DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-b and XB22062446

DIOPT Version :9

Sequence 1:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster
Sequence 2:	XP_002934155.3	Gene:	XB22062446 / 100488828	XenbaseID:	XB-GENE-22062447	Length:	818	Species:	Xenopus tropicalis

Alignment Length:	839	Identity:	244/839 - (29%)
Similarity:	395/839 - (47%)	Gaps:	136/839 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SGNNHLLDDSQPLLMGNNSVPPDI--PINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDY 119
            ||...:.:||..::...||  .||  ..:|      .:.:.|..|.|  .:.....||  |||:|
Frog     8 SGYKAIDEDSHLIIQNENS--EDILDEFDG------MDQHMSNGICH--KKKEFQETP--ESLNY 60

  Fly   120 EVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSV 184
            ....:     |..|...|...|..|..||.:...||:...:....:..||:.|...|:..:.|.:
Frog    61 LPSHS-----EAYKTWLEEKPLGSDWDRWFMMGLIGVFVGIFGFLMHQIIDFLFEMKWELVENYI 120

  Fly   185 KENVPLSDASDRDLLIPYLYWLL-----FSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKI 244
            :.|         |.|..   |::     |:::.|:.|  :|.:..|..:.||:|:|..||||..|
Frog   121 QNN---------DFLTT---WMVIAGIGFAMMLVSSG--LVVFFCPSGSPSGLPEVIGYLNGASI 171

  Fly   245 PRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDH 309
            ..|..|:|..........:|..||..|.|.||||.||.:..|:||.||.|...:...|..||:..
Frog   172 RHIFNIRTFFGSFFSCALAVSAGLFCGPEAPMIHVGAAIGCGLSQFKSDTLRINLPFFTRFRNSA 236

  Fly   310 EKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGL 374
            :||.|:..|.|||:::.|.||:||:||.|||.||||:..|.|:|....:::.||..::.|::.|
Frog   237 DKRQFITAGAAAGIASVFRAPVGGLLFVLEEVASFWDVKLAWQTFFCCLVATFTTEVLSSSFVG- 300

  Fly   375 NDFTFTGLFNLGKFDTPLKF---DYFELPIF-----MILGVTGGLLGAAWNSLNTKINKFRKRF- 430
              |.:.|.|...|.:..:.|   |...:.:.     :|||:.||||||.:..:|.:|||.|.:.
Frog   301 --FEYEGYFGFFKAEQRIIFWVKDLLNISVLAVIPTIILGIIGGLLGALFVFINVRINKLRMKIF 363

  Fly   431 --IPWK----IGKVLEAVVVAMMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCED--------- 480
              :|.|    :.|:|:.:::.::.:|:...:.||.: |.|   :||.:.||...|.
Frog   364 TSVPHKFLRQLTKLLDTLLILVVTITVTVYIPYFFS-CSP---NPTASQVQNASEHKPHGEHAAW 424

  Fly   481 --NEYNAVAALWFQTPEATVRS--------------------LFHDPPGSHK---ILTLALFTVV 520
              :|||......:..|..::.:                    |.:. .|||:   :..|.:..:.
Frog   425 DVSEYNCPPGSSWVAPNGSIMANHSINQAAVLLVKNGKQGTMLLYQ-RGSHEKFGLPALLMALIF 488

  Fly   521 YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVF-----PQAEFLHPGKYALIGAAANL 580
            |:.:||.|.|.....|:.:|....||.:|||:.::...:|     ....::.||.:|:||:||..
Frog   489 YFTISCWTAGTAAGTGLVVPMVYTGALFGRLVGLIMVAMFGVQTDEYGAWIDPGLFAVIGSAAYF 553

  Fly   581 GGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLP 645
            |||.|:||||:||::|.|....|... ::||::..|.||||||..::.:.:.:..:|.|...|..
Frog   554 GGVTRLTISLTVIMVEITNDVQSILL-IMIAVLVGKTVGDYFNNSLFSSLLHLKCIPYLKAVPNV 617

  Fly   646 QYKGLK-------AREILSKPVIC--IKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVC 701
            .:...|       ||:::..   |  |.::::...:.|:|....|||||||......:  |....
Frog   618 VHGKKKVNLELFTARDVMQS---CTTIHLQENVFLLAELLSTTSHNGFPVVFSPAPGQ--EEVFL 677

  Fly   702 GIILRSQLIVILLKSLYVENKRFWLPE----TSIQTFRDL-YPRFPSIKSVRKLDEKINYTVD-- 759
            |.|.|.:|.::|..|     :.|..||    :|:..:::: ..:.|....:.:|..|  |:.|
Frog   678 GTITRLELYMLLSNS-----RVFQTPENNQCSSVLKYQEVTVEKLPDEAQINRLLNK--YSADPQ 735

  Fly   760 -------LSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
                   |..::|.|.:.|..|.|:.|.:.:||.||||||.|::.:||..|||||:|.|
Frog   736 YQQLFINLEPYINKSAVSVQAHFSLQRTYVVFRTLGLRHLTVVDLQNRAVGIITRKDLI 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	49/150 (33%)
		ClC_6_like	115..639	CDD:239657	173/582 (30%)
		Voltage_CLC	213..620	CDD:279048	144/460 (31%)
		CBS	653..811	CDD:223591	52/173 (30%)
XB22062446	XP_002934155.3	Voltage_gated_ClC	56..618	CDD:295552	175/589 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	630..793	CDD:341367	52/174 (30%)
		CBS repeat	636..746	CDD:341367	28/121 (23%)
		CBS repeat	752..793	CDD:341367	20/40 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53783
OrthoDB	1	1.010	-	-		D311775at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930