Protein Alignment ClC-b and clcn2a

DIOPT Version :9

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001315638.1
• Gene: clcn2a / 100150892
• ZFINID: ZDB-GENE-070705-19
• Length: 979
• Species: Danio rerio
• Alignment Length: 860
• Identity: 211/860 - (24%)
• Similarity: 342/860 - (39%)
• Gaps: 227/860 - (26%)

  Fly   105 RTAAASTPNYESLDYE--------VCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALI 161
            ||.:......|.|:||        ||.:..     :|.|..|  :.:|   ||..|.:|::.||:
Zfish    45 RTTSVRGQAPELLEYEKDPCAKCQVCTSRC-----KKFLISR--VGED---WIFLILLGLLMALV 99

  Fly   162 ACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPI 226
            :..:|..| ....:...::|..:..|          :|:.||.|:.:.:|.:.|.|.....:.|.
Zfish   100 SWAMDYTI-AFCQQAQKWMYRGLHSN----------MLLQYLAWVTYPVVLITFSAGFTQILAPQ 153

  Fly   227 TAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGK 291
            ..|||||::|:.|.||.:...:..||...|.||:..::..|:..|||||.:|..::.||.:|:
Zfish   154 AVGSGIPEMKTILRGVVLKEYLTFKTFVAKVIGLTCALGSGMPLGKEGPFVHVASLCAALLSK-- 216

  Fly   292 STTFLKDF------RIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLI 350
               |:..|      ..|:..:::....:.:....|.||...|.|||||:|||:|..::|:.....
Zfish   217 ---FMALFGGIYMEEPFEGNKNELRNTEMLSAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNY 278

  Fly   351 WRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAA 415
            ||...|:..|.|...::  |....::.|.|.||.. :|.....||..|||.|.:||:..|..||.
Zfish   279 WRGFFAATFSAFIFRVL--AVWNKDEETITALFKT-RFRLDFPFDLQELPAFAVLGIASGFGGAL 340

  Fly   416 WNSLN----------TKINKF--RKRFIPWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPLG-- 466
            :..||          ..||||  :||.       |..||      |||....:.|     |.|
Zfish   341 YVYLNRIIVESMRKQKTINKFLLKKRL-------VYPAV------VTLLISTLTF-----PPGFG 387

  Fly   467 ----NDPTNNP--VQLF----------CEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLA 515
                ...|.:.  |.||          .|:.||::.....::.|:.:|            .:||.
Zfish   388 QFMAGQLTQHESLVALFDNLTWYKQGVAEEFEYSSHVPQAWKHPQVSV------------FITLL 440

  Fly   516 LFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLH---------PGKY 571
            ||.|:.:.:|.....:.|..|.|:|..|:|||:|||:.......||..  :|         ||.|
Zfish   441 LFIVMKFWMSAVATTMPVPCGAFMPVFLIGAAFGRLVGESMAAFFPDG--IHADSTVYPIVPGGY 503

  Fly   572 ALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHV 636
            |::|||| |.|.:..|:|.:||:.|.|| :.|...|::||:|.|..|.......:||:.|::..:
Zfish   504 AVVGAAA-LSGAVTHTVSTAVIVFELTG-QISHILPVMIAVILANAVAQSLQPSLYDSIIRIQKL 566

  Fly   637 PMLTWEPLPQYK-GLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRV 700
            |.|......|.| .::..:|:.:.|..|.:..|...:.|.|.........:|:.     :....:
Zfish   567 PYLPELGWGQEKYNIRVEDIMVRDVRYITLSSSYRDLQEALVTGQLKTLALVES-----KESMIL 626

  Fly   701 CGIILRSQLIVILLKSLYVENKRFWLPE------TSIQTFRDLYP-------RF----------- 741
            .|.|.||||..:|.:.|....:..:|.|      |.:.||....|       ||
Zfish   627 LGSIERSQLQSLLSQQLGRPRRLEYLRERAQDNGTHVPTFTPDSPPKAGRGVRFLISTEESSYSP 691

  Fly   742 ----------PSIKSV------------------------------------------------- 747
                      .::|:|
Zfish   692 TLTNSQIPLKSALKTVSAISNTDSLNSSPNLSCGEPVKELVESNAGPMAPKRSRRPKRVKIPMAD 756

  Fly   748 ------------------RKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLV 794
                              ::|||.:|:.   :..::|:|.::....|:.:...||..|||.|..|
Zfish   757 TADVEDDMSTAEIAEWEEQQLDEAVNFN---NCKIDPAPFQLVERTSLHKTHTIFSLLGLDHAYV 818

  Fly   795 INHENRIAGIITRRD 809
            .: ..|:.|:::.::
Zfish   819 TS-TGRLVGVVSLKE 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	37/237 (16%)
		ClC_6_like	115..639	CDD:239657	165/576 (29%)
		Voltage_CLC	213..620	CDD:279048	136/451 (30%)
		CBS	653..811	CDD:223591	41/258 (16%)
clcn2a	NP_001315638.1	ClC_1_like	85..571	CDD:239655	157/541 (29%)
		Voltage_CLC	138..550	CDD:279048	137/453 (30%)
		CBS_pair_EriC_assoc_euk_bac	<788..836	CDD:239964	12/46 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810