DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and CYP27C1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001354431.1	Gene:	CYP27C1 / 339761	HGNCID:	33480	Length:	537	Species:	Homo sapiens

Alignment Length:	555	Identity:	143/555 - (25%)
Similarity:	254/555 - (45%)	Gaps:	75/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRL 90
            :.|...||.|     ...|..|..|.:|:..|.|..|......|      .||:.:       ..
Human    22 LGGGAPRRPQ-----PAGARLPAGARAEDKGAGRPGSPPGGGRA------EGPRSL-------AA 68

  Fly    91 MPIIGQYTISDVAKI-----SSLLHD-------RYGRIVRFGGLIGRPDLLFIYDADEIEKCYRS 143
            ||  |..|::::|:.     .|.:|:       .||:|  |....|...::.|.|.|.:.:..|:
Human    69 MP--GPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKI--FKSHFGPQFVVSIADRDMVAQVLRA 129

  Fly   144 EGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEV 208
            ||..|.|.:|.|..:|     :|..|...|::...||.|.:.||.:::.:|:...:..|...:..
Human   130 EGAAPQRANMESWREY-----RDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVNQ 189

  Fly   209 ITEDFLVRCENLLD--ENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQ---QI 268
            :..|.:.|...|..  |:.|...:.::...|:|:|.:..:..::||||||:::     ||   :.
Human   190 VIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSI-----PQLTVEY 249

  Fly   269 IDAAK--YALRNVATLELKAPYW--RYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSL 329
            |:|.:  :::...:......|.|  .:.|.| |..:.::.:........::.:....::.|....
Human   250 IEALELMFSMFKTSMYAGAIPRWLRPFIPKP-WREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRG 313

  Fly   330 RAGEPSLVEKVILSQK---DEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELK 391
            |.....|:..:.|||.   .|..|.:  .:::|.|:||.|..:...:|.||..|..||.|:.|:.
Human   314 RRVSGGLLTYLFLSQALTLQEIYANV--TEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIV 376

  Fly   392 RLLPDPNTPLT-----IPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAV 451
            :.|.:.:.|..     :||      ::..:||..|::..:.||||...||.||.||.:|||.|..
Human   377 KNLGERHVPTAADVPKVPL------VRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLA 435

  Fly   452 FPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILL 516
            .....|...:|....|..|||||||:.   |...::..|.|:|:|:|.|.|:|||.|:||:.:::
Human   436 LCHYATSYQDENFPRAKEFRPERWLRK---GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVV 497

  Fly   517 AKLLRNYKLEYNHKP-LDYAVTF-MYAPDGPLRFK 549
            .:||::::::.:.:. ..:|.|. :..|.||:..:
Human   498 IQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	126/482 (26%)
CYP27C1	NP_001354431.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820