DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and cyp11a2

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio

Alignment Length:	540	Identity:	129/540 - (23%)
Similarity:	233/540 - (43%)	Gaps:	88/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VATCPHLAD---SEEASAPRI---HSTSEWQNALPYNQIPGPKPIPILGNTWR--LMPIIGQYTI 99
            |::..||..   :....||.|   .||     ..|:|:|||         .||  |..:.....:
Zfish    14 VSSLKHLLQVIVTRSGRAPAIGLQDST-----VRPFNEIPG---------QWRNSLKSVFAFAKM 64

  Fly   100 SDVAKISSLL---HDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKS 161
            ..:..|..::   .:.:|.|.|  ..:|..:.:.|...::....:::||..|.|.::.:...|:.
Zfish    65 GGLRNIHRIMVHNFNTFGPIYR--EKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYRD 127

  Fly   162 VVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDEN-- 224
            ...:.:     ||:...||.|:..|..:.|.|:.......::..|:.:.:||:.|....::.:
Zfish   128 YRNRKY-----GVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNKKIERSGQ 187

  Fly   225 QELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVA-TLELKAPY 288
            .:...|..:|:.|::||.:..|....|||.|...:.|||  |:.||......:..: .|.|....
Zfish   188 NQWTTDLSHELFKFALESVSAVLYGERLGLLLDYIDPDS--QRFIDCITLMFKTTSPMLYLPPGL 250

  Fly   289 WRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVI----LSQKDEKI 349
            .|...:.:|..:|:..:.......:.||:...:|: ::|........::..::    ||.:|.|.
Zfish   251 LRPIRSKIWRNHVEAWDGIFNQADRCIQNIYRQLR-KNPEGNGKYTGVLASLLMLDKLSIEDIKA 314

  Fly   350 ATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELK--RLLPDPNTPLTIPLLDQMHHL 412
            :   ..:|:..|:||.::.:...||:||..|..|:::..|:.  |:....:   .:.:|..:..:
Zfish   315 S---VTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAEISAARIASKGD---MVQMLKMIPLV 373

  Fly   413 KGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGV------------QAVFPTIVTGNMEEYVT 465
            ||.:||..|::...:...|.:.||.||..|.:|.|.            ..|||     |.|:|:
Zfish   374 KGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQLGLYAMGRDHQVFP-----NPEQYL- 432

  Fly   466 DAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYNHK 530
                  |.||:..|:       |.|.||.:|:|.|.|||||.|:.|||:.|..:|.|:::|   |
Zfish   433 ------PSRWVNSQN-------HYFKSLSFGFGPRQCLGRRIAETEMQLFLIHMLENFRIE---K 481

  Fly   531 PLDYAVTFMY----APDGPL 546
            .....|..|:    .|:.|:
Zfish   482 QRQMEVKSMFELILLPEKPI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	113/479 (24%)
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	113/471 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820