DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and cyp27a7

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_002663445.1	Gene:	cyp27a7 / 402831	ZFINID:	ZDB-GENE-081104-519	Length:	524	Species:	Danio rerio

Alignment Length:	513	Identity:	135/513 - (26%)
Similarity:	221/513 - (43%)	Gaps:	56/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PRISGAGSRRAQCRESSTGVATCP-HLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNT 87
            |..:..|.|||....::..|:... |.....||..|.                     |.|....
Zfish    22 PTAAATGFRRAAGNAAAASVSVQDGHRKLKTEADLPE---------------------IKIFTML 65

  Fly    88 WRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPS 152
            :||  :...| :|.:.::.......||.:.:..  :|....:.:...|.:|:..|.:...|.|..
Zfish    66 YRL--LFKGY-LSRMHELQLYEKQLYGPLYKIN--VGNFQSVALNSVDLLEELLRKDEKFPSRGD 125

  Fly   153 MPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRC 217
            |....:|     :|..|...|.....||.|.:.|:.:.|.:|......:|...:..:..||:.|.
Zfish   126 MTLWTEY-----RDMKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRI 185

  Fly   218 ENL--LDENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVA 280
            ..|  :....:|..:..||::::|||.|..:..:||:||||..:  .:|.|..|:    ::..:.
Zfish   186 YYLREMSPTGDLVSNLTNELYRFSLEGISSILFETRIGCLEKEI--PAETQHFIN----SIAQML 244

  Fly   281 TLELKA---PYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERL-KTQDPSLR-AGE--PSLVE 338
            |..:..   |.|.....|.|.||:...:.......|.|....|.| |..|.:.. |||  ..|:.
Zfish   245 TYSMPVVFMPNWTRNYLPFWQRYIGGWDGIFKFAGKMIDMKMEALQKRVDANQEVAGEYLTYLLS 309

  Fly   339 KVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTI 403
            ...:|.||   ......:|:|.|:||.|..:...||.|:..|..|..:::|:..:|.|...| |.
Zfish   310 NGKMSSKD---VYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRIP-TA 370

  Fly   404 PLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVIC-GYQVPKGVQAVFPTIVTGNMEEYVTDA 467
            ..::.|.:||..|||..|:|..|..|.|.:.|:.|:. |:..||..............|:...:.
Zfish   371 QEVNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLCHYAISRDEKVFPEP 435

  Fly   468 ATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL 525
            ..|:|||||:  .|.|  :.:||.|:|:|:|.|.|:|||.|:|||.:.||:|::.:::
Zfish   436 QKFKPERWLR--DGRT--RPNPFGSIPFGFGVRGCVGRRIAELEMYLALARLIKLFEI 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	125/460 (27%)
cyp27a7	XP_002663445.1	p450	68..507	CDD:278495	122/446 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.870