLY--------------PRFPSIKSVRKLDEKIN 755
                                  .:.|:...:.::              |..||.|:..:|..:..
 Frog   677 RKPLKPALKHTLSSLTESPADDSDNSVTALKSIFCAKDFSEPLEVVKDPASPSKKNKSRLKHRHR 741

  Fly   756 YTVDLSMF--------------------------MNPSPIRVNPHDSVPRIFQIFRALGLRHLLV 794
            ...||...                          ::|:|.::....|:.:...:|..||:.|..|
 Frog   742 LGEDLDEIDTMTQSQILEWEEIQLEEPINLNNCKIDPAPFQLVERTSLHKAHTVFSLLGMDHAYV 806

  Fly   795 INHENRIAGIITRRD 809
            .: ..|:.|::|.|:
 Frog   807 TS-IGRLIGMVTLRE 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	149/527 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	39/254 (15%)
		CBS repeat	657..763	CDD:341367	26/175 (15%)
		CBS repeat	769..812	CDD:341367	10/41 (24%)
clcn2	XP_002935192.2	ClC_1_like	84..561	CDD:239655	148/526 (28%)
		COG3448	<550..637	CDD:442671	18/93 (19%)
		CBS_pair_SF	<774..824	CDD:449531	12/48 (25%)
		CBS repeat	781..823	CDD:341367	10/41 (24%)