DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	145/539 - (26%)
Similarity:	244/539 - (45%)	Gaps:	79/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQY 97
            :|....:...|..||.:.|.|..:.               ..:|||...|:||:   |:.|..:.
  Rat    31 KASASRAPKEVPLCPLMTDGETRNV---------------TSLPGPTNWPLLGS---LLEIFWKG 77

  Fly    98 TISDVAKISSLLHDRYGRIVR-----FGGL-IGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSL 156
            .:.......:..|.:||:|.|     |..: :|.|.||        |..||:|...|.|..:...
  Rat    78 GLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL--------EALYRTESAHPQRLEIKPW 134

  Fly   157 VKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLL 221
            ..|     :|...:..|::.:.|:.|:..||..||.:::...|.:..:.:..:..|||.|.:.|.
  Rat   135 KAY-----RDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELC 194

  Fly   222 DENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATL---- 282
            ||...:| |..:|::|||.|.|..|..:.|.|.|:.  :.:.|....|.|.|..:.....:
  Rat   195 DERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQK--ETEEEALTFITAIKTMMSTFGKMMVTP 256

  Fly   283 -----ELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVIL 342
                 .|....|:.. |..|....|:    |..|   |.:..:|. :|.|    |...|.:  |.
  Rat   257 VELHKRLNTKVWQAH-TLAWDTIFKS----VKPC---IDNRLQRY-SQQP----GADFLCD--IY 306

  Fly   343 SQ----KDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTI 403
            .|    |.|..|.:  .:|.|..::|.:.::..:||.|:..|..|:::.:|::.:|||..||...
  Rat   307 QQDHLSKKELYAAV--TELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAE 369

  Fly   404 PLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAA 468
            .|.: |.:||..:||..|:..:|....|||.:.:|:..|.:|||......|.|.|:.|:...|:.
  Rat   370 DLRN-MPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSH 433

  Fly   469 TFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL-EYNHKPL 532
            .|||||||:.:.     |::|||.||:|.|.|||:|||.|:|::.:.|..:::.|.: ..:::|:
  Rat   434 KFRPERWLQKEK-----KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV 493

  Fly   533 DYAVTFMYAP--DGPLRFK 549
            :.....:..|  :.|:.|:
  Rat   494 EMLHLGILVPSRELPIAFR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	135/473 (29%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	129/456 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870