DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and cyp11a1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_694485.2	Gene:	cyp11a1 / 80374	ZFINID:	ZDB-GENE-010306-1	Length:	509	Species:	Danio rerio

Alignment Length:	499	Identity:	123/499 - (24%)
Similarity:	229/499 - (45%)	Gaps:	53/499 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QNAL--PYNQIPGPKPIPILGNTWR--LMPIIGQYT----ISDVAKISSLLHD--RYGRIVRFGG 121
            ||:.  |:|:|||         .||  |:.::. :|    :.:|.:|  ::|:  .:|.|.|  .
Zfish    34 QNSTVQPFNKIPG---------RWRNSLLSVLA-FTKMGGLRNVHRI--MVHNFKTFGPIYR--E 84

  Fly   122 LIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFR 186
            .:|..|.::|...::....:::||..|.|.::.:...|     :|:.....||:...|:.|:..|
Zfish    85 KVGIYDSVYIIKPEDGAILFKAEGHHPNRINVDAWTAY-----RDYRNQKYGVLLKEGKAWKTDR 144

  Fly   187 SRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDEN--QELPEDFDNEIHKWSLECIGRVALD 249
            ..:.|.:|.......::..||.:.:||:.|....::.:  ::...|..:::.|:|||.:..|...
Zfish   145 MILNKELLLPKLQGTFVPLLEEVGQDFVARVNKQIERSGQKQWTTDLTHDLFKFSLESVSAVLYG 209

  Fly   250 TRLGCLESNLKPDSEPQQIIDAAKYALRNVA-TLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMK 313
            .|||.|..|:.|  |.|..||......:..: .|.|.....|...:.:|..:|:..:.......:
Zfish   210 ERLGLLLDNIDP--EFQHFIDCVSVMFKTTSPMLYLPPGLLRSIGSNIWKNHVEAWDGIFNQADR 272

  Fly   314 YIQSATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMA--LDLILVGIDTISMAVCSMLYQL 376
            |||:..::.| ::|......|.:: .::|.|....|..|.|  .:|:..|:|:::..:...||:|
Zfish   273 YIQNIFKQWK-ENPEGNGKYPGVL-AILLMQDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYEL 335

  Fly   377 ATRPVDQQKVHEELK--RLLPDPNTPLTIPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVI 439
            |.:|..|.::..|:.  |:....:   .:.::..:..||..:||..|::...:...|.:.||:||
Zfish   336 ARQPDLQDELRAEISAARIAFKGD---MVQMVKMIPLLKAALKETLRLHPVAMSLPRFITEDTVI 397

  Fly   440 CGYQVPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLG 504
            ..|.:|.|..........|...::......:.|.||:.       .|...|.||.:|:|.|.|||
Zfish   398 QNYHIPAGTLVQLGVYAMGRDHQFFPKPEQYCPSRWIS-------SKRQYFKSLGFGFGPRQCLG 455

  Fly   505 RRFADLEMQILLAKLLRNYKLEYNHKPLDYAVTF--MYAPDGPL 546
            ||.|:.||||.|..:|.|:::| ..|.::....|  :..|:.|:
Zfish   456 RRIAETEMQIFLIHMLENFRIE-KQKQIEVRSKFELLLMPEKPI 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	114/468 (24%)
cyp11a1	NP_694485.2	p450	66..502	CDD:278495	112/457 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820