DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp301a1 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	567	Identity:	149/567 - (26%)
Similarity:	237/567 - (41%)	Gaps:	88/567 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QC-VPRISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPIL 84
            || |..|| .||..:.|..|   |...|||..........:|.:|....|....|     .||..
Zfish   173 QCSVCEIS-IGSMFSSCAGS---VCARPHLCVRASVCVRPLHQSSRSAGAARLFQ-----EIPDT 228

  Fly    85 G-NTWRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRP--------DLLFIYDADEIEKC 140
            | |.|  |.::..:.....:::...:.:.:.|:    |.|.|.        :::...|..|:
Zfish   229 GSNGW--MNLLRFWRDGRFSRMHKHMEESFRRL----GPIYREHLGSQSSVNIMLPMDTGEL--- 284

  Fly   141 YRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQP 205
            :||||..|.|.::.....::...|..     .||...:|..||..|..:.:.|:..|::.|:|..
Zfish   285 FRSEGLHPRRMTLQPWATHRETRRHS-----KGVFLKNGTEWRADRLLLNREVMVSSSVHRFLPL 344

  Fly   206 LEVITEDFLVRCENLLDENQ----------ELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLK 260
            |:.:.:||   |.:|....|          .|..|...::.:::||....|....|:|...|  .
Zfish   345 LDEVAQDF---CRSLRRRVQADGFEKAGQHTLTLDPSPDLFRFALEASCHVLYGERIGLFSS--C 404

  Fly   261 PDSEPQQIIDAAKYALRNVATLELKAPYWRYFP--------TPLWTRYVKNMNFFVGVCMKYIQS 317
            |..|.::.|.|.:   |.:||    .|...|.|        ..|||.:....:.......:.||.
Zfish   405 PSDESERFISAVE---RMLAT----TPPLLYLPPRLLLRLRASLWTTHATAWDDIFSHAEQRIQR 462

  Fly   318 ATERLKTQDPSLR--AGEPSLVEKVI-LSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATR 379
            :.:||:.: ||..  ...|.::.|:: ..|...::......:|:..|:||.::.:...|::||..
Zfish   463 SYQRLQAR-PSAAPDCSFPGVLGKLMEAGQLSLELIRANITELMAGGVDTTAVPLQFALFELARN 526

  Fly   380 PVDQQKVHEEL----KRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVI 439
            |..|:.|..::    ::...||...|. .||      |||.|||..|:|...|...|..:.|.|:
Zfish   527 PDVQECVRAQVLSSWQQASGDPLKALQGAPL------LKGTIKETLRLYPVGITVQRYPVRDIVL 585

  Fly   440 CGYQVPKG--VQ-AVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARM 501
            ..|.||.|  || .::|   .|...|..:....|.|.||......|:.|   .|.||.:|:|:|.
Zfish   586 QNYHVPAGTLVQVCLYP---LGRSAEVFSRPECFDPSRWSADADAGSAG---GFRSLAFGFGSRQ 644

  Fly   502 CLGRRFADLEMQILLAKLLRNYKLEYNH-KPLDYAVTFMYAPDGPLR 547
            |:|||.|:.|||:||..:||.:||..:. :.|....|.:..|:.|.|
Zfish   645 CVGRRIAENEMQLLLMHILRTFKLTVSSTEELSTKYTLILQPECPPR 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	127/492 (26%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820