Protein Alignment ClC-b and clcnkb

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_031755485.1
• Gene: clcnkb / 100487225
• XenbaseID: XB-GENE-6049695
• Length: 828
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 177/789 - (22%)
• Similarity: 309/789 - (39%)
• Gaps: 195/789 - (24%)

  Fly   140 SLRKDIIR----WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLI 200
            :||:.::|    ||....:||..|.|:..:|:.|.:|.           :.|:.:.||.||...:
 Frog    68 ALRRLLVRLGEDWIFLFLLGISMATISFGLDVTIAKLQ-----------RANLWVYDALDRYRYL 121

  Fly   201 PYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVV 265
            .|..|:|:.::.:...|.|..||.|..||||||::|..|.||.:.....::|...|.|||..::.
 Frog   122 QYFSWVLYHVLLMITSAGMAKYISPQAAGSGIPEIKVTLRGVVLAEFFTLRTFIAKLIGVTCTLA 186

  Fly   266 GG--LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFG 328
            .|  :..||.||.:|...::|..:  |:...     ::..|..:...|.:.::.|.|.||:..|.
 Frog   187 AGSTIFLGKVGPFVHMATILATQL--GRLMV-----KLVGAKENPSRKYEMLVAGAAVGVACCFV 244

  Fly   329 APIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGK------ 387
            ||:||:|||:|..|:.:.....||...|:..:...             |....:.|..|
 Frog   245 APVGGVLFSVEATATHFAVRNYWRGFFAATCAALM-------------FRLLAVINREKETVAIL 296

  Fly   388 FDTPLKFDY-FELPIFM---ILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVL---EAVVVA 445
            |.|..:.:: |:||.::   ||||..|.|...:..|:.....|.:.. | :|..:|   ..|..|
 Frog   297 FSTNWRVEFPFDLPEYLSYAILGVVCGCLCCVYLFLHRTTLLFLQNH-P-RISTLLRNNRMVYAA 359

  Fly   446 MMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDN-------------EYNAVAALWFQTPEAT 497
            .:...||.:..       |.|........:|..:::             |.:..|.:..|.|..:
 Frog   360 FVAWVLASITF-------PHGFGQYLGGTRLTMKEHLETFFNNITWGIEELSLGANISGQPPNPS 417

  Fly   498 VRSLF----HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYY 558
            ..:.|    |....:.:|||  .|.|:.:.:......:.:..|.|:|..:.||..|||...:...
 Frog   418 YSNNFLQWTHPNMSTLEILT--CFVVLKFFMLLFANTMIIPAGYFLPVFVYGAGLGRLYGEIMAK 480

  Fly   559 VFPQAEF-------LHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAK 616
            :||....       :.|..|||.||||..|.|.: |:|.::::.|.:| :.|...|::||::.|.
 Frog   481 IFPNGIVSEGIPIKITPAGYALAGAAAYSGAVTQ-TLSTALLVFELSG-QMSHILPVLIAVLIAN 543

  Fly   617 WVGDYFNEGIYDTQIQVNHVPMLTWEPLPQ-------------------YKGLKAREILSKPVIC 662
            .:...:....:|..:.:..:|.|....:.|                   .||.:.|:|.|
 Frog   544 AISQNYQSSFFDLIVIIKKLPYLPKLAMGQNSAHDICAEDFMVTDLQYLVKGFRYRDIRS----- 603

  Fly   663 IKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVILLKSLYVENK-RFW 725
                        :||..:...||.||.      .|.:| .|...|..|..:|.:.|..|.: :|.
 Frog   604 ------------LLKSSELKQFPFVDS------EESKVLLGCFSRKSLAKLLAEQLSTERRIQFM 650

  Fly   726 LPETSIQTFRDLYPRFPSIKS-------VRKLDE------------------------------- 752
            |.:|.     ..:|..||.::       :.|::|
 Frog   651 LDKTG-----GKFPITPSGENGTDEKTDLHKIEECEYSDTTYSAQETVVYESEEKQKTRTESRRR 710

  Fly   753 -------------------KINYTVDLSMF-MNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINH 797
                               ::|..|.|.:. ::|:|.|:...:::.:.:.:|..|||| ...:..
 Frog   711 RSAKFKSHYLKMVEEWECRQLNEEVPLELLTIDPTPYRLLEKETLYQCYDLFNLLGLR-TAYVTR 774

  Fly   798 ENRIAGIIT 806
            ..|:.|:::
 Frog   775 IGRLVGVVS 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	135/541 (25%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	38/215 (18%)
		CBS repeat	657..763	CDD:341367	26/164 (16%)
		CBS repeat	769..812	CDD:341367	8/38 (21%)
clcnkb	XP_031755485.1	ClC_1_like	79..567	CDD:239655	132/531 (25%)
		CBS_pair_SF	581..790	CDD:449531	40/232 (17%)
		CBS repeat	586..677	CDD:341358	25/118 (21%)
		CBS repeat	747..789	CDD:341358	8/38 (21%)