DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and CYP11A1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_000772.2	Gene:	CYP11A1 / 1583	HGNCID:	2590	Length:	521	Species:	Homo sapiens

Alignment Length:	559	Identity:	140/559 - (25%)
Similarity:	234/559 - (41%)	Gaps:	78/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSTVSCGPNLRQCVPRISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQ 74
            ||.:..|.......|| .|.|..|....|.: |::|          .:||           |:|:
Human     9 RSVLVKGCQTFLSAPR-EGLGRLRVPTGEGA-GIST----------RSPR-----------PFNE 50

  Fly    75 IPGPKPIPILGNTWRLMPIIGQYTISDVAKISSLLH-----DRYGRIVRFGGLIGRPDLLFIYDA 134
            ||.|.     .|.|  :.:...:..:...|:.  ||     .:||.|.|  ..:|..:.:::.|.
Human    51 IPSPG-----DNGW--LNLYHFWRETGTHKVH--LHHVQNFQKYGPIYR--EKLGNVESVYVIDP 104

  Fly   135 DEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTI 199
            :::...::||||.|.|..:|..|.|....::..     ||:......|::.|..:.:.|:.....
Human   105 EDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI-----GVLLKKSAAWKKDRVALNQEVMAPEAT 164

  Fly   200 RRYLQPLEVITEDFLVRCENLLDE--NQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPD 262
            :.:|..|:.::.||:......:.:  :.....|..:::.:::.|.|..|....|.|.||..:.|
Human   165 KNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP- 228

  Fly   263 SEPQQIIDAAKYAL--RNVATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQ 325
             |.|:.|||. |.:  .:|..|.|....:|.|.|..|..:|...:........|.|:....|: |
Human   229 -EAQRFIDAI-YQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR-Q 290

  Fly   326 DPSLRAGEPSLVEKVI----LSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKV 386
            ..|:......::.:::    :|.:|.| |.:  .:::..|:||.||.:...||::|.....|..:
Human   291 KGSVHHDYRGILYRLLGDSKMSFEDIK-ANV--TEMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352

  Fly   387 HEEL----KRLLPDPNTPL-TIPLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPK 446
            ..|:    .:...|..|.| .:||      ||..|||..|::...:...|.|:.|.|:..|.:|.
Human   353 RAEVLAARHQAQGDMATMLQLVPL------LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPA 411

  Fly   447 GVQAVFPTIVTGNMEEYVTDAATFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLE 511
            ...........|....:..|...|.|.|||......|     .|.:|.:|:|.|.|||||.|:||
Human   412 KTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT-----YFRNLGFGWGVRQCLGRRIAELE 471

  Fly   512 MQILLAKLLRNYKLEYNHKPLDYAVTF--MYAPDGPLRF 548
            |.|.|..:|.|:::|..|.. |...||  :..|:.|:.|
Human   472 MTIFLINMLENFRVEIQHLS-DVGTTFNLILMPEKPISF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	117/471 (25%)
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	124/493 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820