Protein Alignment ClC-b and clcn4

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001120070.1
• Gene: clcn4 / 100145074
• XenbaseID: XB-GENE-949931
• Length: 760
• Species: Xenopus tropicalis
• Alignment Length: 836
• Identity: 236/836 - (28%)
• Similarity: 369/836 - (44%)
• Gaps: 205/836 - (24%)

  Fly    82 INGSAGSPNRNINS--SEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRKD 144
            ||||:     |:..  .|||      ....:..::.::|: :.|.:...|..||..::......:
 Frog     7 INGSS-----NLMDFLDEPI------PDVGTYEDFHTIDW-LREKSRDTDRHRKITSKSKESIWE 59

  Fly   145 IIR--------WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPL----------- 190
            .|:        |::.:.||::...:|..||:.::.::         .:||.:.|
 Frog    60 FIKGLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMT---------DLKEGICLNAFWYSHEQCC 115

  Fly   191 --SDAS---DRD----------LLIP--------------YLYWLL-FSIVPVAFGAAMVTYIEP 225
              ||.:   |||          |:|.              |:.|.| |:.:.|    ::|....|
 Frog   116 WTSDETTFEDRDKCPQWQKWSELMIDQSEGASAYILNYFLYIMWALSFAFLAV----SLVRVFAP 176

  Fly   226 ITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQG 290
            ...|||||::|:.|:|..|...:...||.:|.:.::..|..||:.|||||.:|.........|.
 Frog   177 YACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPSVHVACCCGNLFSS- 240

  Fly   291 KSTTFLKDFRIFKAFRDDHEKRDFVLGGGAA-GVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTL 354
                      :|..:..:..||..||...|| |||.||||||||:||||||.:.::....:||:.
 Frog   241 ----------LFSKYSKNEGKRREVLSAAAAVGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSF 295

  Fly   355 VASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWN 417
            .|::::.|||       ..:|.|  :...||.: ::.||  :...||..|::|||.|||    |.
 Frog   296 FAALVAAFTL-------RSINPFGNSRLVLFYV-EYHTP--WYMAELFPFILLGVFGGL----WG 346

  Fly   418 SLNTKINKFRKRFIPW-------KIGK--VLEAVVVAMMGVTLAC-----------LMIYFINDC 462
            :|..:.|      |.|       |:||  |||.:||..:...||.           |:....|||
 Frog   347 TLFIRCN------IAWCRRRKTTKLGKYPVLEVIVVTAITALLAYPNPYTRRSTSELISELFNDC 405

  Fly   463 RPLG--------NDPT-NNPVQLFCEDNEYNA--VAALWFQTPEATVRSLFHDPPGSHKILTLAL 516
            ..|.        |||. ..||. ...|.:..|  ..|:|                      .|||
 Frog   406 GALESSQLCDYINDPNMTRPVD-DIPDRQAGAGVYTAMW----------------------QLAL 447

  Fly   517 FTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VF-----PQAEFLH 567
            ..:...:::..|||:.:..|:|||:..|||..||::.:    |.|:     :|     |.|:.:.
 Frog   448 ALIFKIIITIFTFGMKIPSGLFIPSIAVGAIAGRIVGVGVEQLAYHHHDWIIFRNWCRPGADCVT 512

  Fly   568 PGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQI 631
            ||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|.| .||||:..|
 Frog   513 PGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAVTSKWVADAFGKEGIYEAHI 576

  Fly   632 QVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKCDHNGFPVVDDV 690
            .:|..|.|..:....::.| |.:::    .:|.:.:..:||...  :..::|..|:||||||..
 Frog   577 HLNGYPFLDVKDEFTHRTL-AMDVMRPRRGEPSLSVLTQDSMTVEDVETLIKDTDYNGFPVVVS- 639

  Fly   691 CGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKIN 755
                |...|:.|...|.:||:.:..:   ..::..:...||..|.:..|..|:         ...
 Frog   640 ----RDSERLIGFAQRRELIIAIKNA---RQRQDGVVSNSIIYFTEDPPELPA---------NSP 688

  Fly   756 YTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            :.:.|...:|.||..|..|..:..:..|||.||||..|| ....|:.||||::|.:
 Frog   689 HPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLV-TRSGRLLGIITKKDVL 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	182/621 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	44/166 (27%)
		CBS repeat	657..763	CDD:341367	23/107 (21%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
clcn4	NP_001120070.1	ClC_3_like	78..584	CDD:239656	174/573 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	595..745	CDD:341367	45/168 (27%)
		CBS repeat	601..696	CDD:341367	23/111 (21%)
		CBS repeat	702..744	CDD:341367	17/43 (40%)