DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and shd

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	130/522 - (24%)
Similarity:	232/522 - (44%)	Gaps:	49/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQYTISDVAKISSLLHDRYG 114
            |:..:..||:......|       .|||||.||.||..|..:....:|.::.:.::.:.|:.:||
  Fly    44 AELIQPEAPKRRRRGIW-------DIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYG 101

  Fly   115 RIVRFGGLIGRPD---LLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVG 176
            .||    |...|.   ::.:|:.|::||..:.....||||....:|.|:. .|.|.:..: |:|.
  Fly   102 DIV----LEVMPSNVPIVHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYRQ-SRPDRYASV-GIVN 160

  Fly   177 VHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQELPEDFDNEIHKWSLE 241
            ..|..|:..||.:...:.....::.:|..|..:.:||:.......|.:..:..:|:...:...||
  Fly   161 EQGPMWQRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDPDTLVVPNFEELANLMGLE 225

  Fly   242 CIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATLELKAPY----WRYFPTPLWTRYVK 302
            .:..:.|..|:|.|..:.|   :||:|...|. |::.:...:..:.|    |:||||..:..:.:
  Fly   226 AVCTLMLGRRMGFLAIDTK---QPQKISQLAA-AVKQLFISQRDSYYGLGLWKYFPTKTYRDFAR 286

  Fly   303 NMNFFVGVCMKYIQSATERLK-------TQDPSLRAGEPSLVEKVILSQKDEKIATIMALDLILV 360
            ..:....|..:.|....|.||       .:...||:...:::|...|..:|:|.|.|   |.|..
  Fly   287 AEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDKKSAII---DFIAA 348

  Fly   361 GIDTISMAVCSMLYQLATRPVDQQKVHEEL-----KRLLPDPNTPLTIPLLDQMHHLKGFIKEVF 420
            ||:|::..:..:|..:...|....::..|.     ..:|.|..|..|        :.|..|:|.:
  Fly   349 GIETLANTLLFVLSSVTGDPGAMPRILSEFCEYRDTNILQDALTNAT--------YTKACIQESY 405

  Fly   421 RMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLKP-QHGGTP 484
            |:..|.....|.|.||..:.||.:..|...:...::..:.:.....|..|.||||:.| ....|.
  Fly   406 RLRPTAFCLARILEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTV 470

  Fly   485 GKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYNHKPLDYAVTFMYAPDGPLRFK 549
            ...:....:|:|.|.|.|.|:||.::|:.:||||::..:.:.: .|||:....|:.||..||..:
  Fly   471 NVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSF-VKPLETEFEFLLAPKTPLSLR 534

  Fly   550 MT 551
            ::
  Fly   535 LS 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	117/473 (25%)
shd	NP_001261843.1	p450	63..528	CDD:299894	122/486 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28158
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.930