DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Robo4

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_006510707.1	Gene:	Robo4 / 74144	MGIID:	1921394	Length:	1074	Species:	Mus musculus

Alignment Length:	1038	Identity:	226/1038 - (21%)
Similarity:	344/1038 - (33%)	Gaps:	324/1038 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 PSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQI----- 310
            |..||.|..:.::......:.|.::|.|.|.|:||.||..|.....|..: ::..|:|.:
Mouse    42 PQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHY-LLPDGTLLLHRPSV 105

  Fly   311 ----SSAEDIDS---GNYQCRASN---TVDSLDAQATVQV-QEPPKFIKAPKDTTAHEKDEPELK 364
                ...::|.|   |.|.|.|||   |..|..|:.:|.| ||  .|...|:||.|...:...|:
Mouse   106 QGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQE--DFQIQPRDTVAVVGESLVLE 168

  Fly   365 C-DIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHA-AAR 427
            | ..||.|||.:.|.|:|..:......:.|.|.:|.:.....:|:|.:.|:.||.||...: |||
Mouse   169 CGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAAR 233

  Fly   428 LRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSG 492
            :.:         ::||.|.    :..:.|..|.:..|
Mouse   234 VSI---------QESQDHK----EHLELLAVRIQLEN---------------------------- 257

  Fly   493 TTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQG 557
            .|.|.....|.||   |......:...:|.|.|.::.:..:.......|:..|..|.||...:..
Mouse   258 VTLLNPEPVKGPK---PGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSA 319

  Fly   558 E--DAHKILDSWQQSKSKKSQQQKQSPASPDS-------PEQDPSVPHPGGKPLDSGLQARLPSQ 613
            :  ..|     |.|....|.:........|||       |||.||.| |.|..|.||
Mouse   320 KLGGLH-----WGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAP-PQGVTLRSG-------- 370

  Fly   614 PRDLVAQIVKSRFVTLSWVEPLQNA--GDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLP 676
                      :..|.:||..|...:  |.:..|.| :.:.|:.......|...:..|:.|.:.||
Mouse   371 ----------NGSVFVSWAPPPAESHNGVIRGYQV-WSLGNASLPAANWTVVGEQTQLEIATRLP 424

  Fly   677 GRTYQFRVEANTNFGSGASSAP----------LEVSTQP-------------------------- 705
            | :|..:|.|.|..|:|..|.|          |.:|:.|
Mouse   425 G-SYCVQVAAVTGAGAGELSTPVCLLLGEGKALSISSTPPPCRPSVSQFLSYIFSSSLSCLLVPL 488

  Fly   706 EVNIAGP-------PRNFEGYARSHKEIYVKWE----EPTVTNGEILK----------------- 742
            .|.:|.|       .:..|..||..:: :|.|.    ..|:...|::.
Mouse   489 TVPLALPLSSTSQTEQAMEQSARDPRK-HVPWTLEQLRATLRRPEVIASSAVLLWLLLLGITVCI 552

  Fly   743 YRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEP 807
            ||...:....|..||. .|:.:|:|.....|:|     .|:    :.|        |:.||..
Mouse   553 YRRRKAGVHLGPGLYR-YTSEDAILKHRMDHSD-----SPW----LAD--------TWRSTSG-- 597

  Fly   808 PNNVTLEVTSSSSIT-----------------VHWEP-----PAEEDRNGQITGYKIRYRKFKDA 850
                :.:::||||::                 :.|:|     |...|.:   |.|.....:...:
Mouse   598 ----SRDLSSSSSLSSRLGLDPRDPLEGRRSLISWDPRSPGVPLLPDTS---TFYGSLIAEQPSS 655

  Fly   851 PQVK---STPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTL---------ENDLD 903
            |.|:   .|||..|            :..|:|       |..:.|..:::|         ...|.
Mouse   656 PPVRPSPKTPAARR------------FPSKLA-------GTSSPWASSDSLCSRRGLCSPRMSLT 701

  Fly   904 ETQVPGKPIWIS-----IHPGANNIALHWGPPQHPEIKIRNYVLGWGRG---------IPDENTI 954
            .|:.     |.:     :|. ||:..|..|  .||     ..:..|..|         .|..|:.
Mouse   702 PTEA-----WKAKKKQELHQ-ANSSPLLRG--SHP-----MEIWAWELGSRASKNLSQSPGPNSG 753

  Fly   955 ELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPLEVPVGLRAITM 1019
            ...|..|            .|||.||     .||.::.|.......|: .||||    .||..:.
Mouse   754 SPGEAPR------------AVVSWRA-----VGPQLHRNSSELASRPL-PPTPL----SLRGASS 796

  Fly  1020 SSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKV 1084
            ....      ...:.|.|..:.:........:..|:|......:.|:|      |:.
Mouse   797 HDPQ------SQCVEKLQAPSSDPLPAAPLSVLNSSRPSSPQASFLSC------PSP-------- 841

  Fly  1085 VKGRRESSWSMSVLNSTYQNVPVTPPREVTVRL---DEMNPPTVIVQWIP----PKHTLGQIT 1140
             .....||.|:|.|........|..|.||.:.|   |....||..|..:|    |..|.|.|:
Mouse   842 -SSSNLSSSSLSSLEEEEDQDSVLTPEEVALCLELSDGEETPTNSVSPMPRAPSPPTTYGYIS 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845
		IG_like	257..340	CDD:214653	26/97 (27%)
		IGc2	264..327	CDD:197706	19/74 (26%)
		I-set	344..430	CDD:254352	28/87 (32%)
		Ig	363..428	CDD:299845	22/66 (33%)
		FN3	611..703	CDD:238020	23/103 (22%)
		FN3	711..799	CDD:238020	20/115 (17%)
		FN3	806..897	CDD:238020	20/115 (17%)
		FN3	908..989	CDD:238020	20/94 (21%)
		FN3	1011..1097	CDD:238020	12/85 (14%)
		FN3	1109..1205	CDD:238020	13/39 (33%)
		Neogenin_C	1273..1521	CDD:284094
Robo4	XP_006510707.1	Ig	41..144	CDD:386229	28/102 (27%)
		Ig	152..236	CDD:386229	27/83 (33%)
		FN3	361..446	CDD:238020	27/105 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100