DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and DIT2

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	524	Identity:	119/524 - (22%)
Similarity:	196/524 - (37%)	Gaps:	134/524 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PKPIPILGNTWRLMPI---IGQYTISDVAKISSLLHDRYGRIVRFGG-----LIGRPDLL--FIY 132
            ||.||.:......:|:   |.|..:.|:....|:  ::||.:..|.|     |:.|.:.|  ...
Yeast    30 PKNIPTIPFYVVFLPVIFPIDQTELYDLYIRESM--EKYGAVKFFFGSRWNILVSRSEYLAQIFK 92

  Fly   133 DADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLS 197
            |.|...|....:           .:.|.::..  :.||  .|:..:|..||.:|:.|...
Yeast    93 DEDTFAKSGNQK-----------KIPYSALAA--YTGD--NVISAYGAVWRNYRNAVTNG----- 137

  Fly   198 TIRRYLQPLE--VITEDFLVRC----ENLLDENQELPEDFDNEIHKWSLECIGRVALDTRLGCL- 255
                 ||..:  .|.::..:.|    ..||:....:|  ......:.:|:.|.:|||....|.|
Yeast   138 -----LQHFDDAPIFKNAKILCTLIKNRLLEGQTSIP--MGPLSQRMALDNISQVALGFDFGALT 195

  Fly   256 -ESNLKPDSEPQQIIDAAKYALRNVATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQ-SA 318
             |.|    :..:.:|...|....   ...|..|:....|.|...:..|::..|..:.:|.:| ..
Yeast   196 HEKN----AFHEHLIRIKKQIFH---PFFLTFPFLDVLPIPSRKKAFKDVVSFRELLVKRVQDEL 253

  Fly   319 TERLKTQDPSLRAGEPSLVEKVILSQKDE----KIATIMALDLILVGIDTISMAVCSMLYQLATR 379
            ....|.:..:..|.:      :|.:..:|    |..|...:.:::.|.:...:...|.||.||..
Yeast   254 VNNYKFEQTTFAASD------LIRAHNNEIIDYKQLTDNIVIILVAGHENPQLLFNSSLYLLAKY 312

  Fly   380 PVD-QQKVHEELKRLLPDPNTPLTIPLLDQMHHLKGFIKEVFRMY---STVIGNGRT----LMED 436
            ..: |:|:.:|:.. :.||.....:|||:      .|:.||.|||   ||:|....|    |..:
Yeast   313 SNEWQEKLRKEVNG-ITDPKGLADLPLLN------AFLFEVVRMYPPLSTIINRCTTKTCKLGAE 370

  Fly   437 SVICGYQVPKGVQAVFPTIVTG-NMEEYVTDAATFRPERW-------------------LKPQHG 481
            .||     ||||...:....|. :.:.:.|.|..|:||||                   :...||
Yeast   371 IVI-----PKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHG 430

  Fly   482 GTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL----EYNHKPLDYAVTFMYAP 542
                            |.|.|||.:.|..||:|.||::|:.::.    |:..|         ..|
Yeast   431 ----------------GRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEK---------LTP 470

  Fly   543 DGPL 546
            .|||
Yeast   471 AGPL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	114/506 (23%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	110/487 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100