DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Robo2

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_038944599.1 Gene:Robo2 / 84409 RGDID:620167 Length:1625 Species:Rattus norvegicus


Alignment Length:1792 Identity:366/1792 - (20%)
Similarity:569/1792 - (31%) Gaps:679/1792 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 CLIFQLIGSSLASQAL--------SFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSV 76
            |:....:|.:::..|.        .|...|.|.||..|...:|:|...    ||....       
  Rat   133 CVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP----RGHPEP------- 186

  Fly    77 SIRWRGPDGQDLVIVGD-TFRTQLKNGSLYISSVEENRGLTGAYQCLLTAEGVGSILSRPALVAI 140
            :|.|:    :|.|.:.: ..|..::.|.|.||:..::.  .|.|.|:.| ..||...|.||.:.:
  Rat   187 TIYWK----KDKVRIDEKEERISIRGGKLMISNTRKSD--AGMYTCVGT-NMVGERDSDPAELTV 244

  Fly   141 VRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALE 205
            ..:|...:..:...:|..:.|.|||.:     |...:.:|:|.|||..||  :.|..:..:..|.
  Rat   245 FERPTFLRRPINQVVLEDEPAEFRCQV-----QGDPQPTVRWKKDDADLP--RGRYDIKDDYTLR 302

  Fly   206 IDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIK-KPSDPGAENSVAPSFLVGPSPKTVREGDTVT 269
            |.:...:|.|:|.| :......::.:...|.:: :|..|       |.|:|.|..:.|.:|.|||
  Rat   303 IKKAISADEGTYVC-IAENRVGKVEASATLTVRVRPVAP-------PQFVVRPRDQIVAQGRTVT 359

  Fly   270 LDCVANGVPKPQIKWLRNG-MDLDF----NDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTV 329
            ..|...|.|:|.:.|.:.| .:|.|    ...:||.|:..||.|.|::.:..|:|.|.|:|....
  Rat   360 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVA 424

  Fly   330 DSLDAQATVQVQE------PPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPND 388
            .|:.|:|.::|.:      ||..::.|.:.|........|||...|:|.|||.|||.|......|
  Rat   425 GSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTALLKCKATGEPLPVISWLKEGFTFLGRD 489

  Fly   389 YMQLV-DGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQT 452
            ....: |...|:|..|..||.|.:.||.|:::|....:|.|.|...|..|.|             
  Rat   490 PRATIQDQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISK------------- 541

  Fly   453 FDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNI 517
                                            :.|.||                           
  Rat   542 --------------------------------NYDTND--------------------------- 547

  Fly   518 LNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSP 582
                  ||                 ..|:|..:.:..|     :.:..|||             |
  Rat   548 ------LP-----------------GPPSKPQVTDVTK-----NSVTLSWQ-------------P 571

  Fly   583 ASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVK--SRFVTLSWVEPLQNAGDVVYYT 645
            .:|                   |:   ||:.     |.|::  |:.|:.||    |...:.|..|
  Rat   572 GTP-------------------GV---LPAS-----AYIIEAFSQSVSNSW----QTVANHVKTT 605

  Fly   646 VYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIA 710
            :|                      .::.|.|...|.|.|.|....|   .|.|..:|........
  Rat   606 LY----------------------TVRGLRPNTIYLFMVRAINPQG---LSDPSPMSDPVRTQDI 645

  Fly   711 GPPRNFEGYARSHKE------------------IYVKW---EEPTVTNGEILKYRVYYSEND--S 752
            .||.....:.:..||                  :.|.|   .:|....|    |||.|.:..  .
  Rat   646 SPPAQGVDHRQVQKELGDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQG----YRVMYRQTSGLQ 706

  Fly   753 GADLYHD-----STALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVT 812
            .:.::.:     .|...|||..|:....|.|.|.|:.....|..|....::|....||.||.:||
  Rat   707 ASTVWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSAPPQSVT 771

  Fly   813 -LEVTS--SSSITVHWEPPAEEDRNGQITGYKI-------RYRKFKDAPQVKSTPANIRYFELSN 867
             |.|.|  |:||:|.|:||..:.:||.|..|||       |:.      ..|:..|.||...:..
  Rat   772 VLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFH------INKTVDATIRSVVIGG 830

  Fly   868 LDRNAEYQVKIAAMTVNGSG----------------PFTEWNRANTLENDLDETQVP-------- 908
            |....:|:|::||.|..|.|                ..||.|.:.| |...|..:.|        
  Rat   831 LFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSIT-EQITDVVKQPAFIAGIGG 894

  Fly   909 -------GKPIWI----SIHPGANNIA-------------------LHWGPPQHP---------E 934
                   |..||:    ....|.:|.|                   |:.|.|.:|         .
  Rat   895 ACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNTGDPSYPWLADSWPATS 959

  Fly   935 IKIRNYVLG------WGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDN 993
            :.:.|...|      :|||           ..::::.|||..:                     .
  Rat   960 LPVNNSNSGPNEIGNFGRG-----------DFKHNVNKNLAEH---------------------G 992

  Fly   994 IK------TRDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGIT 1052
            ||      .|::..|..|.|.:   |.:..||.|...:...||        .|....|..|..||
  Rat   993 IKKEFLGMERNKNDVLPPVPGQ---GDKTATMLSDGAIYSSID--------FTTKTTYNSSSQIT 1046

  Fly  1053 GSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRL 1117
            .:..|.   ||.:      |..|:.:|.||.:    .:..|..||...:                
  Rat  1047 QATPYA---TTQI------LHSNSIHELAVDL----PDPQWKSSVQQKS---------------- 1082

  Fly  1118 DEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYF 1182
                                .:.|: .|...|..|           |...:|.:|:.        
  Rat  1083 --------------------DLMGF-AYSLPDQNK-----------GNNALLYIPDY-------- 1107

  Fly  1183 KVQARTTKG-ANNAPFSALVSY-TTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGV 1245
                |..:| :|..|.:....: |||:..:.:...:::.|...:|                    
  Rat  1108 ----RLAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKK-------------------- 1148

  Fly  1246 LLLCRRKPQSSPEHTKKSYQKN------NVGVPKPP----------------------DLW---- 1278
                 :|.::|     ...|||      ||.:|.||                      |.|    
  Rat  1149 -----KKTKNS-----SKAQKNNGSTWANVPLPPPPVQPLPGTELGHYPAEQENGYDSDSWCPPL 1203

  Fly  1279 -----IH---HDQMELKNID-------KGLHTVTPVCSDGASSSGALT-LPRSVVHS-------- 1319
                 :|   .|::| ::.|       :|:.: :|..|.|..|:..|| .||..:..        
  Rat  1204 PVQTYLHQGMEDELE-EDEDRVPTPPVRGVAS-SPAISFGQQSTATLTPSPREEMQPMLQAHLDE 1266

  Fly  1320 -----EYEV--------------ETPVP--GHVTNSL--DKRSYVPGYMTTSMNGTMERPQYPRT 1361
                 ::::              :.|||  |:.:.:|  |..:.||..........:|.|:..|.
  Rat  1267 LTRAYQFDIAKQTWHIQSNTPPPQPPVPPLGYASGALISDLETDVPDEDADDEEEPLEIPRPLRA 1331

  Fly  1362 QYSHQNRSHMTMEAGLSQQSLTQPQSNSM------AQTPEHPYGGY--------------DANFC 1406
                     :....|.|..:|....:.||      |...:..:..:              ..:|.
  Rat  1332 ---------LDQTPGSSMDNLDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIFASGSFA 1387

  Fly  1407 NAGNAAA--------GNGCVST---IESSKRGHPLKSFSVPGPPPTGGATPVTKHTPAVTIRPQN 1460
            .|..|||        |.....|   ..||:|..|...||                |.:.|...||
  Rat  1388 QALVAAADKAGFRLDGTSLTRTGKAFTSSQRQRPTSPFS----------------TDSNTSAAQN 1436

  Fly  1461 QSPYKKPSF---------SAATPNRLQG--------------------------GGSVVHSTDEI 1490
            ||...:|:.         ....|:|.:|                          .|:|..||:. 
  Rat  1437 QSQRPRPTKKHKGGRMDPQPVLPHRREGMPDDLPPPPDPPPGQGLRQQIGLSQHSGNVESSTER- 1500

  Fly  1491 QRLAPSTSTEELNQEMANLEGLMK--DLSAITANEFE 1525
                ..:|.|  .|:.||||....  |..|.|..|::
  Rat  1501 ----KGSSLE--RQQAANLEDTKSSLDCPAKTTVEWQ 1531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 28/104 (27%)
Ig <180..222 CDD:299845 14/41 (34%)
IG_like 257..340 CDD:214653 29/87 (33%)
IGc2 264..327 CDD:197706 24/67 (36%)
I-set 344..430 CDD:254352 29/86 (34%)
Ig 363..428 CDD:299845 25/65 (38%)
FN3 611..703 CDD:238020 20/93 (22%)
FN3 711..799 CDD:238020 23/115 (20%)
FN3 806..897 CDD:238020 36/116 (31%)
FN3 908..989 CDD:238020 19/133 (14%)
FN3 1011..1097 CDD:238020 20/85 (24%)
FN3 1109..1205 CDD:238020 11/97 (11%)
Neogenin_C 1273..1521 CDD:284094 70/388 (18%)
Robo2XP_038944599.1 IgC_1_Robo 54..152 CDD:409490 3/18 (17%)
Ig strand B 71..75 CDD:409490
Ig strand C 84..88 CDD:409490
Ig strand E 111..115 CDD:409490
Ig strand F 130..135 CDD:409490 1/1 (100%)
Ig strand G 144..147 CDD:409490 0/2 (0%)
Ig 159..244 CDD:416386 27/102 (26%)
Ig strand A 159..162 CDD:409353 0/2 (0%)
Ig strand A' 164..168 CDD:409353 2/3 (67%)
Ig strand B 172..179 CDD:409353 2/6 (33%)
Ig strand C 187..192 CDD:409353 2/8 (25%)
Ig strand C' 194..197 CDD:409353 1/2 (50%)
Ig strand D 203..207 CDD:409353 1/3 (33%)
Ig strand E 209..215 CDD:409353 3/5 (60%)
Ig strand F 222..230 CDD:409353 4/8 (50%)
Ig strand G 233..244 CDD:409353 4/10 (40%)
Ig 251..333 CDD:416386 21/89 (24%)
Ig strand A 251..254 CDD:409353 0/2 (0%)
Ig strand A' 256..260 CDD:409353 0/3 (0%)
Ig strand B 263..272 CDD:409353 4/13 (31%)
Ig strand C 278..283 CDD:409353 2/4 (50%)
Ig strand C' 286..289 CDD:409353 0/2 (0%)
Ig strand D 292..297 CDD:409353 1/4 (25%)
Ig strand E 298..305 CDD:409353 2/6 (33%)
Ig strand F 312..320 CDD:409353 3/8 (38%)
Ig strand G 323..333 CDD:409353 1/9 (11%)
IgI_4_Robo 342..439 CDD:409391 32/96 (33%)
Ig strand B 358..362 CDD:409391 2/3 (67%)
Ig strand C 371..375 CDD:409391 0/3 (0%)
Ig strand E 401..405 CDD:409391 2/3 (67%)
Ig strand F 415..420 CDD:409391 2/4 (50%)
Ig strand G 428..431 CDD:409391 1/2 (50%)
IgI_5_Robo 446..532 CDD:409544 28/85 (33%)
Ig strand B 462..466 CDD:409544 1/3 (33%)
Ig strand C 475..479 CDD:409544 2/3 (67%)
Ig strand E 498..502 CDD:409544 1/3 (33%)
Ig strand F 512..517 CDD:409544 1/4 (25%)
Ig strand G 525..528 CDD:409544 0/2 (0%)
FN3 549..642 CDD:238020 32/183 (17%)
FN3 673..758 CDD:238020 19/88 (22%)
FN3 767..859 CDD:238020 32/97 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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