Protein Alignment Cyp301a1 and Cyp11a1

DIOPT Version :10

• Sequence 1: NP_610796.1
• Gene: Cyp301a1 / 36378
• FlyBaseID: FBgn0033753
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_058982.1
• Gene: Cyp11a1 / 29680
• RGDID: 69325
• Length: 526
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 131/544 - (24%)
• Similarity: 222/544 - (40%)
• Gaps: 84/544 - (15%)

  Fly    36 CRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQYTIS 100
            |:...:.|...|.||....|.   |.||:..::   :|:||.|.     .|.|
  Rat    16 CQPFLSPVWQGPGLATGNGAG---ISSTNSPRS---FNEIPSPG-----DNGW------------ 57

  Fly   101 DVAKISSLLH------------------DRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPT 147
                 .:|.|                  .:||.|.|  ..:|..:.::|.|..:....:..|||.
  Rat    58 -----INLYHFLRENGTHRIHYHHMQNFQKYGPIYR--EKLGNMESVYILDPKDAATLFSCEGPN 115

  Fly   148 PFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITED 212
            |.|..:|..|.|....::..     ||:....:.||:.|..:.:.|:...:|:.::..||.:.:|
  Rat   116 PERYLVPPWVAYHQYYQRPI-----GVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQD 175

  Fly   213 FL-VRCENLLDENQ-ELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYA 275
            |: |....:..:|. :...|..:::.:::.|.|..|....|||.||..:.|:|  |:.|||. |.
  Rat   176 FIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPES--QRFIDAV-YQ 237

  Fly   276 L--RNVATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLK-TQDPSLRAGEPSLV 337
            :  .:|..|.:....:|.|.|..|..:....:.......:|.|:....|: .:|.|...|    |
  Rat   238 MFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPG----V 298

  Fly   338 EKVILSQKDEKIATIMA--LDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEEL---KRLLPDP 397
            ...:|.........|.|  .:::..|:||.||.:...||::|.....|:.:..|:   :|.....
  Rat   299 LYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGD 363

  Fly   398 NTPLT--IPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNM 460
            ...:.  :||      ||..|||..|::...:...|.::.|.|:..|::|........:...|..
  Rat   364 MAKMVQLVPL------LKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRE 422

  Fly   461 EEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL 525
            ..:..:...|.|.|||:.....|    | |..|.:|:|.|.|||||.|:|||.|.|..:|.|:::
  Rat   423 SSFFPNPNKFDPTRWLEKSQNTT----H-FRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRI 482

  Fly   526 EYNH-KPLDYAVTFMYAPDGPLRF 548
            |... :.:......:..|:.|:.|
  Rat   483 EVQSIRDVGTKFNLILMPEKPIFF 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	CYP24A1-like	110..547	CDD:410677	114/467 (24%)
Cyp11a1	NP_058982.1	cytochrome_P450	80..505	CDD:477761	113/449 (25%)