DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Fndc1

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_006523412.1	Gene:	Fndc1 / 68655	MGIID:	1915905	Length:	1833	Species:	Mus musculus

Alignment Length:	824	Identity:	191/824 - (23%)
Similarity:	313/824 - (37%)	Gaps:	201/824 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   792 SAEIRVKTFSSTPSE---PPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQV 853
            :|.:.|.|.:..|.:   .|.:|.| ::::..:.|.|:|| ::..:..:..|.|.|.  |....:
Mouse    21 AALLPVATSAGPPVDHPLKPRHVKL-LSTNMGLKVTWDPP-KDASSRPVEYYNIAYG--KSLKSL 81

  Fly   854 KSTPAN--------------IRYFELSNLDRNAEYQ--------------VKIAAMTVNGSGPFT 890
            ||...|              :.||.|...:.::...              :||....:.|.|||.
Mouse    82 KSIKVNAETHSFLIKDVEPGVVYFVLVTAENHSGVSRPVYRAESPPGGEWIKIDGFPIKGPGPFN 146

  Fly   891 EWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIK----IRNYVLGWGRGIPDE 951
            |         .:.|.:||.||:.:.:....:.:::.|..|:....|    .|.::||:|......
Mouse   147 E---------TVTEKEVPNKPLRMRVRASDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKM 202

  Fly   952 NTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTR----DEEPVDAPTPLEVPV 1012
            |.:.|...||.|.:|.|.|...|||||::.|.:|...|:|....|:    :|:.:|.|..:.|.|
Mouse   203 NYVPLTRDERSHEIKKLASESVYVVSLQSTNSQGQSQPVYRAALTKRKHAEEDELDVPEDISVRV 267

  Fly  1013 GLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITG-SNRYRYHNTTDLNCMINDLRPNT 1076
                  |||.|::|.|:|.::.|.:.|..:|.|||.|...| |.|:.|...::...:::.|.|:|
Mouse   268 ------MSSQSVLVAWVDPLVEKQKRVVASRQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDT 326

  Fly  1077 QYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITG 1141
            .|||||::.:|.|:..||.|:...|.::.|.|.|..:.|......|..|.|.|.....:.|::..
Mouse   327 VYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDALPESEGKVKE 391

  Fly  1142 YNIYYTTDTTKRDRDWSVEA--FAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSY- 1203
            |.:.|....    :.:..::  |:|..|..::..|:|...|.||::|...:|......:.:|:.
Mouse   392 YILSYAPAL----KPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNRRGPGPHSKAFIVAIP 452

  Fly  1204 TTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQ-----SSP------ 1257
            |||:.....:|:    |.|:.                          |||:     |||
Mouse   453 TTSSTEASAQPN----GRDSS--------------------------RKPEKLQQPSSPAPKVAA 487

  Fly  1258 --EHTKKSYQKNNVGVPKPPDLWIHHDQMELKNIDKGL--------HTVTPVCSDGASSSGALTL 1312
              |||..:                       ||:...|        ::|.|..:...|..|.|..
Mouse   488 SSEHTPSA-----------------------KNVKDALSDLNKIRTNSVVPGKTQLHSKMGELDP 529

  Fly  1313 PRSVVHSEYE---VETPVPGHVTNSLDKRSY-VPGYMTTSMNGTMERPQYP-RTQYSHQNRSHMT 1372
            ..:.|..|.|   :|.|....:.....|:.. ||   :.|.:|.:...:.| ||......|..:.
Mouse   530 QSTEVTGEEELDSLEDPRSSRLETLNQKQPLRVP---SRSGHGVLTPGRTPARTGLPVLPRKEVM 591

  Fly  1373 MEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGHP-LKSFSVP 1436
            ...|.|.....:|:....|.:..|.....|            |..|...|..:.|.| .|:.|.|
Mouse   592 DRRGPSLDPHLRPRVEPSASSAYHQLSSID------------NDSVDQNEYDQAGSPDPKAVSSP 644

  Fly  1437 GPP-----------PTGGAT-----------PVTKHTPAVTIRPQNQSPYKKPSFSAATP---NR 1476
            ..|           |:..|.           |.||.:.:......:.|..::.|.:||.|   :.
Mouse   645 SSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAQPRSHSL 709

  Fly  1477 LQGGGS---------VVHSTDE------IQRLAPSTSTEELNQE 1505
            ||||.|         .||::..      :....||..||...:|
Mouse   710 LQGGSSRPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845
		IG_like	257..340	CDD:214653
		IGc2	264..327	CDD:197706
		I-set	344..430	CDD:254352
		Ig	363..428	CDD:299845
		FN3	611..703	CDD:238020
		FN3	711..799	CDD:238020	2/6 (33%)
		FN3	806..897	CDD:238020	24/121 (20%)
		FN3	908..989	CDD:238020	25/84 (30%)
		FN3	1011..1097	CDD:238020	31/86 (36%)
		FN3	1109..1205	CDD:238020	20/98 (20%)
		Neogenin_C	1273..1521	CDD:284094	59/287 (21%)
Fndc1	XP_006523412.1	FN3	37..117	CDD:214495	17/83 (20%)
		FN3	155..238	CDD:214495	25/82 (30%)
		FN3	258..351	CDD:238020	35/98 (36%)
		FN3	359..449	CDD:238020	19/93 (20%)
		PHA03247	<636..1209	CDD:223021	27/118 (23%)
		FN3	1597..1688	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900