DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and si:ch211-57n23.4

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_009292645.2	Gene:	si:ch211-57n23.4 / 799595	ZFINID:	ZDB-GENE-140106-153	Length:	722	Species:	Danio rerio

Alignment Length:	895	Identity:	184/895 - (20%)
Similarity:	293/895 - (32%)	Gaps:	340/895 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLSSCLIFQLIGSSLAS-QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIR 79
            :|.:.|.|  |||.|.: ..|:|.:||.|.:......::|.|...   |.|         .:::.
Zfish     5 ILLTFLTF--IGSCLCNGSELAFLIEPSDVIAVRDRPLMLDCRVE---GEG---------PITVT 55

  Fly    80 WRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRG----LTGAYQCLLTAEGVGSILSRPALVAI 140
            |.......|..:|...:. |.||:|.|.|.::.|.    ..|.|.| ......|.::||.|.|.:
Zfish    56 WHKNGAPLLAGIGSRVKI-LSNGTLLIRSFQKRRDGDATDAGEYYC-AAQNHYGMLVSRKARVQL 118

  Fly   141 VRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGV-KHSVQWLKDDLPLPLDKLRMVVLPNGAL 204
            ...|..:.......:..|..|.|:|.:      .|: :.|:.|.||.:.|.....|..:||.|.|
Zfish   119 ASLPKFHTHPESMSVDDGGVARFQCQV------NGIPEASITWEKDHVVLGTSDDRYTLLPMGIL 177

  Fly   205 EIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSV-APSFLVGPSPKTVREGDTV 268
            :|..|..:|.|.|:|..::.:::|.|.:.:||:    ..|...:. .|..|.||...|:....|.
Zfish   178 QITGVKKADAGIYRCVASNIANTRYSHEAHLNV----TGGVPRTYKEPVILSGPQNLTITVHQTA 238

  Fly   269 TLDCVANGVPKPQIKWLRNGMDLDFNDLDSR------FSIVGTGSLQISSAEDIDSGNYQCRAS- 326
            .|:|:|.|.|:|.:.|.|         ||.|      ..::|||:|.||......||.|.|.|:
Zfish   239 ILECIATGNPRPIVSWSR---------LDGRSIGVEGIQVLGTGNLMISDVSLQHSGVYVCAANR 294

  Fly   327 -NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYM 390
             .|.....|...:.||.||:||:.|:..:..........|...|.|:|.|.|||||.::||.|.:
Zfish   295 PGTRMRRTALGRLVVQAPPEFIQWPQSVSKPAGGSAVFTCVAQGVPEPHIIWLKNGKILTPGDNV 359

  Fly   391 QLVDGHN-LKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFD 454
            :|.:.:: |.:..:.:.|..::||:..|.||:..|:|||.|                  ||
Zfish   360 KLTNNNSTLAVTRITSEDEAIYQCIAENTAGTNQASARLAV------------------SL---- 402

  Fly   455 NLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILN 519

Zfish   403 ----------------------------------------------------------------- 402

  Fly   520 AGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPAS 584
                                      |||
Zfish   403 --------------------------AKE------------------------------------ 405

  Fly   585 PDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGD-VVYYTVY- 647
                                     ||..|:.|.|..:....:.|||.:|.....| ::.|.::
Zfish   406 -------------------------LPDSPQGLKATALSKTSLQLSWTQPPAEVTDGIIGYVLHI 445

  Fly   648 --YKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIA 710
              |..:.|:..|:.|:|:               |:|
Zfish   446 RKYGESESKELQEAVSKT---------------TFQ----------------------------- 466

  Fly   711 GPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTD 775
                                                           ||       ||.|.|.|.
Zfish   467 -----------------------------------------------HD-------LTNLEPATT 477

  Fly   776 YVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGY 840
            |.|.:..::..|....|:.:...|....|| ||...| :..:::::.|.||.|   ::.|:..|:
Zfish   478 YSIYLKAYSPLGASQQSSTVVSTTLGGVPS-PPTFFT-KAINATAVQVLWELP---NKPGKAEGF 537

  Fly   841 KIRYRKFKDAPQVK-----STPANIRYFELSNLDRNAEYQVKIAAMTVNG 885
            ::.||:   .|..:     ..|.::....:|:||..|.|:||:.|...||
Zfish   538 RLTYRR---VPHGEMQGPIQLPCHVNAHIISHLDAGAVYEVKLVAYNGNG 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	26/107 (24%)
		Ig	<180..222	CDD:299845	15/41 (37%)
		IG_like	257..340	CDD:214653	27/90 (30%)
		IGc2	264..327	CDD:197706	23/70 (33%)
		I-set	344..430	CDD:254352	29/86 (34%)
		Ig	363..428	CDD:299845	23/65 (35%)
		FN3	611..703	CDD:238020	17/95 (18%)
		FN3	711..799	CDD:238020	11/87 (13%)
		FN3	806..897	CDD:238020	23/85 (27%)
		FN3	908..989	CDD:238020
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
si:ch211-57n23.4	XP_009292645.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810