DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp301a1 and cyp24a1

DIOPT Version :9

Sequence 1:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001082927.1	Gene:	cyp24a1 / 100004700	ZFINID:	ZDB-GENE-060825-1	Length:	505	Species:	Danio rerio

Alignment Length:	538	Identity:	139/538 - (25%)
Similarity:	242/538 - (44%)	Gaps:	85/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CRESSTGVATCPHLADSEEA--SAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRLMPIIGQYT 98
            |:.:|   :.|  :.||::|  |||..||         .:.||||...|:.|:   |:.:|....
Zfish    25 CKPTS---SVC--VLDSKDAAGSAPCAHS---------LDSIPGPTNWPLFGS---LIEVIRNGG 72

  Fly    99 ISDVAKISSLLHDRYGRIVR--FGGL----IGRPDLLFIYDADEIEKCYRSEGPTPFRPSMPSLV 157
            :....:.....|.::|:|.|  .|..    ||.|.||        |..||.||..|.|..:....
Zfish    73 LKRQHETLIHFHKKFGKIFRMKLGSFESVHIGSPCLL--------EALYRKEGSYPERLEIKPWK 129

  Fly   158 KYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCENLLD 222
            .|     :|...:..|::.:.|..|:..||..|:.:::.:.:.:....:..:..|.:.|...:..
Zfish   130 AY-----RDMRDEAYGLLILEGRDWQRVRSAFQQKLMKPTEVMKLDGKINEVAADLIKRIGKVNG 189

  Fly   223 ENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATL----- 282
            :...|    ..|::|||.|.|..|..|.|.|.|:.::  ..|....|.|.|..:....|:
Zfish   190 KMDAL----YFELNKWSFETICYVIYDKRFGLLQDSV--SKEGMDFITAVKTMMSTFGTMMVTPV 248

  Fly   283 ----ELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAGE-----PSLVE 338
                .|....|:.. |..|.|.......::.   |.:|..:.           ||     ..:..
Zfish   249 ELHKTLNTKTWKDH-TEAWDRIFSTAKHYID---KNLQKQSN-----------GEADDFLSDIFH 298

  Fly   339 KVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTI 403
            ...|::|:...||   .:|.:.|::|.:.::..:::.|:..|..|.|:.:|::.::|...|| ..
Zfish   299 NGNLTKKELYAAT---TELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKEIQDVVPAGQTP-RA 359

  Fly   404 PLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAA 468
            ..:..|.:||..:||..|:..:|....|||.:|:|:..|.:|||...:..:...|..|||..:..
Zfish   360 EHIKSMPYLKACLKESMRVSPSVPFTSRTLDKDTVLGDYTLPKGTVLMLNSQAIGVSEEYFDNGR 424

  Fly   469 TFRPERWLKPQHGGTPGKLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKL-EYNHKPL 532
            .|||||||:.:     ..::|||.:|:|.|.|||:|||.|:|::|:.|..:||:||: ..:.:|:
Zfish   425 QFRPERWLEEK-----SSINPFAHVPFGVGKRMCIGRRLAELQIQLGLCWILRDYKIVATDLEPV 484

  Fly   533 D--YAVTFMYAPDGPLRF 548
            |  ::.|.:.:.:.|:.|
Zfish   485 DSLHSGTLVPSRELPVAF 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	122/474 (26%)
cyp24a1	NP_001082927.1	p450	53..493	CDD:278495	125/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.970