DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_849178.2	Gene:	Cyp27a1 / 301517	RGDID:	727915	Length:	533	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	143/534 - (26%)
Similarity:	237/534 - (44%)	Gaps:	81/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RISGAGSRRAQCRESSTGVATCP-HLADSEEASA-------PRIHSTSEWQNALPYNQIPGPKPI 81
            |:.|.|    .|.:.:...|..| .|.|.|....       ||:.|.:|         :|||
  Rat    17 RVMGHG----LCPQGARAKAAIPAALRDHESTEGPGTGQDRPRLRSLAE---------LPGP--- 65

  Fly    82 PILGNTWRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGP 146
               |....|..:..:..:..:.::.:|...:||.:  :....|....:.:..|..:|:..|.||.
  Rat    66 ---GTLRFLFQLFLRGYVLHLHELQALNKAKYGPM--WTTTFGTRTNVNLASAPLLEQVMRQEGK 125

  Fly   147 TPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITE 211
            .|.|.||....::     :|..|...|:....|:.|...|..:.:.:|:.:....|...|..:..
  Rat   126 YPIRDSMEQWKEH-----RDHKGLSYGIFITQGQQWYHLRHSLNQRMLKPAEAALYTDALNEVIS 185

  Fly   212 DFLVRCENLLDEN---QELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAK 273
            ||:.|.:.:..|:   .::| |..:.::..:||.|..:..:.|:||||.::     |:   |.|.
  Rat   186 DFIARLDQVRTESASGDQVP-DVAHLLYHLALEAICYILFEKRVGCLEPSI-----PE---DTAT 241

  Fly   274 YALRNVATLELKAPYWRYFP------TPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAG 332
            : :|:|..:...:.|..:.|      .|.|.||:.|.:.......|.|....:.::.|   |:|.
  Rat   242 F-IRSVGLMFKNSVYVTFLPKWSRPLLPFWKRYMNNWDNIFSFGEKMIHQKVQEIEAQ---LQAA 302

  Fly   333 EPS----------LVEKVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVH 387
            .|.          |:.|.:||.: |.:.|..  :|||.|:||.|..:...||.|:..|..|:.:|
  Rat   303 GPDGVQVSGYLHFLLTKELLSPQ-ETVGTFP--ELILAGVDTTSNTLTWALYHLSKNPEIQEALH 364

  Fly   388 EELKRLLPDPNTPLT-----IPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLME-DSVICGYQVPK 446
            :|:..::|....|..     :||      ||..|||..|:|..|..|.|.:.| ::.|.|:..||
  Rat   365 KEVTGVVPFGKVPQNKDFAHMPL------LKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPK 423

  Fly   447 GVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLE 511
            ..|.|....|.........:..:|:|.|||:.:.....|..|||.|:|:|||.|.|||||.|:||
  Rat   424 NTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDDNSGIQHPFGSVPFGYGVRSCLGRRIAELE 488

  Fly   512 MQILLAKLLRNYKL 525
            ||:||::|::.|::
  Rat   489 MQLLLSRLIQKYEV 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	130/475 (27%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58		5/19 (26%)
		cytochrome_P450	91..527	CDD:425388	124/441 (28%)
		Sterol-binding. /evidence=ECO:0000255	386..400		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870