DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and CYP27A1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_000775.1	Gene:	CYP27A1 / 1593	HGNCID:	2605	Length:	531	Species:	Homo sapiens

Alignment Length:	537	Identity:	138/537 - (25%)
Similarity:	228/537 - (42%)	Gaps:	75/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQ---IPGPKP------- 80
            ::..|..|.:......|...|||.|.: :|:.|.         |||.::   .||..|
Human     1 MAALGCARLRWALRGAGRGLCPHGARA-KAAIPA---------ALPSDKATGAPGAGPGVRRRQR 55

  Fly    81 ----IPILGNTWRLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCY 141
                ||.||.......:..|.....:.::..|...:||.:  :...:|....:.:..|..:|:..
Human    56 SLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPM--WMSYLGPQMHVNLASAPLLEQVM 118

  Fly   142 RSEGPTPFRPSMPSLVKYKSVVRKDFFGDLG-GVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQP 205
            |.||..|.|..|....:::..      .||. |.....|..|.:.|..:.:.:|:.:....|...
Human   119 RQEGKYPVRNDMELWKEHRDQ------HDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDA 177

  Fly   206 LEVITEDFLVRCENLLDE----NQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQ 266
            ...:.:||:.|.:.|..|    ||  ..|.....:.::||.|..:..:.|:|||:.::..|:..
Human   178 FNEVIDDFMTRLDQLRAESASGNQ--VSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVT- 239

  Fly   267 QIIDAAKYALRNVATLELKAPYWRYFP------TPLWTRYVKNMNFFVGVCMKYIQSATERLKTQ 325
                    .:|::..:...:.|..:.|      .|.|.||:...|.......|.|.   |:|:..
Human   240 --------FVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLID---EKLEDM 293

  Fly   326 DPSLRAGEPSLVE-------KVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQ 383
            :..|:|..|..::       .:...|...:.|.....:|::.|:||.|..:...||.|:..|..|
Human   294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQ 358

  Fly   384 QKVHEELKRLLPDPNTP-----LTIPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQ 443
            :.:|||:..::|....|     ..:||      ||..:||..|:|..|..|.|.:.::..:.|:.
Human   359 EALHEEVVGVVPAGQVPQHKDFAHMPL------LKAVLKETLRLYPVVPTNSRIIEKEIEVDGFL 417

  Fly   444 VPKGVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFA 508
            .||..|.||...|........::..:|:|.|||:.....||...|||.|:|:|||.|.|||||.|
Human   418 FPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIA 482

  Fly   509 DLEMQILLAKLLRNYKL 525
            :||||:|||:|::.||:
Human   483 ELEMQLLLARLIQKYKV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	126/484 (26%)
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	122/467 (26%)
CYP27A1	NP_000775.1	Sterol-binding. /evidence=ECO:0000255	384..398		7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820