Protein Alignment Cyp301a1 and CYP11B2

DIOPT Version :9

• Sequence 1: NP_610796.1
• Gene: Cyp301a1 / 36378
• FlyBaseID: FBgn0033753
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_000489.3
• Gene: CYP11B2 / 1585
• HGNCID: 2592
• Length: 503
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 117/509 - (22%)
• Similarity: 210/509 - (41%)
• Gaps: 67/509 - (13%)

  Fly    55 ASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTW-RLMPIIGQYTISDVAKISSLLHDRY---GR 115
            |.|||        ..||:..:| ..|    ||.| ||:.|   :.......:...:|..:   |.
Human    29 ARAPR--------TVLPFEAMP-QHP----GNRWLRLLQI---WREQGYEHLHLEMHQTFQELGP 77

  Fly   116 IVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGE 180
            |.|:.  :|.|.::.:...:::||..:.:...|.|..:...|.|     :...|...||..::|.
Human    78 IFRYN--LGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY-----RQHRGHKCGVFLLNGP 135

  Fly   181 PWREFRSRVQKPVLQLSTIRRYLQPLEVITEDF--LVRCENLLDENQELPEDFDNEIHKWSLECI 243
            .||..|.|:...||....::|:|..::.:..||  .::.:.|.:....|..|....|..:::|..
Human   136 EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200

  Fly   244 GRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRN-VATLELKAPYWRYFPTPLWTRYVKNMNFF 307
            .......|||.:..:  |.|.....:.|.:...:: |..:.:.....|:....:|..:.:..:..
Human   201 NLALFGERLGLVGHS--PSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 263

  Fly   308 VGVCMKYIQSATERLKTQDPSLRAGEPSLVEKVILSQKDEKIATIMA--LDLILVGIDTISMAVC 370
            .......||...:.|....|....|   :|.:::| :.:..:..|.|  ::|....:||.:..:.
Human   264 FQYGDNCIQKIYQELAFNRPQHYTG---IVAELLL-KAELSLEAIKANSMELTAGSVDTTAFPLL 324

  Fly   371 SMLYQLATRPVDQQKVHEE----LKRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMYSTVIGNG 430
            ..|::||..|..||.:.:|    ...:...|....| :||      |:..:||..|:|...:...
Human   325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPL------LRAALKETLRLYPVGLFLE 383

  Fly   431 RTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATF------RPERWLKPQHGGTPGKLHP 489
            |.:..|.|:..|.:|.|      |:|...:.....:||.|      .|:|||..:..|     ..
Human   384 RVVSSDLVLQNYHIPAG------TLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG-----RN 437

  Fly   490 FASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE-YNHKPLDYAVTFMYAP 542
            |..:|:|:|.|.|||||.|:.||.:||..:|:::.:| ...:.:....:|:..|
Human   438 FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	109/474 (23%)
CYP11B2	NP_000489.3	p450	42..454	CDD:365848	100/449 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820