DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Neo1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_038938340.1 Gene:Neo1 / 81735 RGDID:619837 Length:1492 Species:Rattus norvegicus


Alignment Length:1619 Identity:506/1619 - (31%)
Similarity:749/1619 - (46%) Gaps:302/1619 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QLIGSSLAS-QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQD 87
            |..|:|:.: ..|.|.:||.|.:...|.||:|.|:..:.            .|.:|.|: .||..
  Rat    52 QSAGASVRTFTPLYFLVEPVDTLSVRGSSVILNCSAYSE------------PSPNIEWK-KDGTF 103

  Fly    88 LVIVGDTFRTQLKNGSLYISSV---EENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQD 149
            |.:|.|..|..|.:|||:||:|   :.|:...|.|||:.|.:.:|:|:||.|.:|:...|.....
  Rat   104 LNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLAVAGLPRFTSQ 168

  Fly   150 FLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDR 214
            ...:.:..|.:....|   |.|  ..:...|:|.::..||.||. |:|.||:|.|.|......|.
  Rat   169 PEPSSIYVGNSGILNC---EVN--ADLVPFVRWEQNRQPLLLDD-RIVKLPSGTLVISNATEGDE 227

  Fly   215 GSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPK 279
            |.|:|.|.||...:.|.:..|.:.:.|    |..:...||:.||......|.:..|.|||:|:|.
  Rat   228 GLYRCIVESGGPPKFSDEAELKVLQES----EEMLDLVFLMRPSSMIKVIGQSAVLPCVASGLPA 288

  Fly   280 PQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPP 344
            |.|:|::|...|| .:...|.:::..|||:||...:.|:|.|.|.|.|...:::|||.:.||.||
  Rat   289 PVIRWMKNEDVLD-TESSGRLALLAGGSLEISDVTEDDAGTYFCVADNGNKTIEAQAELTVQVPP 352

  Fly   345 KFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAG 409
            :|:|.|.:..|.|..:...:|::.|||.|.::|:||||::.|:||.::|..|||::|||:.||.|
  Rat   353 EFLKQPANIYARESMDIVFECEVTGKPAPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEG 417

  Fly   410 MFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSG 474
            .:||:..|..|:..|.|:|.::...|.|                                     
  Rat   418 FYQCIAENDVGNAQAGAQLIILEHDVAI------------------------------------- 445

  Fly   475 GSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDD 539
                                                           ..||              
  Rat   446 -----------------------------------------------PTLP-------------- 449

  Fly   540 YDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDS 604
                                                      |.|..|...|...|...|.    
  Rat   450 ------------------------------------------PTSLTSATTDHLAPATTGP---- 468

  Fly   605 GLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNA-GDVVYYTVYYKMNNSEREQKMVTKSHDDQQ 668
                 |||.|||:||.:|.:||:.|:|..|..:. ||.:.|:|:|......||:...|....:.|
  Rat   469 -----LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQ 528

  Fly   669 VNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEP 733
            |.||:|:|...|.|:|.|....|||.|||||.|.|||||.:.||..|...||.|...|.|.||.|
  Rat   529 VTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETP 593

  Fly   734 TVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVK 798
            ...||||..|::||.|..:..:...|.::....:..|:.:|:|...||.:|::|.|.|:.::.|:
  Rat   594 LSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVR 658

  Fly   799 TFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYF 863
            |.|..||..|.|::|||.:|.||.:||:||:...:|||||||||||||......|..|.......
  Rat   659 TLSDVPSAAPQNLSLEVRNSKSIVIHWQPPSSATQNGQITGYKIRYRKASRKSDVTETVVTGTQL 723

  Fly   864 E--LSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALH 926
            .  :..|||..||..::||:||||:||.|:|..|.|.|:||||::||..|..:.:.|...:|.:.
  Rat   724 SQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVTSIVVS 788

  Fly   927 WGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIY 991
            |.||::..|.:|.|.:|:|.|.|...||::...:||:.::||:.:..||::|:|.|..|:|.|:|
  Rat   789 WTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLY 853

  Fly   992 DNIKTRDE---------------EPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTD 1041
            ::..||..               .||..|||:..|||::|..:|..:|.:.|.|..|.|:|.:||
  Rat   854 ESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITD 918

  Fly  1042 NRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQN 1104
            :|:|||.:  .|..:.:|:..|.|.|:.::..|:|||.|||:|.|.||||.|:|||:...:|::.
  Rat   919 SRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFEL 983

  Fly  1105 VPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETML 1169
            ||.:||::|||...|..|.|:||.|.||....|:||||.|||:||......||.:|...|.....
  Rat   984 VPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTH 1048

  Fly  1170 MLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQE-PDTIAKG------------- 1220
            .:..|...|.||||:|||.:||.  .|.|..|.:.|..|.:..: |:..|.|             
  Rat  1049 QIQELTLDTPYYFKIQARNSKGM--GPMSEAVQFRTPKADSSDKMPNDQALGSAGKGGRLPDLGS 1111

  Fly  1221 -------------------IDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK---- 1262
                               :|:..|| :||.:..|:.:||::.:.:.|.|:..|   |.||    
  Rat  1112 DYKPPMSGSNSPHGSPTSPLDSNMLL-VIIVSIGVITIVVVVIIAVFCTRRTTS---HQKKKRAA 1172

  Fly  1263 ------SYQ-KNNVGVPKPPDLWIHHDQMELKNIDK---------------GLHTVTPV------ 1299
                  |:: |.|....|||||||||:::|||.|||               ....:|||      
  Rat  1173 CKSVNGSHKYKGNCKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDS 1237

  Fly  1300 -------------CSDGASSSGALTLPRSVVHSEYEVETPVP---GHVTNSLDK--RSYVPGYMT 1346
                         ..|..|:.......|..:...::.:.|.|   .|..:|||.  ..:....:.
  Rat  1238 NIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLA 1302

  Fly  1347 TSMNGTMERPQYP---RTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEH--PYGGYDANFC 1406
            :.....:..|..|   .|..|..:|::.|.....:..:.|.|.|:|.....:|  |.|...:::.
  Rat  1303 SPARSHLYHPSSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYL 1367

  Fly  1407 NAGNAAAGNGCVSTIESSKRGHPLKSFSVPGPPPTGGA--TPVTKHTPAVTIRPQNQSPYKKPSF 1469
             |.:....:|........:..||||||:||..||.|..  .|....||.::.:..|...:...:.
  Rat  1368 -ASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPIYDPALPSTPLLSQQALNHHLHSVKTA 1431

  Fly  1470 SAATPNRLQGG-GSVVHSTDEIQR----LAPSTST---EELNQEMANLEGLMKDLSAIT 1520
            |..|..|.:.. ..||.|..|:|.    |..|.|:   :||.:|||:||||||||:|||
  Rat  1432 SIGTLGRSRPPMPVVVPSAPEVQEATRMLEDSESSYEPDELTKEMAHLEGLMKDLNAIT 1490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 36/106 (34%)
Ig <180..222 CDD:299845 17/41 (41%)
IG_like 257..340 CDD:214653 30/82 (37%)
IGc2 264..327 CDD:197706 24/62 (39%)
I-set 344..430 CDD:254352 36/85 (42%)
Ig 363..428 CDD:299845 29/64 (45%)
FN3 611..703 CDD:238020 40/92 (43%)
FN3 711..799 CDD:238020 30/87 (34%)
FN3 806..897 CDD:238020 43/92 (47%)
FN3 908..989 CDD:238020 27/80 (34%)
FN3 1011..1097 CDD:238020 39/87 (45%)
FN3 1109..1205 CDD:238020 41/95 (43%)
Neogenin_C 1273..1521 CDD:284094 84/302 (28%)
Neo1XP_038938340.1 IgI_1_Neogenin_like 63..159 CDD:409387 37/108 (34%)
Ig strand B 81..85 CDD:409387 2/3 (67%)
Ig strand C 94..98 CDD:409387 1/3 (33%)
Ig strand E 118..122 CDD:409387 3/3 (100%)
Ig strand F 137..142 CDD:409387 3/4 (75%)
Ig strand G 152..155 CDD:409387 2/2 (100%)
Ig 163..250 CDD:416386 27/92 (29%)
Ig strand C 193..197 CDD:409353 1/3 (33%)
Ig strand E 215..219 CDD:409353 2/3 (67%)
Ig strand F 229..234 CDD:409353 2/4 (50%)
Ig strand G 243..246 CDD:409353 1/2 (50%)
Ig 263..348 CDD:416386 31/85 (36%)
Ig strand A 263..266 CDD:409353 1/2 (50%)
Ig strand A' 268..272 CDD:409353 0/3 (0%)
Ig strand B 275..284 CDD:409353 3/8 (38%)
Ig strand C 290..295 CDD:409353 2/4 (50%)
Ig strand C' 298..304 CDD:409353 2/6 (33%)
Ig strand D 307..312 CDD:409353 1/4 (25%)
Ig strand E 313..320 CDD:409353 4/6 (67%)
Ig strand F 327..335 CDD:409353 4/7 (57%)
Ig strand G 338..348 CDD:409353 3/9 (33%)
IgI_4_Neogenin_like 355..438 CDD:409388 34/82 (41%)
Ig strand B 369..373 CDD:409388 0/3 (0%)
Ig strand C 382..386 CDD:409388 0/3 (0%)
Ig strand E 404..408 CDD:409388 3/3 (100%)
Ig strand F 418..423 CDD:409388 2/4 (50%)
Ig strand G 431..434 CDD:409388 1/2 (50%)
FN3 470..563 CDD:238020 40/92 (43%)
FN3 570..659 CDD:238020 30/88 (34%)
FN3 667..759 CDD:238020 43/91 (47%)
FN3 770..849 CDD:214495 26/78 (33%)
FN3 887..980 CDD:238020 39/92 (42%)
FN3 987..1082 CDD:238020 41/96 (43%)
Neogenin_C 1189..1492 CDD:399527 84/303 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 92 1.000 Domainoid score I7420
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1870
Inparanoid 1 1.050 786 1.000 Inparanoid score I493
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm45219
orthoMCL 1 0.900 - - OOG6_105369
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.980

Return to query results.
Submit another query.