Protein Alignment Cyp301a1 and Cyp11b1

DIOPT Version :10

• Sequence 1: NP_610796.1
• Gene: Cyp301a1 / 36378
• FlyBaseID: FBgn0033753
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001028401.3
• Gene: Cyp11b1 / 110115
• MGIID: 88583
• Length: 499
• Species: Mus musculus
• Alignment Length: 521
• Identity: 123/521 - (23%)
• Similarity: 214/521 - (41%)
• Gaps: 110/521 - (21%)

  Fly    84 LGNTWRLMP-------IIGQYTISDVAKISSLLHDR---------------YGRIVRFGGLIGRP 126
            ||.|..|.|       .|.||:.:...|:..:|.::               .|.|.|..  :|:.
Mouse    24 LGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHS--VGKT 86

  Fly   127 DLLFIYDADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQK 191
            .::|:...:::||.|:.|...|.|..:.|.     :|.::..|...||..::|..|...|.::..
Mouse    87 QIVFVTLPEDVEKLYQVESTHPCRMPLESW-----IVHRELRGLGRGVFLLNGPEWYFNRLQLNP 146

  Fly   192 PVLQLSTIRRYLQPLEVITEDFLVRCENLLDENQE-----LPEDFDNEIHKWSLECIGRVALDTR 251
            .||....:::::..::.|..||:   :||..:..|     ...||.:.:..:::|....|....|
Mouse   147 NVLSPKAVQKFVPLVDGIARDFV---DNLKKKMLESVHGSFSMDFQSSVFNYTIEASHFVLFGER 208

  Fly   252 LGCLESNLKPDSEPQQIIDAAKYALRNVATLE-----------LKAPYWRYFPTPLWTRYVKNMN 305
            ||.:..:|.|||            |:.:.||.           |.....|:..|.:|...:::.:
Mouse   209 LGLIGRDLSPDS------------LKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWD 261

  Fly   306 F---FVGVCMKYIQSATERLKTQDPSLRAGEPS--LVEKVILSQKDEKIATIMA--LDLILVGID 363
            |   :|..|:|.:..          .|..|.|.  .|...:::::...:..|.|  ::||....|
Mouse   262 FISEYVTKCIKNVYR----------ELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTD 316

  Fly   364 TISMAVCSMLYQLATRPVDQQKVHEEL----KRLLPDPNTPLT-IPLLDQMHHLKGFIKEVFRMY 423
            |.|..:....::||..|..||.:.:|.    ..:..:|...:: :||      |:..:||..|:|
Mouse   317 TTSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAMSDLPL------LRAALKETLRLY 375

  Fly   424 STVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATF------RPERWLKPQHGG 482
            .......|.|..|.|:..|.||.|      |::..|:.....:.|.|      .|:|||:
Mouse   376 PVGTFLERILSSDLVLQNYHVPAG------TVLNVNLYSMGRNPAVFPRPERYMPQRWLE----- 429

  Fly   483 TPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYNHK-PLDYAVTFMYAP-DGP 545
               :...|..|.:|:|.|.|||||.|:.||.:||..:|:::.:|...| .:..|..|:..| ..|
Mouse   430 ---RKRSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPSSSP 491

  Fly   546 L 546
            |
Mouse   492 L 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	CYP24A1-like	110..547	CDD:410677	113/488 (23%)
Cyp11b1	NP_001028401.3	cytochrome_P450	72..495	CDD:477761	113/473 (24%)