Protein Alignment ClC-b and clcn3

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_012812850.1
• Gene: clcn3 / 100216107
• XenbaseID: XB-GENE-950794
• Length: 867
• Species: Xenopus tropicalis
• Alignment Length: 876
• Identity: 245/876 - (27%)
• Similarity: 398/876 - (45%)
• Gaps: 205/876 - (23%)

  Fly    47 TSALARRATLSG-----NNHLLDDSQPLLMGNNSVPPDIPI-NGSAGSPNRNINSS--------E 97
            |||.:....|.|     :.|.|:|.. ||.|:.||.....: ||.|      |||:        |
 Frog    20 TSASSDEELLDGAGGMMDFHTLEDDN-LLDGDASVGTHYTMTNGGA------INSTTHLLDLLDE 77

  Fly    98 PIFHLRSRTAAASTPNYESLDY--EVCENTLFQDEQRKRLTER-----FSLRKDII----RWIIF 151
            ||      ....:..::.::|:  |.|::.    |:.:|:..:     :.|.|.:.    .|::.
 Frog    78 PI------PGVGTYDDFHTIDWVREKCKDR----ERHRRINSKKKESAWELAKSLYDAWSGWLVV 132

  Fly   152 IQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLS-----------DASD---------- 195
            ...|:.:..:|..|||..:.::         .:||.:.::           |:.:
 Frog   133 TLTGLASGALAGFIDIAADWMA---------DLKEGICMTAFWFNHEQCCWDSKEATFEERDKCP 188

  Fly   196 -----RDLL--------------IPYLYWLL-FSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLN 240
                 .||:              |.|::|.| |:.:.|    .:|....|...|||||::|:.|:
 Frog   189 QWQTWADLIIGQAEGPGSYIMNYIMYIFWALSFAFLAV----CLVKVFAPYACGSGIPEIKTILS 249

  Fly   241 GVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF 305
            |..|...:...||.:|.:.::.:|..||:.|||||::|.....      |...::|    ..|..
 Frog   250 GFIIRGYLGKWTLMIKTVTLVLAVASGLSLGKEGPLVHVACCC------GNIFSYL----FPKYS 304

  Fly   306 RDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA 370
            .::.:||:.:....|||||.||||||||:||||||.:.::....:||:..|::::.|.|
 Frog   305 TNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVL------ 363

  Fly   371 YHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRK--RFI 431
             ..:|.|  :...||.: ::.||  :..|||..|::|||.|||.||.:...|....:.||  ||
 Frog   364 -RSINPFGNSRLVLFYV-EYHTP--WYLFELIPFILLGVFGGLWGAFFIRANIAWCRRRKTTRF- 423

  Fly   432 PWKIGK--VLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCE-DNE 482
                ||  |||.::||.:...:|.           |:.....||.||.:..       .|: .|:
 Frog   424 ----GKYPVLEVMLVAAITAVIAFPNPYTRFNTSQLIKELFTDCGPLESSS-------LCDYKND 477

  Fly   483 YNAVAALWFQTPEATVRSLFHDPPGS---HKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALV 544
            .|:         ...|..:...|.|:   ..|..|.|..|...:::..|||:.|..|:|||:..:
 Frog   478 MNS---------SKIVDDIPDRPAGTGVYSAIWQLCLALVFKIIMTVFTFGIKVPSGLFIPSMAI 533

  Fly   545 GAAWGRLLAM----LTYY-----VFPQ-----AEFLHPGKYALIGAAANLGGVLRMTISLSVILM 595
            ||..||::.:    |.||     :|.:     |:.:.||.||::||||.||||.|||:||.||:.
 Frog   534 GAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVF 598

  Fly   596 ETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL--- 656
            |.|| ...:..||:.|::::|||||.| .||||:..|::|..|.|..:....:..| ||:::
 Frog   599 ELTG-GLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-ARDVMRPR 661

  Fly   657 -SKPVICIKIRD--SANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLY 718
             |.|.:.:..:|  :.:.:..::....:|||||:..     :...|:.|..||..|      :|.
 Frog   662 RSDPPLAVLTQDNMTVDDVESLINDTSYNGFPVIMS-----KESQRLVGFALRRDL------TLA 715

  Fly   719 VEN---KRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRI 780
            :||   |:..:..:|...|....|..|: :|.|.|  |:...:|:      ||..|.....:..:
 Frog   716 IENARKKQEGIVGSSRVCFAQHTPSLPA-ESPRPL--KLRSILDM------SPFTVTDQTPMEIV 771

  Fly   781 FQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            ..:||.||||..|| .|...:.||||:::.:
 Frog   772 VDLFRKLGLRQCLV-THNGTVLGIITKKNIL 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	177/611 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	44/169 (26%)
		CBS repeat	657..763	CDD:341367	26/110 (24%)
		CBS repeat	769..812	CDD:341367	14/43 (33%)
clcn3	XP_012812850.1	ClC_3_like	136..642	CDD:239656	169/560 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	653..801	CDD:341367	45/169 (27%)
		CBS repeat	659..754	CDD:341367	25/108 (23%)
		CBS repeat	760..801	CDD:341367	14/41 (34%)