DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	109/519 - (21%)
Similarity:	197/519 - (37%)	Gaps:	136/519 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 IPGPKPIPILGNTWRLMPIIGQYTISDV--AKISSLLHDRYGRIVRFGGLIG-RPDLLFIYDADE 136
            :.|.:|:...||    |..:|:    |:  ..|:..::.::..:.|:.|... ....|||.|.:.
  Fly    31 VAGERPVYFRGN----MSGLGR----DLHWTDINLRIYRKFRGVERYCGYFTFMTKSLFIMDLEL 87

  Fly   137 IEKCYRSEGPTPFRPSMPSLVKYKSVVRKDF--FGD------------LGGVVGVHGEPWREFRS 187
            |                      :.::.:||  |.|            .|.::.:.|..||..|.
  Fly    88 I----------------------RDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQ 130

  Fly   188 RVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQELPE---------DFDNEIHKWSLECI 243
            .:.:  :..|...:::.|             |:::..::|.:         :..:...:::.:.|
  Fly   131 NLTQ--VFTSGKMKFMFP-------------NMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVI 180

  Fly   244 GRVALDTRLGCLESNLKPDSEPQ---------------QIIDAAKYALRNVATLELKAPYWRYFP 293
            |..|..     ||.|...|.|.|               .::.|..:|...:|. :|:   :|.|.
  Fly   181 GSCAFG-----LECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELAR-KLR---FRLFR 236

  Fly   294 TPLWTRYVKNMNFFVGVCMKYIQ-SATERLKTQD---PSLRAGEPSLVEKVILSQKDEKIATIMA 354
            ..:       ..||:....:.:. ...|.:...|   ..:..||..:.:.:..    |:||. .|
  Fly   237 PEV-------SEFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSF----EQIAA-QA 289

  Fly   355 LDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTIPLLDQMHHLKGFIKEV 419
            |...|.|.||.|..:...||:||..|..|:::..|:..:|...|..||...:.:|.:|...:.|.
  Fly   290 LVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAET 354

  Fly   420 FRMYSTVIGNGRTLMEDSVICGYQVPK-------GVQAVFPTIVTGNMEEYVTDAATFRPERWLK 477
            .|.|..:....|...::     ||:|.       |.:.:.|.....:..|...|...|.|.|:
  Fly   355 LRKYPILPHLLRRSTKE-----YQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRF-- 412

  Fly   478 PQHGGTPGKL---HPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYNHK---PLDYA 535
                 .|.::   ||||.||:|.|.|.|:|.||..|::::.|..|||::|...:.|   ||.::
  Fly   413 -----EPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	106/508 (21%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	109/517 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910